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Welcome to The Peptide Podcast. Today we’re going to talk about something that almost everyone on a GLP-1 journey hits eventually, the weight loss plateau. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. It starts like this: you begin a GLP-1 like semaglutide or tirzepatide, and for the first few weeks or months, the weight seems to fall off. You’re eating less, not obsessing over food, and for the first time in a long time, it feels… easy. Then one day, the scale just stops moving. You’re not doing anything different. You’re still taking the meds. Still trying to eat well. Maybe you’re walking more or lifting weights. But suddenly, nothing’s happening—and the frustration kicks in. Sound familiar? Let’s talk about what’s really going on. 1. What Causes the Plateau? First of all, if you’re in this place right now: you didn’t mess up. GLP-1s are incredibly effective at reducing appetite and creating an initial calorie deficit, which is why people lose weight so quickly in the beginning. But your body isn’t just going to let that continue unchecked. It adapts. This is called adaptive thermogenesis—a fancy way of saying your body becomes more efficient. You start burning fewer calories at rest than you did before. Your resting metabolic rate actually drops beyond what you'd expect just from losing weight alone. It’s a survival mechanism. So what worked at the beginning—eating less and moving a bit more—might no longer be enough to keep the scale moving. This is totally normal. 2. Metabolism & Muscle: Why Strength Training Matters Now More Than Ever So now that we know why the plateau happens, let’s talk about things we can do to help us get over it. Something that often gets overlooked but is absolutely critical—especially if you’re on a GLP-1 or in any kind of calorie deficit. Resistance training is not optional. It’s non-negotiable. Here’s why. When you’re losing weight—whether it’s from a medication like semaglutide or just eating in a calorie deficit—your body isn’t just pulling energy from fat. If you’re not careful, it’s also going to break down lean muscle tissue. And the more muscle you lose, the slower your metabolism gets. Why? Because muscle is metabolically active tissue. It burns calories even when you’re doing absolutely nothing. So if you’re not actively sending a signal to your body to keep that muscle, it’ll start to let it go. That’s where resistance training comes in. When you lift weights or do bodyweight exercises—think squats, push-ups, resistance bands, even heavy housework—you’re telling your body: “Hey, I need this muscle. Don’t burn it for fuel.” This is especially important for those on GLP-1s because these meds reduce appetite so significantly that you might not be eating enough protein—or enough calories in general—to maintain muscle without that extra stimulus. So if you’ve hit a plateau or want to prevent one, ask yourself: Am I strength training at least two to three times a week? Am I prioritizing movements that challenge large muscle groups—like legs, glutes, chest, and back? Am I fueling my workouts with enough protein? And let me be really clear, you don’t have to become a gym rat. You don’t have to lift crazy heavy weights. But you do have to move your muscles in a meaningful, consistent way. Protecting your lean mass is one of the best ways to keep your metabolism humming—not just during your weight loss journey, but after it too. Because this isn’t about just losing weight—it’s about building a strong, metabolically healthy body that can maintain that weight loss for life. 3. Mindset Check: The Plateau Is Not a Failure Now, let’s get into the mental side of this journey—because it’s just as important as nutrition, movement, and medication. One of the biggest challenges people face—especially when progress slows—is the mental roller coaster that comes with watching the scale. And I’ll be honest: weighing yourself every single day is not ideal. Here’s why. Your body weight naturally fluctuates. Daily. And those fluctuations have nothing to do with your actual fat loss or long-term progress. Instead, the number on the scale is influenced by things like: Hydration status – If you’re slightly dehydrated, the scale may dip. But if you drank a ton of water the day before or had more salty food, it may go up due to water retention. Glycogen stores – When you eat carbs, your body stores them in your muscles and liver as glycogen, and for every gram of glycogen, your body stores about 3–4 grams of water. So a...

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A 65-year-old woman with lifelong obesity, diabetes, sleep apnea, recent cancer surgery—and now, elevated LDL and BP. Where do you begin? In this episode of Case by Case, our panel dissects a highly relatable post-op metabolic patient profile and reveals how real-world prescribing decisions evolve when balancing obesity, cardiometabolic risk, and delayed access to bariatric surgery. 💊 When should you switch from dulaglutide to tirzepatide? 🧠 Do you titrate slowly for tolerance—or fast for efficacy? 🔍 And how do you defend SGLT2 inhibitors in patients with complex risk profiles like UTIs or CKD? 📚 Key Takeaways: • GLP-1 potency comparisons: dulaglutide vs. semaglutide vs. tirzepatide • When weight loss ≠ glycemic control—and how to balance both • SGLT2 side effects: myths vs. actual contraindications • Importance of not abandoning powerful therapies too soon • Pre-surgical weight loss strategies while on a waitlist 🎓 Meet the Experts: • Dr. Marie E. McDonnell (Harvard): Expert in diabetes care delivery and obesity management. • Dr. Jan N. Basile (MUSC): Cardio-renal-metabolic educator with a primary care focus. • Dr. Nihar R. Desai (Yale): Outcomes researcher and cardiologist shaping population-level strategy. 💬 “Sometimes, the problem isn’t the patient—it’s the potency of the drug.” 🩺 Register to claim CME for this panel discussion plus more: https://www.cmemeeting.org/online-cme-courses/10th-diabetes-spring-conference 👍 Like, comment, and subscribe for expert breakdowns every episode. ________________________________________

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Taking care of yourself isn’t just about the big changes—it’s the little daily habits that make a huge difference! Here are the supplements I swear by while on my GLP-1 journey: ✨ B12: Because fatigue can be real, and B12 helps me keep my energy in check. 🍄 Mushroom Lemonade: My coffee replacement that delivers way more benefits—think focus, calm, and clean energy! 🍬 Fiber Gummies: Let’s just say, they keep things moving… just in case. 😉 💧 Collagen: Liquid collagen is my go-to for skin, hair, and joint health. Trust me, it’s worth it! 🌙 Magnesium: The unsung hero for relaxation, better sleep, and muscle health. Supplements like these help me feel my best while staying on track. 💪 Which ones are part of your routine? Let me know below! 👇 #GLP1Journey #SupplementsThatWork #WellnessTips #SelfCareRoutine

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