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Welcome to The Chemist Couple podcast! With GLP-1 medications like Mounjaro becoming more popular, are we overlooking the risks? From potential nutrient deficiencies to serious health concerns like pancreatitis and diabetic retinopathy, we break it all down. Don't let the hype overshadow the science! ⚠️ ⏱️ Timestamps: * 00:00 - The Rise of GLP-1s: Why Are They So Popular? * 01:56 - Eating Less = Harm? The Hidden Risks * 03:43 - Losing Lean Mass: What You Need to Know * 04:55 - The Risk of Vitamin Deficiencies * 05:58 - Can You Keep the Weight Off? Leptin Explained * 07:51 - Lifestyle Changes: Key to Long-Term Success * 10:18 - The ‘Golden Dose’: A Dangerous Shortcut? * 11:57 - ‘Microdosing’ GLP-1s: Risky & Unlicensed! * 14:31 - Surgery & Aspiration: A New GLP-1 Warning * 18:36 - Just How Powerful Are GLP-1s? * 19:32 - Diabetic Retinopathy: An Overlooked Side Effect * 22:05 - Pancreatitis: A Rare but Serious Risk * 23:55 - Fertility, Pregnancy & Breastfeeding: What’s Safe? * 29:20 - Planning a Pregnancy? Here’s What to Consider * 30:21 - Final Thoughts: Are GLP-1s Worth the Risk? 🔔 Subscribe to The Chemist Couple Podcast: Stay on top of the latest science-based preventative health tips. Hit the like button and tell us: What are your thoughts on GLP-1 medication? 🎙️ Listen to our podcast: Spotify 🎧: The Chemist Couple PodcastApple Podcasts 🍏: The Chemist Couple Podcast 📩 Sign up for our newsletter to learn how we personally apply science to enhance our lifestyle: Join Here 📺 Watch this episode on YouTube: The Chemist Couple Podcast 📚 Studies Referenced in This Episode: * Guyton & Hall Medical Physiology (14th Edition) – General physiology overview * Rang & Dale’s Pharmacology (10th Edition) – General pharmacological overview * Electronic Medicines Compendium (EMC): Mounjaro (tirzepatide) Summary of Product Characteristics – Read Here * Diabetes & Primary Care, Vol 23 No 4 (2021): GLP-1 receptor agonists and diabetic retinopathy – Read Here ⚠️ Disclaimer: This podcast is for informational purposes only and should not replace advice from a healthcare professional. If you have any questions, reach out to us. Thanks for watching!
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Semaglutide is a medication that has been gaining attention in recent years for its effectiveness in promoting weight loss. Originally used to treat type 2 diabetes, semaglutide has now been approved for use in higher doses specifically for weight loss in individuals with obesity. Understanding the maximum dose of semaglutide is key to achieving optimal weight loss results while also managing any potential side effects that may arise.
The Science Behind Semaglutide
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of the hormone GLP-1. GLP-1 helps regulate blood sugar levels by stimulating insulin secretion, suppressing glucagon secretion, slowing down gastric emptying, and reducing appetite. By activating GLP-1 receptors in the brain, semaglutide can help people feel full sooner and consume fewer calories, leading to weight loss.
Studies have shown that semaglutide can lead to significant weight loss when used at higher doses compared to lower doses typically used for diabetes management. In fact, some clinical trials have demonstrated weight loss of up to 15% of initial body weight in participants taking semaglutide for weight management. This makes semaglutide a promising option for individuals struggling with obesity who have not had success with other weight loss methods.
In addition to promoting weight loss, semaglutide has also been shown to have other beneficial effects on health. For example, it can improve glycemic control, reduce blood pressure, and decrease the risk of cardiovascular events in individuals with obesity and type 2 diabetes. These additional health benefits make semaglutide a valuable treatment option for individuals with obesity and related comorbidities.
Understanding the Maximum Dose
The maximum dose of semaglutide for weight loss is typically 2.4 mg once weekly. This higher dose has been shown to be more effective at promoting weight loss compared to lower doses. However, it is important to note that the maximum dose of semaglutide may not be suitable for everyone. Individuals with certain medical conditions or risk factors may need to start at a lower dose and gradually increase to the maximum dose under the guidance of a healthcare provider.
It is also important to follow the prescribed dosing schedule for semaglutide to maximize its effectiveness. Missing doses or using the medication inconsistently can impact the results of treatment. Additionally, it is essential to adhere to a healthy diet and regular exercise routine while taking semaglutide to optimize weight loss outcomes.
Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild to moderate in severity and tend to improve over time as the body adjusts to the medication. However, if side effects persist or become bothersome, it is important to consult a healthcare provider for guidance on managing them.