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The mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiation of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensory genital and cerebral stimuli integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation. To date, three 5-HT receptor subtypes 5-HT(1A), 5-HT(1B), and 5-HT(2C) have been postulated to mediate 5-HT's modulating activity on ejaculation. Dosage & Administration Adult (18 to 64 years of age): The recommended starting dose for all patients is 30 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. If the effect of 30 mg is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg. The maximum recommended dosing frequency is one dose every 24 hours. Interaction CNS active medicinal products: The use of Dapoxetine in combination with CNS active medicinal products has not been systematically evaluated in patients with premature ejaculation. Consequently, caution is advised if the concomitant administration of Dapoxetine and such medicinal products is required. PDE5 inhibitors: Tadalafil did not affect the pharmacokinetics of Dapoxetine. Sildenafil caused slight changes in Dapoxetine pharmacokinetics, which are not expected to be clinically significant. However, Dapoxetine should be prescribed with caution in patients who use PDE5 inhibitors due to possible reduced orthostatic tolerance. Tamsulosin: Concomitant administration of single or multiple doses of 30 mg or 60 mg Dapoxetine to patients receiving daily doses of Tamsulosin did not result in changes in the pharmacokinetics of Tamsulosin. However, Dapoxetine should be prescribed with caution in patients who use alpha adrenergic receptor antagonists due to possible reduced orthostatic tolerance. Warfarin: There are no data evaluating the effect of chronic use of Warfarin with Dapoxetine; therefore, caution is advised when Dapoxetine is used in patients taking Warfarin chronically. Ethanol: Concomitant use of alcohol and Dapoxetine could increase the chance or severity of adverse reactions such as dizziness, drowsiness, slow reflexes, or altered judgment. Combining alcohol with Dapoxetine may increase these alcohol-related effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Dapoxetine. Contraindications Patients with known hypersensitivity to Dapoxetine Hydrochloride. Patients with significant pathological cardiac conditions such as heart failure (NYHA class II-IV), conduction abnormalities (second or third degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease of significant valvular disease. Concomitant treatment with monoamine oxidase inhibitors (MAOIs), thioridazine. Similarly, MAOIs or thioridazine should not be administered within 7 days after Dapoxetine has been discontinued. Concomitant treatment with serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with these medicinal/herbal products. Side Effects Dizziness, Headache, Somnolence, Tremor, Blurred vision, Tinnitus, Sinus congestion, Nausea, Diarrhea, Abdominal pain, Dry mouth, Fatigue, Insomnia, Hypertension. Pregnancy & Lactation Dapoxetine is not indicated for use by women. It is not known either dapoxetine or its metabolites are excreted through human breast milk. Precautions & Warnings Patient with bleeding disorders, epilepsy, susceptibility to angle-closure glaucoma or raised intraocular pressure. Not intended for use in women. Known CYP2D6 poor metabolisers. Overdose Effects There were no unexpected adverse events in a clinical pharmacology study of Dapoxetine with daily doses up to 240 mg. In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. In cases #longlastingsexmedicine#bddrug24 #bestsexmedicineinbd#

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Tadalafil vs Sildenafil. Intimate vs Vigorex. Tadalafil এর কাজ কি। Sildenafil কিভাবে কাজ করে । সিলডেনাফিল এবং টাডালাফিলের পার্থক্য। Common Brand name of Sildenafil: Vigorex 50mg, Vigorex 100mg, Silagra 50mg, Silagra 100mg, Aggra 100mg, Niagra 50mg, Senegra 50mg Common Brand name of Sildenafi: Intimate 10mg, Intimate 5mg, Edysta 10mg, Edysta 5mg, Tab. Nirvana 10mg Penfil 10mg, Feel 10mg Timestamp 00:14 Tadalafil Vs Sildenafil 05:06 Erection This is Md Hirok Sheikh B.Pharm, M.Pharm Jahangirnagar University Founder of Clear Concept #sildenafil #health #clearconceptRdx Surge Male Enhancement Supplement

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How Long Is a Man Sexually Active in Old Age? Aging doesn’t have to mean the end of a fulfilling and active sexual life. In this video, we explore how long men can remain sexually active in old age, the factors that influence sexual health, and the changes that come with aging. Discover practical tips to maintain intimacy, manage common challenges like erectile dysfunction, and embrace a satisfying sex life at any stage of life. Whether it’s about physical health, emotional connection, or lifestyle choices, this video provides valuable insights to help men and their partners enjoy a thriving relationship. #SexualHealth #HealthyAging #Relationships #MenHealth #Intimacy #AgingGracefully #ActiveLifestyle #ErectileDysfunction #Wellness #SeniorHealth #HealthyRelationships #SexualWellbeing #MentalHealth #LifestyleTips

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The issue of sexual health continues to be one that the world is wrestling with. Interest in alternative treatment approaches for conditions like erectile dysfunction (ED) has increased against this backdrop. One such popular approach during the last few months has been ED gummies. These gummies are easy to use and discreet, as they are marketed as a natural way to solve ED problems with quick action and no need for invasive procedures or everyday prescription pills.

Dr. Oz Weighs In

A renowned cardiothoracic surgeon and television personality, Dr. Mehmet Oz, recently discussed ED gummies on his show highlighting their possible advantages and disadvantages. Dr.Oz stressed on understanding the contents in these gummies and how they help blood flow enhancement and sexual functionality.He however cautioned that despite many people seeing improvements in their symptoms of ED after using these gummies, it should not be relied upon alone on as a long term solution.

