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Weight Loss Effectiveness (Annual Averages): Rybelsus: ~8 percent Ozempic: ~13 percent Wegovy: ~16 percent Tirzepatide (Zepbound): ~22 percent — most effective so far. 2. Mechanism of Action: Ozempic (Semaglutide) mimics GLP-1, which: Suppresses appetite Slows gastric emptying Increases insulin Decreases glucagon This leads to lower blood sugar and reduced food intake. 3. Not FDA-Approved for Weight Loss: Ozempic is only approved for Type 2 diabetes, while Wegovy (same molecule, higher dose) is approved for weight loss. 4. Risk of Vision Loss (New Concern): Rare cases of non-arteritic anterior ischemic optic neuropathy reported. Normally: ~10 per 100,000 people With Ozempic: ~30 per 100,000 (300 percent increase) Still rare but permanent if it occurs. 5. Most Common Side Effects (~25 percent): Nausea Vomiting Diarrhea Constipation Occur in about 1 in 4 users. 6. Gallbladder Issues (2–3 percent): Rapid weight loss can lead to: Gallstones Gallbladder inflammation 7. Pancreatitis (Rare but Serious): Less than 1 percent, but can be life-threatening. Symptoms include severe abdominal pain and vomiting. 8. Thyroid Cancer Warning: Based on mouse studies, not humans. However, still contraindicated in people with MEN2 or family history of MTC. MEN2 patients almost always develop MTC by age 40. 9. Patent Timeline for Semaglutide: Core patent expires in 2026 → generics possible by 2027 Secondary patents (like pen design) expire by 2033 → price drop expected 10. Price Differences: USA: ~$1,000/month without insurance Georgia (country): ~$500 for 3 months Disclaimer: This information is provided for general knowledge and educational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult with your doctor for any questions or concerns you may have about your health.

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Akkermansia muciniphila is on the forefront of microbiome research, touted for its ability to strengthen gut barrier function and produce health-promoting short chain fatty acids. Learn from Colleen Cutcliffe, co-founder, and CEO of Pendulum Therapeutics, about the emerging science linking Akkermansia to healthy weight, intestinal integrity, and other health outcomes that may improve the way we age. In this webinar, you will learn: • Akkermansia’s important role in overall gut health and homeostasis • Emerging research on Akkermansia and metabolic diseases • Additional “boosters” to help increase the efficacy and abundance of Akkermansia —————————————————————————————————— Are you a healthcare practitioner? Consider signing up with Fullscript! https://router.fullscript.com/practitioner-signup/webinar Please note this webinar was previously recorded and hosts will not be able to respond to questions or comments after the scheduled LIVE Fullscript webinar date. Questions? Reach us at https://support.fullscript.com/ Make sure to follow us on: Facebook | https://facebook.com/fullscript Twitter | https://twitter.com/fullscriptHQ Instagram | https://instagram.com/fullscript Linkedin | https://linkedin.com/company/fullscript © Fullscript 2023. All rights reserved.

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Join Dr. Rachele as she answers all your questions about Weight Management at Restore! In this video, you'll learn about our customized weight loss treatment plans, how GLP-1 medications like semaglutide work for weight loss and the benefits of personalized care. Discover how Restore uses cutting-edge therapies to help you reach your health goals. 💡 Topics Covered: • What is Weight Management at Restore? • GLP-1 hormones & weight loss medications • Importance of blood work and contraindications • Personalized wellness with Restore Let us help you develop a plan specifically tailored to your needs and goals. Schedule your consultation today at www.restore.com Disclaimer: Supply of compounded medications may change due to fluctuations in pharmacy stock and changing FDA regulations. In the event of a supply shortage, you may not be able to access certain compounded medications.