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Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity. In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. *Guest information* Anurag Singh, MD, PhD Chief Medical Officer at Timeline *Thank you to our sponsor* Timeline: https://tinyurl.com/4npjcvjf Mitopure: https://tinyurl.com/ypfjws2e Research from Timeline: https://tinyurl.com/53p6yjc9 [email protected] *Timeline Discount for New Frontiers Listeners* Timeline is offering Dr. Fitzgerald’s readers a 10% discount on Timeline products. Head on over to https://tinyurl.com/ypfjws2e and use the code KARA10 at the checkout. *Show Notes* Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity: https://tinyurl.com/y3c2ypkw Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55= Years Old: A Randomized Triple-Masked Controlled Clinical Trial - https://https://tinyurl.com/bdzfccr8 Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults - https://tinyurl.com/2p9pjpxc Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance - https://tinyurl.com/2jkhmu9w Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis - https://tinyurl.com/mvrjxxsm Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial - https://tinyurl.com/fscfdd85 Study: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans - https://tinyurl.com/mr2hd4ms Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population - https://tinyurl.com/e6npdvyp Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials - https://tinyurl.com/2m2nzd56 Preclinical trial: Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance (ENDURO) - https://tinyurl.com/nhkw2pvc Study: The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome - PubMed (nih.gov) - https://tinyurl.com/mrkk33e5 Study: Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice | PLOS Biology - https://tinyurl.com/3s38vtau Study: Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals - PubMed (nih.gov) - https://tinyurl.com/wdzk3tx7 *DrKF Resources* FxMed Podcast: Beyond Mitochondrial Health: Can Urolithin A Slow Down Aging? - https://tinyurl.com/svzahswu DrKF Blog: Beyond Beauty: Targeting Skin Longevity with Urolithin A - https://tinyurl.com/5n6zfu9s DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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Welcome to the Downsizing Diva LIVE! In this informative episode, we’re diving into everything you the typical day on a GLP-1 weight loss journey, knee pain exercise, fitness tips, and even reviewing the latest in dating shows. If you’re on a path to shed pounds, get fit, and embrace a healthier lifestyle, this live session is packed with insights and inspiration. #mounjaro #glp1 #knee pain #knee pain exercises #weightlossjourney #zepbound Whether you’re taking GLP-1 medications like Mounjaro, Zepbound, Ozempic, or Wegovy, just starting your weight loss journey, this video is for you. I’ll share my personal experiences, practical fitness tips, and strategies to keep you motivated. Plus, we’re having some fun with a review of popular dating show—because self-love and relationships are all part of the journey! If you’re a woman or man focused on losing weight, navigating the challenges of GLP-1 medications, or seeking actionable advice for fitness and wellness, don’t miss this interactive session. Let’s connect, support one another, and build a community of health and confidence! Subscribe to my channel: youtube.com/@DownsizingDiva?sub_confirmation=1 Email: downsizingdiva8‪@gmail.com‬ A way to support my channel (Cash App): $downsizingdiva8 Amazon Affiliate Links to help you on your Weight Loss Journey: LifePro 3D Vibration Plate Exercise Machine: https://a.co/d/7HQmLH8 Niceday Steppers for Exercise: https://a.co/d/5s8SCGa nbpure MagO7 - Natural Colon Cleanse & Detox: https://a.co/d/3U3mA4L Pure Encapsulations Magnesium (Glycinate): https://a.co/d/3HJsGZR TULA Skin Care 24-7 Hydrating Day & Night Cream: https://a.co/d/5wIDtio TULA Skin Care Clarifying Tonic Alcohol-Free Daily Toner: https://a.co/d/c8LQqSd *Get a free LMNT Sample Pack using my referral link with your first purchase so you can try out more flavors. Thank you & Stay Hydrated! LMNT Electrolyte Link: https://elementallabs.refr.cc/default/u/downsizingdiva Gruns Gummy Vitamins Link: https://www.gruns.co/pages/vip?snowball=downsizingdiva38294If you would like to donate to my channel: Watch My Incredible Weight Loss Journey: https://youtu.be/hfOiLsLg5Vg?si=4_Q6OgthmfWMcFcA Watch My Mounjaro 6 Month Review: https://youtu.be/Or4E6twIWEk?si=t--npUlhf0uHacIo

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When it comes to weight loss, many individuals are constantly searching for new solutions to help them reach their goals. One option that has gained significant attention in recent years is the use of semaglutide, a medication originally developed for managing type 2 diabetes. However, as studies have shown promising results in terms of weight loss, many people are now wondering: How long does semaglutide take to work for noticeable weight loss?

Semaglutide: An Overview

Semaglutide is a medication that belongs to a class of drugs known as GLP-1 receptor agonists. These drugs work by mimicking the effects of glucagon-like peptide-1 (GLP-1), a hormone that plays a role in regulating blood sugar levels and food intake. By increasing the levels of GLP-1 in the body, semaglutide can help reduce appetite, slow down stomach emptying, and promote a feeling of fullness, ultimately leading to weight loss in some individuals.

How Does Semaglutide Work for Weight Loss?

When it comes to weight loss, semaglutide is thought to work through a combination of mechanisms. First and foremost, the medication helps regulate blood sugar levels by stimulating the release of insulin and inhibiting the secretion of glucagon, a hormone that raises blood sugar levels. By keeping blood sugar levels stable, semaglutide can help reduce cravings and prevent overeating, leading to a decrease in calorie intake and subsequent weight loss.

