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Gerianne DiPiano and her co-host Dr. Katherine Sherif discuss GLP-1 medications. These products have become very popular in treating diabetes and weight loss, but how much do we know about them? What are the benefits for women and what are some risk factors to consider? Learn what you should ask your doctor to find out if these medications are right for you.

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Josh Hillis, RKC2 interviews Amanda Sullivan RKC, Kelly Cassidy RKC, and Mary Ann Lubas RKC about why they use kettlebells with their fat loss clients, and what kettlebells have done for their own fitness and how kettlebell training has helped them get lean and tight in all the right places.

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Dr. Gil Blander and Ashley Reaver dive into the science behind GLP-1 agonists, a class of drugs originally developed for type 2 diabetes but now widely used for weight management and longevity. They explore how these medications work, their effects on appetite, metabolism, and inflammation, and why they might be a game-changer for cardiovascular health, brain function, and fertility. While promising, they emphasize the importance of long-term research and consulting with medical professionals before considering these treatments. The conversation shifts to the role of wearables in health tracking. Gil shares insights on devices like the Apple Watch, Oura Ring, and Whoop, highlighting their capabilities in tracking sleep, fitness, illness detection, and fall prevention—especially for older adults. They break down how different wearables cater to specific needs and the future of personalized health monitoring. As the science of longevity evolves, Gil and Ashley stress the importance of staying informed, making data-driven decisions, and using technology wisely. Whether through cutting-edge pharmaceuticals or smart wearables, optimizing health is now more accessible than ever. Host-at-a-Glance 💡 Name: Gil Blander  💡What he does: Founder and CSO 💡Company: InsideTracker 💡Noteworthy: Expert in longevity, nutrition, and personalized health optimization 💡 Where to find them: LinkedIn Host-at-a-Glance 💡 Name: Ashley Reaver  💡What she does: Lead Nutrition Scientist 💡Company: InsideTracker 💡Noteworthy: Specializes in metabolism, nutrition, and biomarker-based health strategies 💡 Where to find them: LinkedIn  Episode highlights: [00:00:00] Introduction  [00:02:02] Understanding GLP-1 Hormones [00:04:26] GLP-1 Receptor Agonists: Mechanism and Benefits [00:06:50] Impact of GLP-1 on Weight and Health [00:21:16] Side Effects and Considerations of GLP-1 Agonists [00:26:31] The Future of GLP-1 Agonists [00:34:54] Exploring Wearables for Health [00:36:08] Choosing the Right Wearable [00:40:29] Wearables for Detecting Illness and Falls [00:47:12] Conclusion and Final Thoughts Key Insights GLP-1 Agonists: A Breakthrough for Weight and Metabolic Health GLP-1 agonists, originally developed for type 2 diabetes, have become a game-changer for weight loss, appetite control, and longevity. These drugs mimic natural gut hormones that regulate hunger and insulin secretion, helping people feel full longer and stabilizing blood sugar levels. Studies show that GLP-1 agonists can reduce body weight by up to 25%, a level comparable to bariatric surgery. Beyond weight management, these drugs may lower inflammation, improve cardiovascular health, and even reduce the risk of certain cancers. However, long-term use is likely necessary, as stopping the medication often leads to weight regain. Gil and Ashley emphasize the importance of medical supervision and highlight ongoing research into how GLP-1 impacts cognitive function and fertility. Long-Term Use of GLP-1 Agonists: Training the Body for Better Habits Many wonder if GLP-1 medications are a short-term fix or a lifelong commitment. While the drugs suppress appetite, weight regain is common after stopping treatment. Gil suggests using this period as a training phase—learning to prioritize whole foods, avoid processed meals, and build sustainable habits. He also highlights the importance of exercise, especially strength training, as GLP-1 users risk losing muscle mass along with fat. Regular blood tests and nutrient monitoring are essential, as some users may experience vitamin deficiencies. The hosts caution against taking GLP-1 agonists solely for cosmetic weight loss and emphasize that obesity is a chronic, progressive condition requiring long-term management. This insight reinforces the idea that successful weight loss isn’t just about medication—it’s about lifestyle changes and long-term commitment. Wearables: The Future of Personalized Health Tracking Wearables are reshaping how individuals monitor their health from fitness to disease prevention. Gil and Ashley break down Apple Watch, Oura Ring, and Whoop, each catering to different needs. Apple Watch excels at fall detection and emergency response, making it ideal for older adults. Oura Ring provides early illness detection through temperature and heart rate variability tracking. Whoop is favored by athletes for its detailed recovery insights and sleep monitoring. Wearables aren’t just for data collection—they drive behavior change, encouraging users to improve sleep, exercise, and stress management. With AI-driven health coaching on the rise, the hosts predict that wearables will play a central role in proactive healthcare and longevity strategies. Longevity by Design is produced by InsideTracker, your data-driven wellness guide for optimizing your healthspan. For a limited time, visit https://hubs.li/Q021Z4gp0 for 20% off any InsideTracker plan.

