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Metformin: Mechanism of action Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class. Still now it’s difficult to find a full explanation of the mechanism of action of metformin. However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK. Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production. Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent. There are other mechanisms also, like: It increases the insulin sensitivity Increases the fatty acid oxidation Decreases the intestinal glucose absorption Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.

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In this podcast, Dr. Mendonça summarizes the main findings from his study on "The Impact of Glucagon-like Peptide-1 Receptor Agonists on Kidney Outcomes: A Meta-Analysis of Randomized Placebo-Controlled Trials" on behalf of his colleagues.

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