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In this week’s episode, Dr. Mary and Dr. Lucy continue their exploration into the world of supplements. The spotlight is on the fascinating compound Berberine—a natural supplement that’s gaining widespread attention for its potential to improve insulin resistance, support cholesterol management, and enhance overall metabolic health. Listeners will gain a deeper understanding of how Berberine works, its science-backed benefits, and practical tips for incorporating it into a health-focused lifestyle. Berberine Overview ✨ Origin: A bioactive compound extracted from various plants, particularly the barberry plant, used in traditional Chinese and Ayurvedic medicine for centuries. ✨ Mechanism of Action: Activates the AMPK pathway, a critical regulator of cellular energy metabolism, improving how the body processes and utilises energy. ✨ Modern Interest: Recently studied for its effects on metabolic health, including insulin resistance, type 2 diabetes, obesity, and cardiovascular health. Key Benefits ✨ Improved Insulin Sensitivity: 📍Enhances glucose uptake into cells and improves insulin signalling. 📍Similar to the effects of metformin. 📍Supports better blood sugar control and energy utilisation. ✨ Anti-Inflammatory Effects: 📍Reduces inflammation by inhibiting inflammatory pathways and cytokines. 📍Breaks the cycle of insulin resistance and inflammation. ✨ Cholesterol Management: 📍Lowers LDL cholesterol by inhibiting PCSK9 enzymes. 📍Promotes better cholesterol recycling and utilisation. ✨ Gut Microbiome Health: 📍Encourages growth of beneficial gut bacteria, similar to metformin. 📍Influences metabolic health positively via gut microbiome changes. ✨ Liver and Muscle Benefits: 📍Helps the liver process glucose more effectively. 📍Improves glucose utilisation in muscle cells. ✨ Polycystic Ovarian Syndrome (PCOS): 📍Improves ovulation by enhancing insulin sensitivity in ovaries. 📍Potentially aids fertility when combined with other ovulation-inducing medications. Safety and Considerations ✨ Side Effects: 📍Common issues: Diarrhea, constipation, and stomach cramps. 📍Shares similar gastrointestinal effects with metformin. ✨Interactions with Medications: 📍Metabolised via the CYP450 liver enzyme system. 📍Potential interactions with other medications processed by the same pathway. 📍Caution for those on glucose-lowering drugs due to potential low blood sugar risks. ✨ Pregnancy and Breastfeeding: 📍Lack of safety data for use during pregnancy or breastfeeding. 📍Should not be used due to potential risks to the fetus or baby. ✨ Illness and Stopping Use: 📍Like metformin, berberine might need to be stopped temporarily during significant illness to avoid complications like acidosis. ✨Product Quality: 📍Supplements vary widely in quality. 📍Avoid products with additives like maltodextrin, sunflower oil, or high alcohol content. 📍Choose supplements with minimal, clean ingredients. ✨ General Recommendations 📍Treat berberine like a medication: targeted, monitored, and with medical supervision. 📍Take it with food for the best absorption. 📍Not a standalone solution: Combine with lifestyle changes for best results. 📍Avoid excessive or unmonitored use to prevent potential risks. ✨ Final Verdict 💃 Cautious Yay: Promising benefits backed by solid evidence for improving insulin resistance and metabolic health. 💃 Supervision Advised: Should be used thoughtfully, particularly if combined with other medications or for specific conditions like PCOS or diabetes.

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These drugs may melt fat—but they could be breaking down much more. Here’s the truth behind GLP-1s that most people aren’t hearing. Struggling to study? 🚀 Learn the proven techniques that rocketed me from a 1.7GPA to Board-Certified Surgeon! Check out Study Hackers now: http://www.studyhackers.com 📚🔥 SUBSCRIBE: @drbuckparker Dr. Buck Parker, MD is a Board Certified General Surgeon and can be found here online here: IG: @drbuckparker Twitter: @drbuckparker FB: facebook.com/drbuckparker Website: www.drbuckparker.com Store: www.scrublifesupplyco.com

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Resources for the Community: ___________________________________________________________________ https://linktr.ee/theplussidezpodcast Ro - Telehealth for GLP1 weight management https://ro.co/weight-loss/?utm_source=plussidez&utm_medium=partnership&utm_campaign=comms_yt&utm_content=45497&utm_term=55 ______________________________________________________________________ In this episode, we’re diving into Ro’s innovative approach to weight management with Dr. Steve Silvestro, Associate Director of Clinical Content & Education, and exploring why now is a critical time to discuss telehealth weight loss solutions. With the shortage of Tirzepatide and semaglutide behind us, patients may face more difficulty finding safe, regulated, compounded GLP-1 medications. Many may even consider turning to the black market to obtain research-grade GLP-1s, but it’s important to understand the risks involved. Ro offers a regulated and safe alternative: Zepbound vials, which can be prescribed at almost the same cost as compounded tirzepatide, with the added benefit of medical oversight. Dr. Silvestro shares how Ro’s personalized care model works to help patients navigate insurance prior authorizations for Zepbound, ensuring a smoother path to treatment. We also hear from two Ro patients, Colleen and Billy, who share their personal community stories and experiences with Ro’s platform. They talk about how Ro’s holistic approach—addressing everything from diabetes prevention to thyroid conditions like hypothyroidism and Hashimoto’s disease—has empowered them to tackle their weight loss journeys and find sustainable health improvements. Ro's approach goes beyond just medication. With a focus on both physical and mental health, they create tailored treatment plans that consider each patient’s unique challenges and provide long-term success. If you’re looking for insights on safe weight loss solutions, GLP-1 medications, or navigating the complex world of weight management, this episode has you covered. Follow our guests! Billy Facebook: https://www.facebook.com/share/1687JSFHSa/?mibextid=wwXIfr LinkedIn: https://www.linkedin.com/in/billyscharmann?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=ios_app iG: https://www.instagram.com/bill Kim Carlos, Executive Producer TikTok https://www.tiktok.com/@dmfkim?is_from_webapp=1&sender_device=pc Instagram https://www.instagram.com/dmfkimonmounjaro?igsh=aDF6dnlmbHBoYmJn&utm_source=qr Kat Carter, Associate Producer TikTok https://www.tiktok.com/@katcarter7?is_from_webapp=1&sender_device=pc Instagram https://www.instagram.com/mrskatcarter?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==

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😩 "Calories In, Calories Out" isn't the whole story when it comes to weight management. It's not always straightforward, as our bodies are complex and we can’t ignore other factors like hormones, metabolism and the quality of our nutrition. ⚠️ Hormones are key messengers controlling hunger, energy storage, and how we react to food, so any disruptions can impair the body's ability to recognize hunger and fullness ⚠️ Slower metabolism often means fewer calories are required to maintain the same weight, so it is important to adapt our dietary habits to these changes. ⚠️ Calories aren't created equal - calories from nutrient-rich foods are better for your health than the same amount of calories from processed foods Let's explore a more holistic approach to weight management! NOVI Optimum Plus, our medicated weight loss program provides support from doctors and health coaches to help you lose weight sustainably. #weightloss #weightlosstips #weightlossjourney #fatloss #metabolism #hormones #leptin #ghrelin #nutrition #healthylifestyle #NOVIHealth #BetterHealthTogether

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