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Dr. Riccardo De Giorgi is a Clinical Lecturer at the University of Oxford’s Department of Psychiatry and a senior psychiatric trainee with Oxford Health NHS Foundation Trust. Dr. De Giorgi is deeply engaged in clinical practice and academic research, focusing on treatment-resistant mood disorders. His work explores the role of immunological and metabolic factors in mental illness and the potential for repurposing existing medications, such as statins and GLP1 receptor agonists, to treat patients who don't respond to conventional therapies. Overall, Dr. Riccardo is a passionate educator in the field of psychiatry who is always looking at these disorders from an embodied perspective where the mind is not separate from the body. Note: When discussing ways in which compounds may enter the brain, I used the term "circumventricular brain regions" when the most appropriate way to describe it is through "circumventricular organs (CVOs). This might be too pedantic, but in Science, terminology is very important. Dr. Riccardo's work and papers discussed: GLP-1 Paper: http://doi.org/10.1038/s44220-025-00390-x Statin Paper: DOI: 10.1016/j.jad.2022.05.113 Creatine Paper: http://doi.org/10.1016/j.euroneuro.2024.10.004 Follow Dr.Riccardo's work: https://x.com/rdegiorgi https://orcid.org/0000-0001-5984-8696 Chapters: 0:00 Intro 2:14 Dr.Riccardo's research 4:07 Treatment Resistance in Psychiatry 8:07 Anhedonia and Depression 9:16 Side effects of psychiatric medications 13:43 Ketogenic diet and metabolic interventions 18:20 Do we need to target the brain to heal it? 22:45 Blood-Brain barrier 25:29 GLP-1 RAs and Anhedonia 29:35 Statins & Depression 33:24 Creatine Monohydrate 35:25 Medication and Increased Suicidality 41:06 Stigma and Perceived Uniqueness of Psychiatry 46:03 Biggest Challenges in Psychiatry 49:48 Problems in Science 51:57 Science Denial 52:50 Tips for those struggling #glp1medication #mentalhealth #metabolichealth #ozempic #psychiatry #psychology

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Semaglutide, a drug originally developed to treat type 2 diabetes, has been making headlines lately for its potential as a weight loss medication. Studies have shown that when used in higher doses, semaglutide can lead to significant weight loss in people who are overweight or obese. This has generated a lot of interest and excitement in the medical community and among individuals struggling with weight management. In this article, we will delve into the reviews of semaglutide for weight loss, exploring its effectiveness, side effects, and overall impact on individuals’ health and well-being.

Effectiveness of Semaglutide for Weight Loss

Multiple clinical trials have been conducted to investigate the effectiveness of semaglutide for weight loss. One of the most notable studies, known as the STEP trials, demonstrated that participants who received a higher dose of semaglutide experienced significant weight loss compared to those who received a placebo. The results were impressive, with some individuals losing upwards of 15-20% of their body weight over the course of the trial. This has led many experts to tout semaglutide as a game-changer in the field of weight loss medication.

Furthermore, semaglutide has been shown to not only help with weight loss but also improve other health markers, such as blood sugar levels and blood pressure. This makes it a promising option for individuals who are not only looking to shed excess pounds but also improve their overall health and reduce their risk of chronic diseases such as diabetes and heart disease.

It is important to note, however, that individual results may vary, and not everyone may experience the same level of weight loss with semaglutide. Factors such as adherence to the medication regimen, lifestyle choices, and underlying health conditions can all impact the effectiveness of semaglutide for weight loss.

Side Effects of Semaglutide

Like any medication, semaglutide is not without its potential side effects. Some individuals may experience gastrointestinal issues such as nausea, diarrhea, or constipation when taking semaglutide. These side effects are typically mild and tend to improve over time as the body adjusts to the medication. In rare cases, more serious side effects such as pancreatitis or thyroid tumors may occur, so it is important for individuals taking semaglutide to be monitored closely by their healthcare provider.

It is also worth noting that semaglutide should not be used by pregnant women or individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. These populations may be at an increased risk of experiencing adverse effects from semaglutide, so it is important to discuss any potential risks with a healthcare provider before starting treatment.

Overall, the side effects of semaglutide for weight loss appear to be manageable for most individuals, especially when weighed against the potential benefits of significant weight loss and improved health outcomes. As always, it is essential to have open and honest communication with a healthcare provider about any concerns or experiences with side effects while taking semaglutide.

Long-Term Impact of Semaglutide on Weight Management

One of the key questions surrounding semaglutide for weight loss is its long-term impact on weight management. While the initial results from clinical trials are promising, it is essential to consider how sustainable and effective semaglutide may be in the long run. Some experts are cautiously optimistic that semaglutide could help individuals achieve and maintain weight loss over the long term, especially when combined with lifestyle changes such as diet and exercise.

However, there are also concerns about the potential for weight regain once individuals stop taking semaglutide. Without continued use of the medication, it is possible that some individuals may struggle to maintain their weight loss goals. This underscores the importance of implementing healthy habits and behaviors alongside semaglutide treatment to maximize its effectiveness and ensure long-term success in weight management.

Further research is needed to fully understand the long-term impact of semaglutide on weight management and overall health. Studies are ongoing to evaluate the safety and efficacy of semaglutide over extended periods, which will provide valuable insights into its role as a weight loss medication and its potential to help individuals achieve lasting changes in their weight and health.

Cost and Accessibility of Semaglutide for Weight Loss

Another factor to consider when discussing semaglutide for weight loss is its cost and accessibility. Semaglutide is a prescription medication that may not be covered by all insurance plans, making it potentially expensive for some individuals. This could be a barrier to access for those who may benefit from semaglutide but cannot afford the out-of-pocket costs.

Additionally, semaglutide may not be readily available in all regions or healthcare settings, limiting its accessibility to individuals seeking weight loss treatment. This could pose challenges for some individuals who are interested in trying semaglutide as part of their weight loss journey but are unable to access the medication due to logistical or financial constraints.

It is important for healthcare providers, insurance companies, and pharmaceutical companies to work together to address these barriers to access and ensure that individuals who could benefit from semaglutide for weight loss have the opportunity to explore this treatment option. Collaborative efforts to make semaglutide more affordable and widely available could help improve outcomes for individuals struggling with obesity and related health conditions.

Overall, the reviews of semaglutide for weight loss are promising, with many individuals experiencing significant weight loss and improved health outcomes when using this medication. While there are potential side effects to consider and questions about long-term effectiveness, semaglutide represents a valuable treatment option for individuals seeking to manage their weight and improve their overall health. By working closely with healthcare providers and incorporating lifestyle changes, individuals can maximize the benefits of semaglutide and achieve lasting success in their weight loss journey.