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(https://isappscience.org/wp-content/uploads/2025/07/Greiner-cover.png) This episode features Dr. Thomas Greiner PhD from the University of Gothenburg (Sweden), speaking about the various functions of GLP-1 in the gut, and the role of gut microbes in GLP-1 production, with ultimate effects on host health. He noted that GLP-1 is produced by enteroendocrine cells called L-cells, both in the small intestine and the colon. These cells respond to nutrients and microbially-produced short-chain fatty acids, but responses differ between the small intestine and colon, leading Dr. Greiner to investigate the different functions of GLP-1 at these two sites. Using germ-free mice and other models, Dr. Greiner has developed a hypothesis that the function of GLP-1 in the small intestine is to improve insulin secretion postprandially, whereas the functions of GLP-1 in the colon are to allow for increased energy intake (in a situation of energy deficiency), dampen inflammation, and protect local tissues. He and his colleagues are taking two different approaches in aiming to improve metabolic health in humans: finding inhibitors of bacterial enzymes to decrease production of a harmful molecule produced by bacteria; and a probiotic approach of administering butyrate-producing bacteria. With the latter approach, the sensitivity of the bacteria to oxygen is a problem to overcome, but their group has evolved a bacterial strain to tolerate some oxygen, with the idea of testing it as a probiotic. Episode abbreviations and links: • Paper exploring the role of the gut microbiota in GLP-1 signaling: GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota (https://www.sciencedirect.com/science/article/pii/S2212877824000553?via%3Dihub) • Study on the functions of GLP-1 in the colon: Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(13)00365-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS193131281300365X%3Fshowall%3Dtrue) • Bäckhed Lab Instagram account: @backhed_lab (https://www.instagram.com/backhed_lab?igsh=MWdpdmlndDAxOWFjag==) About Dr. Thomas Greiner PhD: Thomas Greiner is a medical scientist at the Wallenberg Laboratory, University of Gothenburg, with over 15 years of experience in functional genetics and metabolic research. His work focuses on the intricate interplay between gut microbiota, intestinal hormones such as GLP-1, and host metabolism. He has explored how microbial and hormonal signals influence energy balance, intestinal function, and the development of metabolic diseases. His research primarily uses molecular approaches in mouse models to investigate the role of microbial signals in metabolic disease and to uncover new functions of gut hormones in regulating intestinal physiology. Sign up (https://isappscience.org/for-scientists/news/isapp-newsletters/) for our monthly newsletter Follow us (https://isappscience.org/contact/)  on LinkedIn, Bluesky, X, Facebook, Instagram, Threads The post Unraveling the functions of GLP-1 in the gut, with Dr. Thomas Greiner PhD (https://isappscience.org/episode-65-unraveling-the-functions-of-glp-1-in-the-gut/) appeared first on International Scientific Association for Probiotics and Prebiotics (ISAPP) (https://isappscience.org) .

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Join me on my weight loss journey with Mounjaro! In this video, I'll share what I ate to lose weight, including delicious meals like turkey chili and high-protein snacks. Follow along for tips on successful weight loss with Mounjaro and GLP1 medication. #mounjaro #zepbound #weightlossdiet *Don't forget to: 👍 Like this video if you found it helpful 💬 Comment with your thoughts or questions 🔔 Subscribe for more informative weight loss videos! *Get a free LMNT Sample Pack using my referral link with your first purchase so you can try out more flavors. Thank you & Stay Hydrated! LMNT Electrolyte Link: https://elementallabs.refr.cc/default/u/downsizingdiva Gruns Gummy Vitamins Link: https://www.gruns.co/pages/vip?snowball=downsizingdiva38294 If you would like to donate to my channel: Cash App: $downsizingdiva8 Watch My Incredible Weight Loss Journey: https://youtu.be/hfOiLsLg5Vg?si=4_Q6OgthmfWMcFcA Watch My Mounjaro 6 Month Review: https://youtu.be/Or4E6twIWEk?si=t--npUlhf0uHacIo

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Me & Yoga – A journey back to yourself. Here, I share gentle yoga exercises, simple meditations and ways to slow down amidst a busy life. Whether you are just starting out or looking for a deeper connection with your body and soul, “Me & Yoga” is always a place for you to stop, breathe and feel yourself. No need to be perfect – just be with your partner.

