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GLP-1, or glucagon-like peptide-1, plays a key role in glucose metabolism and appetite regulation in the body. The use of medications such as semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound), that mimic the action of GLP-1, have recently gained prominence in healthcare settings because of their success in the treatment of type 2 diabetes and the management of weight-loss. In this special extended Chemistry World webinar, you will have the chance to hear from three expert scientists working on GLP-1 science spanning the entire history of its development whilst also investigating its future applications for the management of a whole host of other diseases. Our three guests were: • Svetlana Mojsov, who is a pioneer in the study of this crucial hormone and whose research has been instrumental in the development of GLP-1 receptor agonists • Richard DiMarchi, whose academic expertise and work within the pharmaceutical industry has played a pivotal role in advancing both the scientific understanding and clinical application of GLP-1 therapies • Stefan Trapp, who leads a research group that investigates the physiological functions of GLP-1 and its potential as a therapeutic target for metabolic diseases

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Psychiatry Grand Rounds April 19, 2024 Glucagon-like peptide-1 (Glp1) receptor (Glp1r) agonists are drugs originally developed to treat type 2 diabetes but that are now also approved to treat obesity by promoting weight loss. This talk describes ongoing research in my lab focused on understanding the molecular mechanisms by which Glp1r agonists promote weight loss. Julio Ayala, PhD Associate Professor, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine https://www.vumc.org/psychiatry/grand-rounds/psychiatryGR_Ayala Objectives: The activity is designed to help the learner: 1. Describe background information about the biology and clinical use of Glucagon-like peptide-1 receptor (Glp1r) agonists. 2. Discuss the importance of pre-clinical investigations on the mechanism of action of Glp1r agonists. 3. Describe pre-clinical research conducted in the Ayala lab focusing on molecular mechanisms mediating the weight loss effect of Glp1r agonists. CME/CE credit for Psychiatry Grand Rounds is only available during the live feed time and for a brief time immediately following. The code for this week's session is displayed at the opening and closing of the meeting

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A video summary from the original blog "How to Determine the Maximum Dose of Ozempic for Weight Loss" published here: https://bmidoctors.com/how-to-determine-the-maximum-dose-of-ozempic-for-weight-loss/

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