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(USMLE topics) Methamphetamine: mechanism of action, short-term and long-term effects, addiction and overdose. Purchase a license to download a non-watermarked copy of this video on AlilaMedicalMedia(dot)com ©Alila Medical Media. All rights reserved. Voice by: Ashley Fleming All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. Methamphetamine, also called meth or crystal meth, among other names, is a psychostimulant drug mainly known for its recreational use. Methamphetamine is chemically similar to amphetamine, a drug used to treat attention-deficit hyperactivity disorder, obesity and narcolepsy; but being more potent and highly addictive, methamphetamine is rarely prescribed for medical treatments. Most commonly, the drug is produced illegally, from pseudoephedrine, an ingredient in cold medicines. It can exist as white powder, pills, or bluish-white crystals, and can be consumed by swallowing, smoking, snorting, or injecting. Methamphetamine acts to increase the amount of a neurotransmitter called dopamine in the brain. Dopamine is at the basis of the brain reward pathway, which is designed to “reward” the body for important behaviors that are essential for survival, such as feeding when hungry. Engaging in enjoyable activities causes dopamine release from dopamine-producing neurons into a space between neurons, where it binds to and stimulates its receptors on the neighboring neuron. This stimulation is believed to produce pleasurable feelings or rewarding effect. Normally, dopamine molecules are promptly cleared from the synaptic space to ensure that the postsynaptic neurons are not over-stimulated. This is possible thanks to the action of dopamine-transporter, which channels dopamine back to the transmitting neuron. Methamphetamine binds to dopamine-transporter and blocks dopamine re-uptake. In addition, it can enter the transmitting neuron and trigger more dopamine release. The result is that dopamine builds-up in the synapse to a much greater amount than normal. This produces a continuous over-stimulation of receiving neurons and is responsible for the prolonged and intense euphoria experienced by drug users. At a low dose, methamphetamine stimulates the brain and can elevate mood and alertness; and by accelerating heart rate and breathing rate, it increases energy in fatigued individuals. It also reduces appetite and promotes weight loss. These seemingly “positive” effects keep users coming back for more, eventually leading to addiction and potential overdose. Long-term drug users may experience extreme weight loss, severe dental damage, and constant hyperactivity which results in anxiety, sleeping disorders and violent behaviors. Overdose takes the drug’s effects to the extreme and can cause psychosis, heart attacks, seizures, strokes, organ failures, and even death. Currently, there is no approved pharmacological treatment for methamphetamine addiction; the most effective treatments are cognitive behavioral therapies.

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Semaglutide is a medication that has gained popularity in recent years for its effectiveness in weight loss. For those looking to explore this option, finding a clinic that offers Semaglutide weight loss near you can be key to starting your journey towards a healthier lifestyle. In this guide, we will provide information on what Semaglutide is, how it works, and where you can find clinics near you that offer this treatment.

Understanding Semaglutide Weight Loss

Semaglutide is a prescription medication that is used to help people lose weight. It works by mimicking the effects of a hormone called GLP-1, which is naturally produced in the body and helps regulate appetite and food intake. By activating the GLP-1 receptors in the brain, Semaglutide can help reduce hunger and increase feelings of fullness, leading to a decreased caloric intake and ultimately weight loss.

One of the key benefits of Semaglutide is its ability to target the areas in the brain that control appetite, making it a powerful tool for those struggling to lose weight through diet and exercise alone. Studies have shown that Semaglutide can lead to significant weight loss in a relatively short amount of time, making it a promising option for individuals looking to achieve their weight loss goals.

Finding Semaglutide Weight Loss Clinics Near You

If you are interested in exploring Semaglutide weight loss as a treatment option, it is important to find a clinic near you that offers this service. Many healthcare providers have started to incorporate Semaglutide into their weight loss programs, recognizing its effectiveness in helping patients achieve their weight loss goals.

When looking for a Semaglutide weight loss clinic near you, it is important to consider factors such as the expertise of the healthcare providers, the cost of treatment, and the success rate of previous patients. It is also important to ensure that the clinic follows all necessary safety protocols and guidelines to ensure your health and well-being throughout the treatment process.

Benefits of Semaglutide Weight Loss Treatment

There are many benefits to choosing Semaglutide weight loss treatment as a method for achieving your weight loss goals. In addition to its ability to reduce hunger and increase feelings of fullness, Semaglutide has been shown to improve other aspects of health, such as blood sugar control and cholesterol levels.

Furthermore, Semaglutide is a once-weekly injection, making it a convenient option for individuals with busy lifestyles. The medication is also well-tolerated by most patients, with few side effects reported. Overall, Semaglutide offers a safe and effective way to jumpstart your weight loss journey and achieve long-lasting results.

Risks and Considerations of Semaglutide Weight Loss Treatment

While Semaglutide is generally considered to be a safe and effective weight loss treatment, there are some risks and considerations to keep in mind. Some potential side effects of Semaglutide may include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.

It is also important to monitor your blood sugar levels regularly while taking Semaglutide, as the medication can affect insulin production in the body. Additionally, Semaglutide may not be suitable for everyone, such as pregnant or breastfeeding women, individuals with a history of pancreatitis, or those with certain pre-existing medical conditions.

