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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Max Keto Gummies are a convenient and tasty way to stay on track with your ketogenic diet. These gummies are made with high-quality ingredients that are low in carbs and sugar, making them the perfect snack or treat for anyone following a keto lifestyle. Each gummy is packed with essential nutrients and antioxidants to help support your overall health and well-being while keeping you in ketosis.

With Max Keto Gummies, you can enjoy the benefits of ketosis without sacrificing your favorite gummy treats. These gummies are specifically designed to help boost your energy levels, promote fat burning, and support mental clarity. Whether you are looking to lose weight, improve your athletic performance, or simply feel better overall, Max Keto Gummies are a delicious and convenient way to support your ketogenic lifestyle.

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One of the best things about Max Keto Gummies is the wide variety of delicious flavor options available. From fruity favorites like raspberry and strawberry to more indulgent flavors like chocolate and caramel, there is a flavor for everyone to enjoy. Whether you prefer sweet or sour gummies, Max Keto Gummies have you covered with a delicious taste that will satisfy your cravings without derailing your keto diet.

Unlike traditional gummy candies that are loaded with sugar and artificial ingredients, Max Keto Gummies are made with natural flavors and sweeteners to provide a guilt-free treat that you can enjoy anytime. These gummies are also gluten-free and dairy-free, making them a perfect choice for anyone with dietary restrictions or food sensitivities. With Max Keto Gummies, you can indulge in your favorite treats without any of the guilt.

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Another great benefit of Max Keto Gummies is how easy they are to incorporate into your daily routine. Whether you need a quick snack on the go or a sweet treat after dinner, these gummies are a convenient and portable option that you can enjoy anytime, anywhere. Simply pop a few gummies in your bag or pocket, and you will have a delicious and satisfying treat ready whenever you need it.

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If you are looking to take your ketogenic diet to the next level and support your health and wellness goals, Max Keto Gummies are a must-have addition to your routine. These gummies are packed with essential nutrients and antioxidants to help keep you in ketosis and feeling your best. With their delicious flavor options and convenient packaging, Max Keto Gummies are the perfect choice for anyone following a keto lifestyle.

Whether you are new to the ketogenic diet or a long-time keto enthusiast, Max Keto Gummies are a tasty and convenient way to support your dietary goals and enjoy a guilt-free treat. Try Max Keto Gummies today and experience the benefits for yourself!

FAQs

1. Are Max Keto Gummies suitable for vegetarians?

Yes, Max Keto Gummies are suitable for vegetarians as they do not contain any animal-derived ingredients.

2. Can I take Max Keto Gummies if I have food allergies?

It is always recommended to check the ingredient list before consuming any product, especially if you have food allergies or sensitivities. Max Keto Gummies are gluten-free and dairy-free, but it is best to consult with your healthcare provider if you have specific concerns.

3. How many Max Keto Gummies can I consume per day?

The recommended serving size of Max Keto Gummies may vary, so it is best to follow the instructions on the packaging or consult with a healthcare professional for personalized advice.

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Max Keto Gummies are formulated for adults following a ketogenic diet. It is always best to consult with a pediatrician before giving any dietary supplements to children.

5. Where can I purchase Max Keto Gummies?

Max Keto Gummies are available for purchase online through various retailers and can also be found in select health food stores. Visit the official Max Keto website for more information on where to buy these delicious gummies.