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My 6-Month Compounded Tirzepatide GLP-1 Journey REVEALED! Six months ago, I added compounded Tirzepatide (a GLP-1 medication) to my weight loss journey. Today I'm sharing my week-by-week weight loss, the struggles, any side effects, and the TRUTH about my results – including my total weight and inches lost! If you're curious about GLP-1s or just looking for a real-life weight loss experience, this video is for you! Join me, as I share the good, the bad, and the truly transformative. Starting Weight (11/22/23): 196.9 lbs Last Week's Weight (Week 24): 161.4 lbs Current Weight (Week 26 - 05/23/24): 157.8 lbs Total Weight Loss: 39.1 lbs! ➡️ If you're on the fence about taking a GLP-1, let me know your questions in the comments! 👍 If you found this video helpful, please give it a thumbs up! 🔔 Don't forget to LIKE, SUBSCRIBE, and hit the BELL for more updates on my health journey! https://www.youtube.com/@perfectlypamela 📧 Email me at: [email protected] 💜💜💜Perfectly Pamela💜💜💜 Chapters Titles: 0:00 - Intro: My 6-Month Tirzepatide Journey 0:58 - Starting Point: Stats & First Dose 2:29 - First Injection: Nerves & Initial Reaction 4:25 - Week 1: Thanksgiving & 4lb Loss! 5:03 - Week 2: Feeling Like a Pro & Coffee Aversion 6:17 - Week 3: First Side Effects & Travel 7:27 - Week 4: Managing Expectations & Headaches 9:05 - Week 5: A Small Gain & Food Noise Returns 9:34 - Week 6: Titrating to 5mg - Too Intense! 10:43 - Week 7: Adjusting Down to 3.75mg 11:30 - Week 8: Back to 2.5mg & The Constipation Battle! 12:30 - Week 9: Up to 3.75mg & Discovering MagO7 (20lbs Lost!) 13:37 - Week 10: Titrating to 4.15mg & A Plateau Week 14:14 - Week 11: Success & Appetite Suppression on 4.15mg 14:49 - Week 12: Still on 4.15mg (25lbs Down!) 16:02 - Week 13: Switching to Hallandale Compound (Pure Tirzepatide) 16:53 - Week 14: Injection Site Sensation & Food Noise Increase 18:03 - Week 15: Back to 5mg - Success This Time! 19:12 - Week 16: 4 Months In - Almost 30lbs! 20:01 - Week 17: Hair/Nail Changes & Protein Focus (30lbs Down!) 21:27 - Week 18: Protein Snacks & Another Plateau 22:52 - Week 19: Fatigue, Overwork & Calorie Deficit 24:12 - Week 20: Bumping Up Calories for Energy 24:34 - Week 21: Calorie Increase & Expected Plateau 25:17 - Week 22: Mental Clarity & Reduced Food Noise! 27:30 - Week 23: Food Noise Returns - Time to Titrate? 28:27 - Week 24: Gradual Titration to 5.95mg - Success! 30:05 - Week 25: Hitting the 150s! (Protein & Calorie Sweet Spot) 33:05 - Week 26: Final Week - Almost 40lbs! 36:03 - Life-Changing Non-Scale Victories (NSVs) 37:04 - My Honest Advice & Encouragement 38:17 - The Measurement Reveal! (Total Inches Lost) 39:02 - Beyond the Scale: What Truly Matters 40:26 - Outro & Thank You! Disclaimer: I am not a medical professional. This video documents my personal weight loss journey and experiences. Please consult with your doctor before making any decisions about your health or treatment. #Tirzepatide #CompoundedTirzepatide #GLP1 #WeightLossJourney #WeightLossTransformation #6MonthUpdate #PerfectlyPamela #HealthJourney #WeightLossResults