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Paper: https://doi.org/10.1126%2Fscience.adj2537 Chapters 0:00 – Culinary Kryptonite 1:06 – GLP-1 preingestive satiation 2:46 – DMH is the brain region involved in preingestive satiation 4:14 – Heterogeneity: Rainbows and Froot Loops 5:58 – Anti-Responder? 7:13 – There’s always room for ice cream 10:29 – My prescriptions Optogenetics breakdown (go to 3 min 19 sec) in this video: https://youtu.be/44qM9VtNAjc Video Sponsor(s) - House of Macadamia and RxSugar Yes, I’m wearing a Mac Monster Macadamia Nut Shirt! I’ve been a heavy user of highly satiating macadamia nuts for over 5 years since I started a ketogenic diet. They’re delicious, versatile, high MUFA, high Omega-7/Palmitoleic Acid, low Omega-6/Linoleic acid, and low oxalate, phytate and lectin. To try product from my favorite nut company, HouseOfMacadamia, Go To: http://partner.houseofmacadamias.com/nick-norwitz - 15% Off All Bundles - 10% off any item (non-bundle) with code "NICK10" And for more information on macadamia nutrition and Omega-7: https://youtu.be/Vngn6i-rmZI I'm also on the scientific advisory board at RxSugar, a company that specializes in allulose. Unlike macadamia - which I do consume regularly - I don't have much of a sweet tooth so don't find I have much of a need for allulose. However, I always try my best to separate my personal preferences from the science, which is why I'm happy and proud to support RxSugar and their mission to displace fructose and sugar in the food supply with allulose! Among allulose's interesting properties is that it induces the release of endogenous GLP-1, albeit at lower dose equivalencies than prescription medications. Still, there are data (clinical and preclinical) that allulose can have anti-obesogenic properties. And the precise mechanism is being explored actively! There are also clinical reports of people have loss of cravings and "food noise" with allulose products, which is interesting. I wonder if one could measure a change in DMH pre-ingestion satiation neurons after an allulose bolus... perhaps we will find out in time! You can use my discount code NICK20 for 20% off any products. https://rxsugar.com For more scientific information on allulose, go here: https://youtu.be/pr93EsEV2bM

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