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📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com and/or 📢 Become an Insider, Ben’s website: https://www.benbikman.com In this episode of the Metabolic Classroom, Dr. Ben Bikman explores a surprising and controversial dietary trend: the “sugar diet.” Despite its name, this diet isn’t built around candy and soda. Instead, it promotes a very high intake of simple carbohydrates—primarily from natural sources like fruit, honey, and juices—while restricting both protein and fat to below 10% of total calories. This unusual approach has been gaining popularity, especially among lean, athletic men, some of whom report improved energy, body composition, and insulin sensitivity. Ben traces the diet's philosophical roots back to the 1930s rice diet used for managing kidney and heart disease, noting how both rely heavily on low-protein, high-carbohydrate intake. He reviews studies in both animals and humans showing that the key metabolic shifts—such as increased mitochondrial uncoupling, fat loss, and improved glucose control—may not be due to the sugar itself, but rather to the restriction of protein. This triggers a spike in FGF21, a liver hormone that enhances energy expenditure and metabolic health. The lecture also examines the limitations of this approach. Dr. Bikman points out that the diet appears to work only under very specific conditions: in metabolically healthy individuals, especially men, with high physical activity levels. For others, particularly those prone to insulin resistance, food addiction, or poor satiety control, such a high-sugar diet could be problematic. He emphasizes that, as with all dietary interventions, context matters. Ultimately, this lecture doesn’t promote the sugar diet but uses it as a lens to highlight the underestimated power of protein restriction in driving hormonal and mitochondrial adaptations. Dr. Bikman urges caution and encourages further exploration of how individual physiology responds to dietary extremes. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Dr Bikman. It also includes Ben’s Research Review Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. #SugarDiet, #ProteinRestriction, #InsulinResistance, #FGF21, #MetabolicHealth, #LowProteinDiet, #HighCarbDiet, #RiceDiet, #WeightLossScience, #BenBikman, #MitochondrialHealth, #NutritionTrends, #FatLoss, #Ketones, #LowFatDiet, #InsulinSensitivity, #ModernDiets, #DietExperiments, #HormonalHealth, #MetabolismResearch #drbenbikman Timestamps (approximate): 01:00 – What the Sugar Diet Really Is 03:00 – Historical Comparison: The Rice Diet 06:00 – Kempner’s Research and Calorie Restriction 08:30 – Similarities Between Rice and Sugar Diets 10:00 – What the Research Says (or Doesn’t) 11:30 – 2016 Animal Study on Low Protein, High Carb 13:45 – 2022 Human Trial: Protein vs. Calorie Restriction 16:45 – Why Sugar Diet May "Work" for Some 19:00 – Risk of Addictive Eating and Gender Considerations 21:45 – Satiety and Hunger: What’s the Science? 24:50 – Potential Mechanism: FGF21 28:15 – 2025 Study on Protein Restriction and Uncoupling 31:10 – Additional Mechanisms: AMPK, mTOR, GH 34:45 – A Fat-Based Version of the Sugar Diet? 35:43 – The Problem with Focusing on Non-Essential Nutrients Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd

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