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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt
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The keto food plan has become popular in recent years due to its promise of losing weight and other health benefits. However, sticking to a strict keto diet can be tough for many people because it limits the intake of carbohydrates that they eat. This is where keto gummies like Keto Flo Gummies enter the picture. These gummies claim to help people reach ketosis, a metabolic state in which your body burns fat instead of carbohydrates for energy. But do they really work? In this article, we will explore the science behind ketosis and examine whether Keto Flo Gummies can help you reach your health and weight loss goals.
Understanding Ketosis
Before getting into whether or not Keto Flo Gummies are effective, it’s important to know what ketosis is and how it functions. Ketosis is a normal metabolic state that develops when there are not enough carbohydrates in your body to use as fuel. When there are no carbs available, the body starts breaking down fats into substances known as ketones which then acts as energy source for cells. This leads to weight loss and increased energy levels and has made it a popular choice among those who want to lose some extra pounds.
The Role of Keto Supplements
While the ketogenic diet is effective in achieving ketosis, many individuals find it challenging to maintain due to its restrictive nature. This is where keto supplements like Keto Flo Gummies can be beneficial. Generally these gummies contain exogenous ketones, MCT oil among others intended to help easily attain ketosis by the body when supplemented with these ingredients resulting in rapid weight loss.
Effectiveness of Keto Flo Gummies
So do Keto Flo Gummies actually work? The efficiency of any keto supplement may vary from person-to-person and according to quality. Some researches have shown that consuming exogenous ketones along with MCT oil facilitates weight loss while also improving general metabolic health. Nevertheless, these supplements are not magic cures; hence should be taken while under a healthy diet and exercise.
Potential Side Effects
Even though keto supplements such as Keto Flo Gummies may have some benefits to some people, they can also come with certain side effects. The common adverse effects of achieving ketosis are tiredness, headaches and problems with your digestive system. In addition, the high fat content in ketogenic diets may lead to raised cholesterol levels in some individuals. As such, anyone particularly those with other health conditions should seek guidance from a healthcare practitioner before commencing any new supplement program on their own.
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In conclusion, Keto Flo Gummies could help some people achieve ketosis and experience the advantages of the ketogenic diet. However, they will not replace maintaining a healthy lifestyle that involves eating well balanced meals and regular exercises. If you consider using these gummies on yourself then ensure to do enough research on it and consult your healthcare provider for advice on whether you can take it or not. Ultimately, successful weight loss and better health depend on finding a sustainable approach that suits you personally.
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Day 1 of the 7-Day Fat Loss Bodyweight Workout Series is here! This beginner-friendly, full-body workout is perfect for burning fat and getting you moving. No equipment is needed—just 10 minutes of your time. Follow along and let’s crush this challenge together! Don’t forget to like, comment, and subscribe for the rest of the challenge. Working for 30 seconds and resting for 10 seconds. Please share this workout with your friends and family, hit subscribe and let's get as many people as possible working out together. ----- Instagram -  / @B.palmer_ TikTok -  / @B.palmer_ Facebook - / Brandon Palmer Business Email: [email protected]
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BioLyfe Keto is a revolutionary new product that is taking the weight loss industry by storm. With its cutting-edge technology and scientific precision, BioLyfe Keto is changing the way we think about weight loss and body transformation. This innovative product utilizes biological precision to target fat cells and promote rapid, sustainable weight loss. If you are tired of struggling with traditional diet and exercise programs that just don’t seem to work, BioLyfe Keto may be the solution you’ve been looking for.
Understanding Biological Precision
One of the key features of BioLyfe Keto is its focus on biological precision. Traditional weight loss methods often rely on general principles that may not work for everyone. BioLyfe Keto, however, uses cutting-edge technology to analyze your unique biological makeup and create a customized weight loss plan that is tailored to your individual needs. By targeting fat cells at the molecular level, BioLyfe Keto can help you achieve your weight loss goals more quickly and effectively than ever before.
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With BioLyfe Keto, you can say goodbye to one-size-fits-all weight loss plans that may not work for your body. By harnessing the power of biological precision, BioLyfe Keto can help you achieve results that are truly transformative. Whether you are looking to lose a few pounds or make a significant lifestyle change, BioLyfe Keto can help you reach your goals with precision and efficiency.