Conclusion

In conclusion, Semaglutide weight loss treatment offers a promising option for individuals looking to achieve their weight loss goals. By understanding how Semaglutide works, finding a reputable clinic near you, and weighing the benefits and risks of treatment, you can make an informed decision about whether Semaglutide is the right choice for you.

Remember to consult with a healthcare provider before starting any new weight loss treatment to ensure that it is safe and appropriate for your individual needs. With the right support and guidance, Semaglutide weight loss treatment can help you take control of your health and achieve long-lasting results.





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The ketogenic diet has gained a lot of popularity in recent years because of its many health benefits such as weight loss, improved mental clarity and energy levels. The low carbohydrate high fat (LCHF) diet forces the body to burn fats as opposed to carbohydrates thus putting it into ketosis. Additionally, it is claimed that apple cider vinegar (ACV) could potentially bring about weight loss, better digestion and blood sugar regulation. When properly combined, keto and ACV can form a powerful tandem which boosts either’s effect.

Decoding the Keto Diet

Ketogenic diets entail radically reducing your carb intake and substituting healthy fats for them. This leads your body to a state of ketosis whereby instead of glucose; it burns fats for fuel. This metabolic state can result in rapid weight loss, sustained high energy levels as well as increased concentration. Notably enough, the keto diet decreases inflammation, lowers blood sugar levels and improves other health markers.

However beneficial the keto diet may be, it may be difficult to sustain especially during the early stages of adaptation. Most people encounter problems like craving carbs or not having enough energy or abiding by strict macronutrient ratios. However if you would incorporate ACV gummies into your routine everyday this might boost effects of keto diet while alleviating some of these issues.

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For hundreds of years now apple cider vinegar has been used due to its wide range of health benefits that it has been shown to have towards humans beings. It is rich in acetic acid which promotes fullness thereby enhancing weight loss as well as reduction in fat storage according to researches done on both animals and human beings (Samuel et al., 2008). As well, ACV helps control blood sugars digestion and enhances immunity against diseases respectively. It also contains antimicrobial compounds such as flavonoids that fight off pathogenic bacteria thereby improving gut health.

Apple cider vinegar is a potent natural remedy that many individuals find difficult to incorporate into their daily routines due to its pungent flavor and acidity. ACV gummies provide a convenient alternative way of consuming this powerful ingredient. You can allegedly achieve your health goals more quickly by combining the benefits of keto with those of ACV.

Benefits Of Combining Keto And ACV Gummies

When combined, keto diet and ACV gummies create a synergistic effect which could lead to weight loss, better digestion and improved general wellbeing. Acetic acid present in apple cider vinegar helps suppress hunger making it easier for them to adhere to the low carbs requirements imposed by the ketogenic diet (Sakakibara et al., 2006). In addition, ACV has been found to ensure proper regulation of glucose levels leading to decreased inflammation as well stable blood sugar levels or even protection against diabetes.

Moreover, mixing keto with ACV gummies may support gut health through promoting growth of good bacteria while killing bad ones. This causes better absorption of nutrients into the body; reduced bloating and easing digestion problems. By incorporating these two powerful natural ingredients into your daily routine, you may be able to get even more out of them and improve your health overall.

How To Use Keto And Acv Gummies In Your Routine

To enjoy the benefits of both keto and ACV gummies, it is important to follow a well-formulated ketogenic diet and buy high-quality ACV gummies. Look for organic apple cider vinegar in products that are free from artificial additives, and preservatives. Start with one or two ACV gummies per day and increase as needed.

It is essential to stay hydrated, get enough rest and engage in regular physical activity for optimum results from keto and ACV gummies. Respond accordingly depending on the signals your body gives you so that you do not have to perform in a predetermined way. Thus, by using dedication and perseverance, you will be able to attain them.

Conclusion

In conclusion, synergy between keto and ACV gummies could lead to weight loss acceleration, digestive improvement as well as enhancement of overall health. Adopting a well-formulated ketogenic diet together with quality ACV gummies can possibly make your efforts yield faster results towards your health objectives. Follow what your body tells you while still staying firm within our routine by adjusting whenever it may become necessary depending on personal needs. Dedication and persistence would thus put these elements into action thereby reaping their numerous benefits.

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Emily King is an online fitness coach, IFBB Pro Athlete & Mum. In this over saturated and ever growing fitness world, losing fat and building muscle whilst managing your life, job, relationships and kids seems to be getting ever more difficult as we become more time poor, distracted & misinformed... Emily and their industry leading coaches help busy people get results through sustainable, flexible and evidence based methods. Expect to learn, how you can navigate a fitter lifestyle as a parent by making small realistic changes, some of the biggest myths about losing fat, a simplified approach to what it really takes to getting into shape, where people go wrong when thinking about using performance enhancing drugs and much more... Links: King Bodies Website: https://kingbodies.com/ Emily's Instagram: https://www.instagram.com/emily_kingbodies/ _ Get in touch here in the comments below or visit our website here: https://www.fearlesstrainingunited.com