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GLP-1 agonists, such as semaglutide (Wegovy), are popular medications for weight loss that work by mimicking the action of the GLP-1 hormone, which helps regulate appetite and blood sugar levels. While these medications can be very effective, some individuals might experience fluctuations in their appetite over time. If you've noticed that your appetite seems to be coming back even while on a GLP-1 agonist, you’re not alone. In this podcast, we’ll discuss why this might be happening and what you can do to manage it. Why Appetite Might Return Adaptation Over Time Body Adaptation: As you continue with the medication, your body might adapt to the drug's effects. This adaptation can sometimes lead to a gradual decrease in the medication's effectiveness in controlling hunger. Tolerance Development: Similar to other medications, the body can sometimes develop a tolerance, which may reduce the appetite-suppressing effects of GLP-1 agonists. Dietary and Lifestyle Factors Caloric Deficit: If you’ve been eating fewer calories, your body may signal hunger more strongly as it tries to maintain its energy balance. Nutrient Imbalance: Eating a diet that's lacking in essential nutrients can lead to increased hunger and cravings. Dehydration: Symptoms of mild dehydration, such as headache, fatigue, lightheadedness, and difficulty concentrating, can mimic those of hunger. You’re not getting enough sleep: Sleep is closely connected to hormonal balance, especially hormones that control hunger and fullness. When you’re sleep-deprived, leptin, which signals that you're full, drops, making you feel hungrier and more prone to overeating. Meanwhile, ghrelin, the hormone that boosts appetite, increases with lack of sleep, intensifying cravings and contributing to weight gain. Emotional and Psychological Factors Stress and Emotional Eating: High stress or emotional challenges can lead to changes in appetite and eating patterns, sometimes overriding the effects of appetite-regulating medications. Hormonal Fluctuations Hormonal Changes: Your body is pretty smart. It knows what to do to maintain itself. When you lose weight and reach a new lower weight, your body might push back. This happens because of ghrelin, the “hunger hormone”. When you lose weight, levels of ghrelin go up, making you hungry again. Tips to Help Stay Full Longer Focus on Protein Include Protein-Rich Foods: Protein can help keep you full longer by promoting satiety. Incorporate lean meats, beans, lentils, tofu, and Greek yogurt into your meals. Eat Fiber-Rich Foods Incorporate Fiber: Foods high in fiber, such as fruits, vegetables, whole grains, and legumes, can help you feel fuller for longer periods. Fiber slows down digestion and helps maintain stable blood sugar levels. But remember to start slow. Too much fiber can cause constipation. Stay Hydrated Drink Water: Sometimes thirst is mistaken for hunger. Drinking plenty of water throughout the day can help manage your appetite and prevent overeating. The general rule is to take your weight in pounds and divide the number in half. This is about how many ounces of water you should drink daily. Monitor Portion Sizes Control Portions: Eating smaller, balanced meals more frequently can help regulate hunger and prevent overeating. Be mindful of portion sizes and try to avoid large, infrequent meals. Mindful Eating Practice Mindfulness: Pay attention to your hunger cues and eat slowly. Mindful eating helps you recognize when you’re actually hungry and when you’ve had enough. Regular Physical Activity Exercise Regularly: Engaging in physical activity can help regulate your appetite and improve overall metabolism. Aim for a mix of cardiovascular, resistance, and flexibility exercises. This will help preserve lean muscle mass, which is important for maintaining a higher metabolic rate. Manage Stress Stress Reduction Techniques: To control emotional eating, incorporate stress-management practices into your routine, such as meditation, yoga, or deep-breathing exercises. Consult with Your Healthcare Provider Review Your Medication: If you’re consistently experiencing increased appetite despite following these strategies, discuss it with your healthcare provider. They might adjust your dosage or suggest an alternative treatment plan. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality...

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GLP-1 drugs like Ozempic and Wegovy are being called game-changers for weight loss — but are they really? In Episode 4 of the Health Hacks Podcast, we break down the science behind GLP-1 receptor agonists, how they work, who they’re for, and what the clinical trials don’t always tell you. What You’ll Learn: How GLP-1 drugs affect appetite and metabolism * Risks, side effects, and long-term safety concerns * Whether non-diabetics should be using these drugs * Marketing myths vs. clinical realities * Listen in for an evidence-based, hype-free look at one of the most talked-about treatments in medicine today. #GLP1Drugs #WeightLossScience #HealthHacks #Ozempic #Wegovy #PodcastMD 📖 About This Episode: Ozempic, Wegovy, Mounjaro—GLP-1 medications are everywhere. But what's the full story behind these groundbreaking drugs? In today's episode, your hosts Jennie and Jordan uncover the fascinating history, deep science, real-world results, and controversies surrounding GLP-1 receptor agonists. We’ll explore how a hormone discovered decades ago has evolved into a global phenomenon, reshaping how we tackle diabetes, obesity, and even heart disease. Plus, we'll delve into whether these medications live up to the hype—and discuss who should really foot the bill. 🗓️ Detailed Timeline: GLP-1 Drug Development & Impact 1970s–1980s: 1992: Late 1990s: 2005: 2010 2017–2021: 2022: 2023: 2024: 2025 (Anticipated): 🌟 Key Figures in GLP-1 Research: * Jens Juul Holst: Pioneered incretin hormone discoveries. * Joel Habener & Daniel Drucker: Defined GLP-1’s biological functions. * John Eng: Discovered the GLP-1 mimetic exendin-4 from Gila monster venom. * Lotte Bjerre Knudsen: Engineered liraglutide (Victoza, Saxenda). * Elon Musk: Celebrity advocate boosting public interest. 🧬 In This Episode: * The extraordinary origins of GLP-1 therapies. * How GLP-1 drugs work in the body (and why they're revolutionary). * Real-world impacts and controversies of GLP-1 medications. * Debate on healthcare coverage (Medicare, Medicaid, private insurers). * Celebrity influence and social media hype: Blessing or curse? 📝 Notable Quotes from This Episode: "Who knew a venomous lizard would become the unlikely hero in diabetes care?" – Jordan "Before you trust TikTok trends, let’s talk real science and real outcomes." – Jennie 🔖 Resources & Additional Reading: * STEP, LEADER, SELECT trial findings. * Regulatory updates from FDA, EMA, WHO. * Medicare/Medicaid policy insights and healthcare economics. 💬 Join the Conversation: We'd love your thoughts! Are these meds miracle cures or overhyped? Share your experiences, questions, or opinions in the comments below or email our team directly! 📱 Stay Connected: * Subscribe on MD TALK Substack (https://mdtalk.substack.com/subscribe) * Follow MD TALK Health & Fitness on YouTube (https://www.youtube.com/channel/UCDnfL1_Swblj5Gs83j0t6Iw/) 🎙️ Meet Your Hosts: * Jennie: Bringing curiosity and optimism, Jennie tackles health trends with enthusiasm and empathy. * Jordan: A skeptic with a sense of humor, Jordan digs beneath hype to discover scientific reality. 🏷️ Tagline: GLP-1 Drugs: Game-changing medicine or a costly craze? You decide. Disclaimer: MD TALK: Health and Fitness is produced by YourMD.Online, LLC and United Medical Group. All content is intended for educational purposes only and does not constitute medical advice. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit mdtalk.substack.com/subscribe (https://mdtalk.substack.com/subscribe?utm_medium=podcast&utm_campaign=CTA_2)

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