The Science Behind BioLyfe Keto
At the heart of BioLyfe Keto’s revolutionary technology is the science of ketosis. Ketosis is a natural metabolic state in which the body burns fat for energy instead of carbohydrates. By inducing ketosis through a carefully curated blend of ingredients, BioLyfe Keto can help your body burn fat more efficiently and effectively than ever before. This means that you can see results faster and more consistently than with traditional weight loss methods.
By targeting fat cells and promoting ketosis, BioLyfe Keto can help you achieve sustainable weight loss that lasts. With its unique approach to weight loss, BioLyfe Keto is helping people all over the world transform their bodies and their lives. If you are ready to take control of your weight and your health, BioLyfe Keto may be the solution you’ve been searching for.
The Benefits of BioLyfe Keto
In addition to promoting rapid weight loss through ketosis, BioLyfe Keto offers a range of other benefits as well. For example, many users report increased energy levels and mental clarity when using BioLyfe Keto. This is because ketosis can help stabilize blood sugar levels and provide a steady source of energy throughout the day. By using BioLyfe Keto, you may find that you have more energy, focus, and motivation to tackle your weight loss goals.
Furthermore, BioLyfe Keto can help curb cravings and reduce hunger, making it easier to stick to your weight loss plan. Many users find that they feel more satisfied and full after using BioLyfe Keto, which can help prevent overeating and snacking. By promoting a sense of satiety and satisfaction, BioLyfe Keto can help you stay on track and achieve your weight loss goals more effectively.
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If you are ready to transform your body with biological precision, BioLyfe Keto is the perfect solution for you. With its innovative technology, scientific approach, and proven results, BioLyfe Keto is changing the way we think about weight loss. Say goodbye to ineffective diet plans and endless hours at the gym – with BioLyfe Keto, you can achieve the body of your dreams more quickly and easily than ever before. Try BioLyfe Keto today and experience the transformative power of biological precision.
FAQ
Q: How quickly can I expect to see results with BioLyfe Keto?
A: Results may vary, but many users report seeing noticeable changes within the first few weeks of using BioLyfe Keto. With consistent use and adherence to the recommended dosage, you can expect to see significant weight loss and body transformation over time.
Q: Are there any side effects of using BioLyfe Keto?
A: BioLyfe Keto is made with all-natural ingredients and is generally considered safe for most users. However, as with any supplement, it is important to consult with your healthcare provider before beginning a new weight loss regimen. Some users may experience mild side effects such as digestive issues or headaches, but these are typically temporary and subside with continued use.
Q: How does BioLyfe Keto promote weight loss?
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How To BUILD Glutes While LOSING A LOT OF WEIGHT (You DON’T need to bulk for muscle) “I am the highest weight I’ve ever been. I have the highest amount of fat on my body that I’ve had. Although I am big all over, my glutes are pretty flat right now. How can I BUILD my glutes while getting to a healthy weight?”. In many people's minds, losing a significant amount of body fat involves starving yourself and doing tons of cardio but this isn’t the most optimal way to do things. Although it is difficult to build muscle in a calorie deficit, it can be done and is worth the effort because it will help you lose more fat anyways. As you lose the fat, the muscle you've built will be revealed. In this video, we're going over my top tips for building glutes when you have a lot of weight to lose. ▶︎REFERENCED/RELATED VIDEOS: ✅Video The Question Is From (HOW TO MAINTAIN GLUTES WHILE LOSING WEIGHT): https://youtu.be/QjKTkUBGAn8 ✅How To Calculate Calorie Deficit For Fat Loss (WITHOUT Undereating) - 3 Methods https://youtu.be/FKaJ68vv4b8 ✅5 Ways To Maintain Glutes While Losing Weight (AT HOME FRIENDLY🏠) https://youtu.be/PBS9g2AYDY4 🔁 Lose Fat- Keep the Glutes PLAYLIST: https://youtube.com/playlist?list=PLKXtjN7Re92Vp2a6RxV7knz2sNzCDoqO9 ___________________________ Follow me!! 🎉 SUBSCRIBE: https://www.youtube.com/lauragfit?sub_confirmation=1 🙆🏼♀️ Instagram: @Lauragfit 💪Training and Nutrition Programs: https://www.lauramichellefitness.com (subscribe to my email list for freebies!!!) 👤 Facebook: https://www.facebook.com/lauragfit 📩 Email: [email protected]