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Semaglutide is a medication that has gained attention for its potential to help with weight loss in individuals struggling with obesity. It works by mimicking the effects of a hormone that helps to regulate blood sugar levels and appetite. When used in higher doses than those typically prescribed for diabetes, semaglutide has been shown to significantly aid in weight loss for individuals with a BMI of 30 or higher. However, proper dosing of semaglutide is crucial to ensure both its effectiveness and safety.

Understanding Semaglutide Dosage

When it comes to using semaglutide for weight loss, the dosage is higher than what is typically used for diabetes management. The recommended dose for weight management is 2.4 mg once a week, administered via subcutaneous injection. This dosage has been found to be effective in helping individuals lose weight when combined with a reduced-calorie diet and increased physical activity.

It is important to follow the dosing instructions provided by your healthcare provider closely. Taking more than the recommended dose of semaglutide does not lead to faster weight loss and can increase the risk of side effects. It is also important to monitor your progress regularly and communicate with your healthcare provider about any concerns or changes in your weight loss journey.

For some individuals, a lower starting dose of semaglutide may be recommended to minimize potential side effects. In these cases, the dose may be gradually increased over time as tolerated. Your healthcare provider will determine the most appropriate dosing regimen for your specific needs based on factors such as your weight loss goals, medical history, and overall health.

Potential Side Effects of Semaglutide

As with any medication, semaglutide can cause side effects, especially when taken at higher doses for weight loss. Common side effects of semaglutide may include nausea, vomiting, diarrhea, constipation, and abdominal pain. These side effects are usually mild to moderate in severity and tend to improve over time as your body adjusts to the medication.





In some cases, semaglutide may also lead to more serious side effects such as pancreatitis or gallbladder problems. It is important to seek medical attention if you experience symptoms such as severe abdominal pain, persistent nausea or vomiting, or significant changes in your health while taking semaglutide.

Your healthcare provider will provide guidance on managing potential side effects and monitoring your health while taking semaglutide for weight loss. It is important to report any new or worsening symptoms to your healthcare provider promptly to ensure your safety and well-being during your weight loss journey.

Long-Term Benefits of Semaglutide for Weight Loss

While the primary goal of using semaglutide for weight loss is to achieve a healthier weight and reduce the risk of obesity-related complications, there are additional long-term benefits to consider. Losing weight can improve your overall health and quality of life by reducing the burden on your joints, lowering your risk of chronic diseases such as diabetes and heart disease, and enhancing your mental well-being.

Furthermore, weight loss achieved with the help of semaglutide may lead to sustained improvements in your health even after you stop taking the medication. By adopting healthier habits during your weight loss journey, such as eating a balanced diet and staying physically active, you can continue to reap the benefits of your efforts long term.How To Start Losing Weight For Men The Definitive Stepbystep Guide

Your healthcare provider can provide ongoing support and guidance to help you maintain your weight loss successes and make sustainable lifestyle changes. With the right tools and resources, you can achieve and maintain a healthier weight with the help of semaglutide and improve your overall well-being for years to come.

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The last ones always overlooked!! Genuinely losing weight in my 30's has been like being a teenager all over again, but exploring my style and clothing has also been such a healing experience for me of 2006 ❤️‍🩹 Here are some accounts that have really helped me on my voyage of discovery when it comes to enjoying fashion & finding my style: Let me know did your style change during your weightloss journey? #midsize #styleinspo #whattowear #outfitoftheday #outfitinspo #weightlossjourney #fatlossjourney #transformation

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A full body workout targeting fat loss with beginning variations and explanations.