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Navigate the discussion with these timestamps: 0:00—Introduction to GLP-1 Drugs 08:48—Obesity as a Major Health Concern 11:52—Diabetes: The Original Indication for GLP-1 15:26—Cardiovascular Implications of GLP-1 20:16—Kidney Health and GLP-1 Mechanisms 24:02—Exploring GLP-1 Effects on Mental Health 29:27—Challenges and Side Effects of GLP-1 Treatments 42:48—Q&A Session Introduction 49:33—Conclusion and Future Directions in GLP-1 An overview of glucagon-like peptide 1 (GLP-1) drugs, their applications, and their impact on the present and future of healthcare, the economy, and society. This session provides a comprehensive overview of GLP-1 agonists and their current and future impact on healthcare. GLP-1 agonists are a class of medication that mainly helps manage blood sugar (glucose) levels in people with Type 2 diabetes and also have effects in weight management. Other than lowering blood sugar levels and reducing weight, GLP-1 agonists may also: • Lower blood pressure. • Improve lipid disorders. • Improve fatty liver disease. • Reduce the risk of heart and kidney diseases. • Delay the progression of diabetes-related nephropathy. As the market for GLP-1 drugs experiences tremendous growth, understanding their wide applications, potential risks, and effects on the economy and society is essential for anyone in the pharmaceutical and healthcare industries. What will you learn? • The history of GLP-1 receptor antagonists and their significant contribution to the treatment of diabetes. • The potential of GLP-1 drugs to treat obesity and other major health disorders. • How GLP-1 drugs function in different organ systems. • The projected economic impact of GLP-1 drugs. Who may this interest? • Pharmaceutical and biotech companies • Healthcare professionals and clinicians • Pharmaceutical researchers and scientists • Regulatory and compliance specialists Presented by Dr. Gaetano Morelli, MD, Chief Medical Officer, Altasciences: Dr. Morelli is a member of the Collège des Médecins du Québec, a Fellow of the Royal College of Physicians of Canada, certified in Internal Medicine and Gastroenterology, and a Fellow of the American College of Gastroenterology. Dr. Morelli has over 30 years of medical-clinical experience and 25 years of experience in clinical research. He joined Altasciences in 2017 as a medical advisor/consultant for complex studies. Altasciences is an integrated drug development solution company, offering pharmaceutical and biotechnology companies of all sizes a proven, flexible approach to their preclinical and clinical study needs. From lead candidate selection to proof of concept, we offer one-stop integrated formulation, preclinical and clinical manufacturing and analytical services. For over 25 years, Altasciences has been integrating into clients’ projects to help support educated, faster, and more complete early drug development decisions. Altasciences’ full-service solutions include preclinical safety testing, clinical pharmacology, bioanalysis, program management, medical writing, biostatistics, and data management, all of which can be tailored to specific sponsor requirements. Altasciences… helping sponsors get better drugs to the people who need them, faster. Visit our website to learn more: https://www.altasciences.com/

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Weekly Weigh-In: Christopher Hits His Goal! 🎉 98 lbs Down! + Laraine’s 52.4lb Loss! It’s a HUGE week on The Downsized! 🎉 Christopher has officially hit his weight loss goal for the first time and is now 98 lbs down! 🙌 Meanwhile, Laraine continues her amazing progress with 52.4 lbs lost on her GLP-1 adventure! 🚀 We’re breaking down: ✅ Christopher’s journey to 98 lbs lost and what it feels like to finally hit his goal ✅ Laraine’s continued success at 52.4 lbs down ✅ What’s next for both of us as we continue life with Zepbound, Mounjaro, and compounded tirzepatide ➡️ If you're new to our channel, we’ve lost over 150 lbs together using GLP-1s, and we share the real, raw truth of the adventure every week. 💬 Drop your wins (or struggles) in the comments—we’re all in this together! 🚢 JOIN US ON THE DOWNSIZED AT SEA CRUISE! 🚢 We’d love for you to be part of this incredible adventure! Imagine sailing the Caribbean, meeting other GLP-1 adventurers, and sharing this experience together. It’s going to be an unforgettable trip, and we’d love to see you there! More details coming soon—stay tuned! 🔔 Like, subscribe, and turn on notifications so you don’t miss a weigh-in! We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store

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Link for the Calories https://www.calculator.net/calorie-calculator.html Your weight is a very effective way to measure your health and fitness. You want to lose weight? And you need a plan. You probably have a general idea of how you’re going to do it: work out more, watch what you eat, how many calories do we have to eat in a day to lose weight, that sort of thing. But no matter how motivated you are, if you don’t have a clear step by step weight loss plan, you probably aren’t going to reach your goals. The first thing comes first; you need to figure out exactly how many calories do you need to lose weight. Today I am sharing a complete guide step by step for weight loss. These steps will help you lose inches, and keep them off permanently. This is part one of the weight loss plan series, and I am sharing a very easy and simple way of how to calculate daily calories for weight loss, with a simple calorie calculator. Although this is not a 100% accurate way, as a general rule of thumb, you will have a rough idea about your daily calorie intake. This video is in Urdu and Hindi. For my Instagram and Facebook, click below: Instagram: http://www.instagram.com/ghazalsiddiqueofficial Facebook: http://www.facebook.com/ghazalsiddiqueofficial Music Credit (and license reference) ‘Miles to Go’ Music by Jay Man www.ourmusicbox.com