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Adrian's Fat Loss System ➜ https://bit.ly/__CLICK__HERE ➜ Lose 30 Pounds (𝗼𝗳 𝗕𝗲𝗹𝗹𝘆 𝗙𝗮𝘁) EVERY 30 Days . . "Adrian, I 𝗟𝗼𝘀𝘁 𝟮𝟮 𝗣𝗼𝘂𝗻𝗱𝘀 𝗶𝗻 𝟮𝟯 𝗗𝗮𝘆𝘀. Why Haven't I Lost 30 By Now!?" -𝙽𝚊𝚘𝚖𝚒 𝚆𝚒𝚕𝚎𝚢 ➜ https://bit.ly/__CLICK__HERE ➜ Adrian's Fat Loss System . . Here’s more STATIONARY BIKE WORKOUTS to Lose Weight, 10 Minute BEGINNER https://www.youtube.com/watch?v=MOIhG2GbZ3c 30 Minute BEGINNER https://www.youtube.com/watch?v=G8cvg2i2r48 40 Minute INTERMEDIATE Level 1 https://www.youtube.com/watch?v=06EmQ0qqW0I 30 Minute INTERMEDIATE Level 2 https://www.youtube.com/watch?v=_m_xW0patsk 60 Minute ADVANCED https://www.youtube.com/watch?v=rY8oEc9WqK4 30 Minute EXTREME 👈 0:00 YOU JUST DID THIS ONE RECUMBENT BIKE Workout for ABSOLUTE BEGINNERS https://www.youtube.com/watch?v=0tlNyrdMfn4 Use the Bike’s MANUAL or QUICKSTART program. Pedal AS FAST AS POSSIBLE (without adjusting the tension) to BURN FAT as fast as possible. SORRY, the Gold's Gym 290 C Stationary Exercise Bike used by @AdrianBryant in the workout video is no longer available but... Any stationary bike like https://amzn.to/3CB7hh1 is good for weight loss. Adrian’s Elliptical Weight Loss Workouts https://www.youtube.com/playlist?list=PL5qWKDYV54nGTA04wnMmZ2VvhOQFGUrC- https://www.youtube.com/watch?v=2M1BabvgEHE to see the weight loss results people got from doing @AdrianBryant workouts DISCLAIMER: The information provided by Adrian Bryant is of a general nature and is furnished only for educational/entertainment purposes only. No information is to be taken as medical or other health advice pertaining to any individual specific health or medical condition. Consult your physician before starting any exercise or workout program. You agree that use of this information is at your own risk and hold Adrian Bryant harmless from any and all losses, liabilities, injuries or damages resulting from any and all claims.
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Apple Cider Vinegar Gummies have become a popular health trend in recent years, and one company that has been gaining attention is the one featured on Shark Tank. These gummies are made from apple cider vinegar, a common household ingredient known for its potential health benefits. The idea of turning this tart liquid into a tasty gummy form has piqued the interest of many health-conscious consumers looking for an easy way to incorporate apple cider vinegar into their daily routine.
The Journey of Apple Cider Vinegar Gummies on Shark Tank
On an episode of Shark Tank, a company that specializes in Apple Cider Vinegar Gummies caught the attention of the sharks. The entrepreneurs behind the product pitched their idea of creating a more palatable version of apple cider vinegar that could appeal to a wider audience. The sharks were intrigued by the unique concept and the potential health benefits of the gummies, leading to a successful deal that would help bring this product to market.
The Apple Cider Vinegar Gummies showcased on Shark Tank are made from high-quality ingredients, including apple cider vinegar, pectin, and natural flavors. These gummies are a convenient and tasty way to get the benefits of apple cider vinegar without the strong taste and smell that can be off-putting to some people. Each gummy is packed with antioxidants, vitamins, and minerals that can support overall health and well-being.
Benefits of Apple Cider Vinegar Gummies
One of the main benefits of Apple Cider Vinegar Gummies is their potential to support digestive health. Apple cider vinegar has been traditionally used as a natural remedy for digestive issues, such as bloating, gas, and indigestion. The gummies can help promote better digestion and gut health, thanks to the beneficial bacteria found in apple cider vinegar.
In addition to digestive health, Apple Cider Vinegar Gummies may also help support weight management. Apple cider vinegar has been shown to help regulate blood sugar levels and reduce cravings, which can aid in weight loss efforts. By incorporating these gummies into a healthy diet and exercise routine, individuals may experience enhanced weight loss results.
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When it comes to incorporating Apple Cider Vinegar Gummies into your daily routine, there are several ways to enjoy the benefits of this popular health supplement. You can simply chew one or two gummies each day, either on their own or as part of a meal. The gummies can be a great addition to your morning routine or taken as a midday snack to help support your overall health and wellness.
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