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Welcome to The Peptide Podcast. Today we’re going to talk about something that almost everyone on a GLP-1 journey hits eventually, the weight loss plateau. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. It starts like this: you begin a GLP-1 like semaglutide or tirzepatide, and for the first few weeks or months, the weight seems to fall off. You’re eating less, not obsessing over food, and for the first time in a long time, it feels… easy. Then one day, the scale just stops moving. You’re not doing anything different. You’re still taking the meds. Still trying to eat well. Maybe you’re walking more or lifting weights. But suddenly, nothing’s happening—and the frustration kicks in. Sound familiar? Let’s talk about what’s really going on. 1. What Causes the Plateau? First of all, if you’re in this place right now: you didn’t mess up. GLP-1s are incredibly effective at reducing appetite and creating an initial calorie deficit, which is why people lose weight so quickly in the beginning. But your body isn’t just going to let that continue unchecked. It adapts. This is called adaptive thermogenesis—a fancy way of saying your body becomes more efficient. You start burning fewer calories at rest than you did before. Your resting metabolic rate actually drops beyond what you'd expect just from losing weight alone. It’s a survival mechanism. So what worked at the beginning—eating less and moving a bit more—might no longer be enough to keep the scale moving. This is totally normal. 2. Metabolism & Muscle: Why Strength Training Matters Now More Than Ever So now that we know why the plateau happens, let’s talk about things we can do to help us get over it. Something that often gets overlooked but is absolutely critical—especially if you’re on a GLP-1 or in any kind of calorie deficit. Resistance training is not optional. It’s non-negotiable. Here’s why. When you’re losing weight—whether it’s from a medication like semaglutide or just eating in a calorie deficit—your body isn’t just pulling energy from fat. If you’re not careful, it’s also going to break down lean muscle tissue. And the more muscle you lose, the slower your metabolism gets. Why? Because muscle is metabolically active tissue. It burns calories even when you’re doing absolutely nothing. So if you’re not actively sending a signal to your body to keep that muscle, it’ll start to let it go. That’s where resistance training comes in. When you lift weights or do bodyweight exercises—think squats, push-ups, resistance bands, even heavy housework—you’re telling your body: “Hey, I need this muscle. Don’t burn it for fuel.” This is especially important for those on GLP-1s because these meds reduce appetite so significantly that you might not be eating enough protein—or enough calories in general—to maintain muscle without that extra stimulus. So if you’ve hit a plateau or want to prevent one, ask yourself: Am I strength training at least two to three times a week? Am I prioritizing movements that challenge large muscle groups—like legs, glutes, chest, and back? Am I fueling my workouts with enough protein? And let me be really clear, you don’t have to become a gym rat. You don’t have to lift crazy heavy weights. But you do have to move your muscles in a meaningful, consistent way. Protecting your lean mass is one of the best ways to keep your metabolism humming—not just during your weight loss journey, but after it too. Because this isn’t about just losing weight—it’s about building a strong, metabolically healthy body that can maintain that weight loss for life. 3. Mindset Check: The Plateau Is Not a Failure Now, let’s get into the mental side of this journey—because it’s just as important as nutrition, movement, and medication. One of the biggest challenges people face—especially when progress slows—is the mental roller coaster that comes with watching the scale. And I’ll be honest: weighing yourself every single day is not ideal. Here’s why. Your body weight naturally fluctuates. Daily. And those fluctuations have nothing to do with your actual fat loss or long-term progress. Instead, the number on the scale is influenced by things like: Hydration status – If you’re slightly dehydrated, the scale may dip. But if you drank a ton of water the day before or had more salty food, it may go up due to water retention. Glycogen stores – When you eat carbs, your body stores them in your muscles and liver as glycogen, and for every gram of glycogen, your body stores about 3–4 grams of water. So a...

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Discover the truth behind the long-term safety of the Keto diet in our latest video, "Is Long-Term Keto Diet Safe?" We delve into the science of ketosis, exploring its effects on metabolism, cardiovascular health, and overall well-being. Are the benefits worth the risks? Join us as we discuss expert opinions, potential side effects, and tips for maintaining a balanced approach to Keto. Whether you're a long-time follower or just curious about this high-fat, low-carb lifestyle, this video provides valuable insights you won't want to miss. Like and share if you find the information helpful! Learn More: https://healthydiethappylife.com/is-ketosis-safe-for-long-term-health/

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00:00 - Unlocking Weight Loss: The GLP-1 Diet and Exercise Guide 04:13 - Managing GLP-1 Medication Side Effects: Nutrition & Exercise Tips for Safe Weight Loss 1. Unlocking Weight Loss: The GLP-1 Diet and Exercise Guide Discover how to maximize weight loss with GLP-1 medications through personalized diet and exercise strategies. In this video, we explore expert insights on integrating GLP-1 therapy with nutrition and physical activity for long-term success. Learn about the importance of monitoring weight, managing nutrient intake, and the role of physical activity in achieving your weight loss goals. Don't miss tips on avoiding common side effects and maintaining muscle mass while on GLP-1 medications. 2. Managing GLP-1 Medication Side Effects: Nutrition & Exercise Tips for Safe Weight Loss Discover essential nutrition and physical activity guidance for patients using GLP-1 receptor agonists like Wegovy, Ozempic, and Mounjaro. This video covers how tailored diet and exercise can help mitigate side effects, preserve muscle mass, and prevent nutritional deficiencies during GLP-1 weight-loss treatment. Learn about recommended protein intake, calorie targets, hydration, and micronutrient monitoring to support your health. We also explain the importance of resistance training and aerobic exercise to maintain lean body mass and improve overall outcomes. Whether you're starting GLP-1 therapy or managing side effects, this video provides practical clinical strategies based on the latest research from Harvard T.H. Chan School of Public Health and JAMA Internal Medicine. Keywords: GLP-1 side effects, GLP-1 nutrition, GLP-1 exercise, Wegovy diet, Ozempic muscle loss, weight loss medication guidance, preserving lean mass, resistance training for weight loss, managing GLP-1 side effects, nutritional deficiencies GLP-1

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Wondering how much weight you can expect to lose on GLP-1 medications like semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound)? Dr. Lindsay Ogle from breaks down the average weight loss results seen in clinical studies. Dr. Ogle also discusses why weight loss with GLP-1s is gradual, how results vary for each person, and what you can realistically expect on your weight loss journey. In this video: -Average weight loss with semaglutide (Ozempic, Wegovy) -Average weight loss with tirzepatide (Mounjaro, Zepbound) -How long it takes to see results on GLP-1 medications -Why individual results may vary -Realistic expectations for GLP-1 weight loss treatment For more expert tips on weight loss medications, healthy living, and GLP-1 therapy, subscribe to our channel and check the links in the description. Instagram: instagram.com/quick.md Book Now: https://booking.quick.md/services?state=AL #GLP1 #Semaglutide #Tirzepatide #Ozempic #Wegovy #Mounjaro #Zepbound #WeightLoss #GLP1Results #WeightLossJourney #QuickMD #ObesityMedicine #HealthTips

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