Factors Affecting the Time to See Results

While semaglutide has shown promising results in clinical trials, the time it takes to see noticeable weight loss can vary from person to person. Several factors can influence how quickly the medication works, including the individual’s starting weight, diet, exercise habits, and overall health. In general, many people may start to see some changes within the first few weeks of starting semaglutide, but significant weight loss results may take several months to manifest.





Potential Side Effects of Semaglutide

Like any medication, semaglutide comes with a risk of side effects, some of which may impact its effectiveness for weight loss. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, which can make it challenging for some individuals to adhere to the medication long-term. It’s essential to discuss the potential side effects and benefits of semaglutide with your healthcare provider to determine if it’s the right option for you.

Final Thoughts on Semaglutide for Weight Loss

While semaglutide shows promise as a treatment for weight loss, it’s crucial to approach it as part of a comprehensive weight management plan that includes a healthy diet, regular exercise, and behavioral changes. By working closely with your healthcare provider and making sustainable lifestyle modifications, you can maximize the benefits of semaglutide and achieve long-lasting weight loss results. Remember, individual experiences may vary, so it’s essential to be patient and consistent in your efforts to see the best outcomes.

Summary and FAQ

In summary, semaglutide is a medication that can help promote weight loss by regulating blood sugar levels, reducing appetite, and promoting feelings of fullness. While the time it takes to see noticeable weight loss results may vary, many individuals may start to see changes within a few weeks of starting the medication. However, significant weight loss may take several months to achieve, depending on various factors such as diet, exercise habits, and overall health.

As for common side effects, semaglutide may cause nausea, vomiting, diarrhea, and constipation, which can impact its effectiveness for weight loss in some individuals. It’s essential to discuss the potential risks and benefits of semaglutide with your healthcare provider to determine if it’s the right option for you. By approaching semaglutide as part of a comprehensive weight management plan that includes healthy lifestyle changes, you can maximize its benefits and achieve successful weight loss in the long run.

Ultimately, the key to successful weight loss with semaglutide lies in consistency, patience, and a holistic approach to health and wellness. By staying committed to your goals and working closely with your healthcare provider, you can harness the potential of semaglutide to achieve lasting changes in your weight and overall well-being. Remember, everyone’s journey is unique, so it’s essential to focus on your progress and celebrate the small victories along the way towards a healthier, happier you.

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Are you considering using semaglutide for weight loss and looking for a detailed dosage chart to guide you through the process? You’ve come to the right place. In this article, we will discuss everything you need to know about semaglutide dosage for weight loss, including the recommended dosages, how to take it, and important considerations to keep in mind. Understanding the proper dosage of semaglutide is crucial for achieving the best results while minimizing potential side effects. Let’s dive in and explore the world of semaglutide weight loss dosage together.

Recommended Dosages

Semaglutide is a prescription medication that is used to help individuals with obesity and overweight achieve weight loss. The recommended dosage of semaglutide for weight loss is to start with a low dose and gradually increase it over time. The typical starting dose is 0.25 mg once a week, which can be increased to 0.5 mg and eventually 1.0 mg depending on individual response and tolerability.

It is important to follow your healthcare provider’s instructions regarding the dosage of semaglutide and not make any changes without consulting them first. Your healthcare provider will monitor your progress and adjust the dosage as needed to ensure optimal results.Starting A Weight Loss Medication Mounjaro Ozempic Weightloss

Additionally, it is crucial to take semaglutide exactly as prescribed by your healthcare provider. Do not take more or less of the medication than recommended, and do not skip any doses. Consistency is key when it comes to achieving successful weight loss with semaglutide.

How to Take Semaglutide

Semaglutide is typically injected subcutaneously (under the skin) once a week. It is important to choose a consistent day and time each week to take your semaglutide dose to help you establish a routine and stay on track with your weight loss goals.





Before injecting semaglutide, make sure to properly clean the injection site with an alcohol swab and allow it to dry. Follow the instructions provided with your medication for how to prepare and administer the injection. If you have any questions or concerns about how to take semaglutide, do not hesitate to ask your healthcare provider or pharmacist for guidance.

Remember to rotate injection sites to prevent skin irritation or lumps from forming. Common injection sites for semaglutide include the abdomen, thigh, or upper arm. Be sure to keep track of the injection sites you use and avoid injecting semaglutide into areas of the skin that are bruised, red, or hard.

Important Considerations

Before starting semaglutide for weight loss, it is essential to discuss with your healthcare provider any medical conditions you have, medications you are taking, and any allergies you may have. Certain medical conditions or medications may interact with semaglutide or affect its effectiveness, so it is important to be transparent with your healthcare provider about your health history.

While taking semaglutide, monitor your blood sugar levels regularly if you have diabetes, as the medication may affect your blood sugar levels. If you experience symptoms of low blood sugar (hypoglycemia) such as shakiness, sweating, or confusion, be sure to have a fast-acting source of sugar on hand to raise your blood sugar level quickly.

It is also important to stay hydrated and maintain a healthy diet and exercise routine while taking semaglutide for weight loss. Semaglutide is not a magic solution for weight loss and should be used in conjunction with lifestyle changes to achieve long-lasting results.

Summary and FAQ

In conclusion, semaglutide can be an effective tool for weight loss when used correctly and under the guidance of a healthcare provider. By following the recommended dosages, understanding how to take semaglutide properly, and considering important factors, you can maximize the benefits of this medication and achieve your weight loss goals. If you have any additional questions or concerns about semaglutide weight loss dosage, consult with your healthcare provider for personalized guidance.

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