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Pharmacology of GLP-1 Receptor Agonists and DPP-4 Inhibitors (Antidiabetic Drugs) [HINDI] by Dr. Shikha Parmar Diabetes mellitus is a disorder in which blood sugar (glucose) levels are abnormally high because the body does not produce enough insulin to meet its needs. Type 1 Diabetes Mellitus In type 1 diabetes (formerly called insulin-dependent diabetes or juvenile-onset diabetes), the body's immune system attacks the insulin-producing cells of the pancreas, and more than 90% of them are permanently destroyed. The pancreas, therefore, produces little or no insulin. Only about 5 to 10% of all people with diabetes have type 1 disease. Most people who have type 1 diabetes develop the disease before age 30, although it can develop later in life. Type 2 Diabetes Mellitus In type 2 diabetes (formerly called non– insulin-dependent diabetes or adult-onset diabetes), the pancreas often continues to produce insulin, sometimes even at higher-than-normal levels, especially early in the disease. However, the body develops resistance to the effects of insulin, so there is not enough insulin to meet the body’s needs. As type 2 diabetes progresses, the insulin-producing ability of the pancreas decreases. Complications of diabetes (1) Brain, causing a stroke (2) Eyes (diabetic retinopathy), causing blindness (3) Heart, causing a heart attack (4) Kidneys (diabetic nephropathy), causing chronic kidney disease (5) Nerves (diabetic neuropathy), causing a decreased sensation in feet Description Source: Wikipedia
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New type 2 diabetes and weight-loss drugs like Wegovy and Ozempic are transforming health care by helping users reduce blood sugar and lose significant weight, with potential revenue projected in the hundreds of billions. With high costs and limited insurance coverage, who will have access to these GLP-1 drugs? In this video, we’ll dive into the science, explore the hurdles relating to these novel drugs.
▶️ Watch our other videos: https://youtu.be/ycJ9stRpZQ4?feature=shared
Key Sections
0:20 - Ozempic & Wegovy becoming billion dollar products
1:28 - How do GLP1s actually Work?
3:16 - The different types of these novel drugs: GLP-1 Agonists
4:05 - GLP-1 & GIP (Tirzepatide)
4:55 - The side effects of these drugs
5:07 - The cost concern
5:57 - The rise of non-approved alternatives (DIY PEPTIDES)
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📚 This video serves as an excerpt from the pharmaceutical industry Learning Primer, meticulously curated by the digital e-learning content provider, Primerli https://www.primerli.com/. The full module, comprising 10 bite-sized videos and quick quizzes, is tailored to empower professionals to grasp the industry intricacies in under an hour.
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