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In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied.   We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss.   Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Zachary Knight UCSF academic profile: https://profiles.ucsf.edu/zachary.knight HHMI profile: https://www.hhmi.org/scientists/zachary-knight Publications: https://knightlab.ucsf.edu/publications Lab website: https://knightlab.ucsf.edu X: https://x.com/zaknight Instagram: https://www.instagram.com/zknightsf LinkedIn: https://www.linkedin.com/in/zachary-knight-29a37977 Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter #HubermanLab #Health #Obesity Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://www.hubermanlab.com/disclaimer

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Tru Bio Keto Gummies have become a popular choice for individuals looking to enhance their weight loss journey. These gummies are formulated with natural ingredients like green tea extract, Garcinia Cambogia, and apple cider vinegar to help support metabolism and suppress appetite. While there are many positive reviews on the Tru Bio Keto Gummies Amazon page, it’s essential to analyze their effectiveness and user feedback to determine if they are the right fit for you.

Ingredients Analysis

Tru Bio Keto Gummies are packed with potent ingredients that are known for their weight loss benefits. Green tea extract is a powerful antioxidant that can help boost metabolism, while Garcinia Cambogia is a popular weight loss supplement that may aid in appetite suppression. Apple cider vinegar is also included in the formula to support digestion and promote overall health.

These key ingredients work synergistically to support weight loss goals when combined with a healthy diet and exercise routine. However, it’s essential to note that individual results may vary, and consistency is key when taking any supplement.

Before incorporating Tru Bio Keto Gummies into your daily routine, it’s essential to consult with a healthcare professional, especially if you have any underlying health conditions or are taking medication that may interact with the ingredients in the gummies.

User Feedback

Many users have reported positive experiences with Tru Bio Keto Gummies, noting increased energy levels, reduced cravings, and improved weight loss results. Some users have even mentioned seeing a difference in their body composition after incorporating the gummies into their routine.

However, as with any supplement, there are mixed reviews from users who did not experience the same benefits. It’s important to remember that individual responses to supplements can vary, and what works for one person may not work for another.

When looking at user feedback on the Tru Bio Keto Gummies Amazon page, it’s essential to consider all perspectives and experiences to make an informed decision about whether these gummies are right for you.

Potential Side Effects

While Tru Bio Keto Gummies are generally well-tolerated by most users, there are some potential side effects to be aware of. Some users have reported digestive issues such as bloating, gas, or stomach discomfort when first starting the gummies. These side effects typically subside as the body adjusts to the ingredients.

It’s also important to follow the recommended dosage instructions and not exceed the daily intake of Tru Bio Keto Gummies. Taking more than the recommended amount may increase the risk of experiencing adverse effects and will not necessarily lead to better results.

If you experience any persistent or severe side effects while taking Tru Bio Keto Gummies, it’s crucial to discontinue use and consult with a healthcare provider to address any concerns.

Final Thoughts

Overall, Tru Bio Keto Gummies can be a helpful tool to support your weight loss journey when combined with a healthy lifestyle. The natural ingredients in these gummies have the potential to enhance metabolism, suppress appetite, and promote overall well-being.

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However, it’s essential to approach any supplement with caution and do your due diligence by researching the ingredients, consulting with a healthcare professional, and considering user feedback. Remember that consistency is key when incorporating Tru Bio Keto Gummies into your routine, and results may vary from person to person.

Ultimately, the decision to try Tru Bio Keto Gummies is a personal one, and it’s essential to listen to your body and adjust your routine as needed to achieve your weight loss goals.

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In this exciting weight loss showdown, we dive deep into the battle of Ozempic, Mounjaro, and Wegovy! Discover how these popular medications stack up against each other in terms of effectiveness, side effects, and how they fit into your weight loss journey. We break down the science behind each treatment, discuss real user experiences, and help you determine which might be the best option for your health goals. Join us for an insightful comparison that could change the way you think about weight loss! Don’t forget to like and share this video with others seeking answers. #Ozempic #Mounjaro #Wegovy #WeightLoss #HealthJourney

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GLP-1 medications can also help with appetite dysregulation which is can mean food noise and wanting to eat despite having eaten.

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