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New evidence brings more good news about the unanticipated effects of the GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt -- TRANSCRIPT -- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. It’s quite a thing that we live in an era with the biggest blockbuster weight-loss drugs in history, and I can look at you straight-faced and say, yeah, but honestly that’s not the most interesting thing about the GLP-1 receptor agonists such as Ozempic. Beyond their clear utility in weight loss, we have good data that demonstrate the drugs lead to improvements in rates of heart disease, liver disease, and even all-cause mortality, and intriguing reports of strange off-target effects: a reduction in gambling, drinking, drug use, smoking, and compulsive shopping. It’s honestly hard to find an organ system or self-destructive behavior that GLP-1 drugs don’t seem to improve somehow. It’s almost strange. It’s as if the statins came out and everyone was excited about the cholesterol going down, and then we discovered that they reversed hair loss or took three strokes off your golf game. How does one drug do so many things? I think the behavioral changes are the clue. The fact that people may drink or smoke less on these drugs should tell you that something is happening in their brains. And if these drugs are acting on the brain, you might well wonder if they can reduce the risk for brain disease — dementia. And, at least according to a new study, the answer appears to be yes. As the GLP-1 drugs started getting more and more popular, I decided to perform some due diligence and refresh what I had learned in med school about this thing called “glucagon-like peptide.” These drugs bind to the same receptor that GLP does, primarily to cause the pancreas to release more insulin when blood sugar is high. But we have plenty of drugs that stimulate insulin release. And they don’t seem to have all these other weird effects. So, what’s going on? When a drug acts on a specific receptor, it is worth seeing what cells in the body have that receptor, and this is a pretty interesting figure that shows that. You see high expression in the pancreas — no surprise. But next is expression in the heart muscle — interesting, considering these drugs have been shown to reduce the risk for heart disease. Then the salivary glands, and then… the cerebral cortex. The brain. And not just any part of the brain, the thinking part of the brain. A lot happens when these drugs bind to a receptor on a cell. But the brain is a mysterious and important organ. In contrast, the heart is relatively simple, and there are multiple randomized trials that show that GLP-1 drugs, as well as some other drugs for diabetes, such as the SGLT2 inhibitors, pioglitazone, and metformin, reduce the risk for cardiovascular disease in people with diabetes. So, it makes sense to ask whether these drugs would do the same for brain disease. Enter this study, "Cardioprotective Glucose-Lowering Agents and Dementia Risk," from Catriona Reddin and colleagues in JAMA Neurology. It’s an impressive bit of work combining data from 23 different randomized trials of these drugs including more than 150,000 individual people, to determine whether they reduce the risk for dementia. This is the best evidence we have to date for a neuroprotective effect of GLP-1 inhibitors. And this is the only type of study that could give us this evidence. The reason you need to combine so much data to detect a signal is that, to date, no randomized trials of GLP-1 drugs have been designed with dementia as a primary outcome. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt

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“So, we have Adoulla who is originally from Cyprus - you can tell from that lovely tan – and she’s just come back from there, which is why she’s nice and brown! You had really good results, didn’t you, on your 1st review – how many pounds did you lose?” “I lost 9 lbs”, replies Adoulla. “That’s a good start – and inches as well?”. “I lost 4.75 ins”, responds Adoulla. “And lots of body fat – how much body fat did you lose?” “1.6 % body fat”, replies Adoulla. “That’s about double what we’d expect, so that’s absolutely brilliant!” “I’m very happy”, smiles Adoulla. When asked whether she was enjoying the workout, Adoulla commented, “Yes I am, I’m really enjoying it. Everybody’s very friendly and it’s a nice atmosphere to workout and it’s not really a chore – I really enjoy it.” “It’s quite quick as well, isn’t it – 30 minutes, in and out. Did you manage to get to grips with the machines ok?” Adoulla replied, “Yeah, I’m nearly there, I’m a bit slow, it took me a while, but yeah, I’m getting there now.” “Excellent, well done, so we’re going to work you hard on your workout review today, get your reps targets and get you pushing! Fantastic, enjoy your workout and thanks for talking to us today.” Good work Adoulla!

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Sheryl Underwood, the beloved comedian and television host, has been making headlines recently for her impressive weight loss journey. Fans have noticed a significant change in her appearance and are eager to learn more about the strategies she’s used to achieve her results. In this article, we’ll explore Sheryl Underwood’s weight loss journey, including the strategies she’s employed and the impressive results she’s achieved.

Sheryl Underwood’s Motivation

Like many individuals on a weight loss journey, Sheryl Underwood was motivated by a desire to improve her health and overall well-being. She has been open about her struggles with weight in the past and decided to make a change for the better. In addition to improving her physical health, Sheryl’s weight loss journey has also been motivated by a desire to inspire and motivate others who may be facing similar challenges.

Sheryl’s dedication to her weight loss goals is evident in her commitment to making healthier choices and sticking to a consistent exercise routine. She understands the importance of self-care and has made it a priority in her daily life. By staying focused on her goals and maintaining a positive mindset, Sheryl has been able to stay on track and make significant progress on her weight loss journey.

Strategies for Success

One of the key strategies that Sheryl Underwood has used to achieve her weight loss goals is making healthier food choices. She has emphasized the importance of incorporating more fruits, vegetables, and lean proteins into her diet, while also reducing her intake of processed and high-calorie foods. By focusing on nourishing her body with wholesome foods, Sheryl has been able to fuel her workouts and maintain her energy levels throughout the day.

In addition to making changes to her diet, Sheryl has also prioritized regular exercise as a crucial component of her weight loss journey. She has embraced a variety of workouts, including cardio, strength training, and yoga, to keep her body moving and build strength. By staying active and challenging herself with new exercises, Sheryl has been able to tone her body and improve her overall fitness level.

Results and Progress

Sheryl Underwood’s dedication to her weight loss journey has paid off, as she has seen impressive results in a relatively short amount of time. Fans have been quick to notice the transformation in her appearance, as she has slimmed down and toned up her body. Sheryl’s commitment to her health and wellness goals has not gone unnoticed, and she has received an outpouring of support and encouragement from fans and followers.

By staying consistent with her healthy habits and staying focused on her goals, Sheryl has been able to achieve the results she desired. She has not only lost weight but has also gained confidence and a renewed sense of self-esteem. Sheryl’s journey serves as a reminder that with dedication, hard work, and perseverance, anyone can achieve their weight loss goals and improve their overall well-being.

Final Thoughts

Sheryl Underwood’s weight loss journey is an inspiring example of what can be achieved with dedication, commitment, and a positive mindset. By making healthier choices, prioritizing regular exercise, and staying focused on her goals, Sheryl has been able to transform her body and improve her overall well-being. Her journey serves as a source of inspiration and motivation for others who may be on a similar path, showing that with hard work and determination, anything is possible. As Sheryl continues on her weight loss journey, fans can expect to see even more impressive results and a continued commitment to her health and wellness goals.