According to Dr. Oz, ED gummies can be used as an adjunct when looking for quick fixes but never replace professional medical advice or treatment care.A healthcare provider should be consulted in order to address the underlying causes of ED and explore comprehensive treatment options.Dr.Oz warned consumers of fake claims by manufacturers of ED GUMMIES reminding them there is no universal remedy to every sexual health issue.

Potential Benefits of ED Gummies

One benefit provided by ED gummies could be their ease of use and convenience.Unlike traditional medications for erectile dysfunction which might require a prescription or have potential side effects, over-the-counter edibles may contain natural substances such as L-arginine or Ginseng that can potentially improve blood circulation related matters including sex life.

There are also users who claim that absorption rates from eating these fruity gumdrops are faster than those from capsules or any other form of medication; hence why they have become quite popular among men desiring instant results.However, there are individuals who wish to keep their problems private and avoid hassle when it comes to dealing with ED, thus they choose gummy candies.

Potential Drawbacks of ED Gummies

However, these gummy-like foods for impotence do come with their cons as well. One such downside is the fact that there is no regulation in place for supplements made from natural substances.This lack of scientific data and clinical testing supporting some claims means that many people may not get to know how useful certain edibles are.

Another concern is that using these products over an extended period might have unknown long-term effects thereby raising safety concerns. Potential risks associated with these products should be taken into consideration by consumers especially while incorporating them into daily routines and medical consultations should be done before taking any action.

Expert Recommendations

ED gummies can provide a convenient approach to managing erectile dysfunction without invasive methods; however, caution and skepticism are necessary with them. In addition, Dr.Oz states that men who use them should also address other common contributors like hormonal imbalances, poor circulation or psychological factors.

To individuals who are considering using ED gummies, Dr. Oz suggests that it would be good to do a thorough investigation of the product’s ingredients and manufacturer reputation, as well as seeking customer reviews. Therefore, one must also see a healthcare provider who will advise on treatment options that suit their individual needs and health problems.

Conclusion

ED gummies have been intriguing for people who want different solutions to erectile dysfunction in general. Even though they can provide the ease of use and possible effectiveness, there is need to be careful before accepting them. Thus, it is important to consult with a doctor and develop an entire regime aimed at eradication of the root causes of ED for the purpose of maintaining desirable sexual health in long term.

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In this video, I go over three things that you should know prior to using a penis pump safely. Penis pumps and vacuum erection devices are simple things to use, but when used improperly or by people with underlying medication conditions, it can cause serious problems. If you are interested in checking out a penis pump that is fairly high quality: https://vaxaid.com?oid=12&affid=1156 FYI, I do get a small commission from the company for each purchase The three categories of problems include the following 1. Blood thinners or diseases that cause people to have a tendency to bleed 2. Improperly using the constriction ring applied at the base of the penis 3. Diseases that cause people to develop a priapism or erection for more than 4 hours. Disclaimer: This video is not intended to provide diagnosis, treatment or medical advice. Information obtained from this video should not be taken in lieu of your own medical provider's advice and treatment plan. Please consult directly with a physician or other healthcare professional regarding any diagnosis or treatment plan options. Content provided on this Youtube channel is for informational purposes only and should not be considered as a substitute for advice from a healthcare professional. The statements made about specific products throughout this video are not to diagnose , treat, cure or prevent disease As always, consult with your medical doctor if you have any questions specific to your medical situation.

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Zinc-Rich Foods: Cause and Effect: Zinc is a vital mineral for testosterone production, which plays a significant role in sexual development and function. A deficiency in zinc can lead to reduced testosterone levels, affecting libido and sperm quality. Copy the link below to your browser to open it http://book723.com/enlarge-your-penis/ ↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑↑ Copy the link into your browser to open it Benefits: Consuming zinc-rich foods can help maintain healthy testosterone levels, potentially leading to improved sexual performance and contributing to the health of the prostate and testes. How-to: Foods such as oysters, red meat, poultry, beans, nuts, and whole grains are excellent sources of zinc. Incorporating these into your diet can provide the necessary zinc for optimal sexual health. Essential Fatty Acids: Cause and Effect: Omega-3 and Omega-6 fatty acids are essential for maintaining healthy blood circulation, which is crucial for achieving and sustaining erections. These fats also have anti-inflammatory properties that can support overall health. Benefits: Adequate intake of essential fatty acids can lead to better blood flow to the penis, potentially resulting in stronger and more rigid erections. How-to: Include fatty fish like salmon and mackerel, as well as plant sources such as flaxseeds and walnuts, in your diet to ensure you're getting enough of these important fats. L-Arginine: Cause and Effect: L-arginine is an amino acid that serves as a precursor to nitric oxide, which is responsible for dilating blood vessels and improving blood flow. Better blood flow can lead to stronger erections and may contribute to the appearance of a larger penis. Benefits: Supplementing with L-arginine may improve erectile function and enhance sexual performance. How-to: Foods like lean meats, fish, dairy products, and certain nuts and seeds are rich in L-arginine. Adding these to your diet can help increase the body's production of nitric oxide. Precautions and Considerations: While these dietary approaches can support sexual health, they should not be seen as a guaranteed method for penis enlargement. Results can vary greatly among individuals. It's important to maintain a balanced diet and not over-rely on any single nutrient. A varied diet is essential for overall health. Always consult with a healthcare provider or a nutritionist before making significant dietary changes, especially if you have pre-existing health conditions. Conclusion: A diet rich in zinc, essential fatty acids, and L-arginine can support your sexual health and potentially contribute to improved penile function. By understanding the impact of these nutrients on the body, you can make informed choices to enhance your sexual well-being.