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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]

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Working hard but not seeing results in frustrating, I get it! Make sure to also watch my video, Is Cortisol the Reason You're Not Losing Weight?? HERE: https://youtu.be/tV113qkJC4o How to join shaep: start your 7 day free trial https://join.shaep.co/browse Download your *free* breakfast recipe guide HERE: https://www.shaep.co/breakfast-recipe-guide/ Hi beauties! Are you losing weight but still not seeing the toned, strong body you’ve been working toward? In this video, we dive into why traditional weight-loss methods like endless cardio and calorie restriction might be holding you back from achieving your dream body. I’ll explain why focusing on the scale alone isn’t enough and share actionable strategies to help you build lean muscle, burn fat, and transform your body composition. From the importance of resistance training and eating enough protein to understanding recovery and progressive overload, this video covers everything you need to know to break free from the 'skinny fat' cycle and finally create the sculpted, confident physique you’ve been dreaming of. If you’re ready to stop chasing weight loss and start chasing strength, this video is for you! With love, Kelsey ✨LINKS✨ Yellow activewear set (ON SALE!): https://shorturl.at/HJkJe Walking pad: https://shorturl.at/wuM71 (30% off with my link!) Workout equipment: https://shorturl.at/dydLe Supplements: https://shorturl.at/ipNkD Protein powder & collagen: https://shorturl.at/One1M Shaep platform: https://join.shaep.co/ Follow me! Instagram: @thekelseyrose_ (https://shorturl.at/nh6Vo) TikTok: @thekelseyrose_ (https://shorturl.at/yzE68) Subscribe!!! (https://shorturl.at/9j2F0)

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How do you get the most out of your cardio workout if your goal is to burn fat? Answer: Start performing cardio workouts that keep your heart rate at about 65-70 percent of your MAX Heart rate. An approximate MAX Heart rate is 220-Your Age. For example, my MAX heart rate would be 220-60 = 160. Therefore, my ideal heart rate for burning fat while performing cardio would be 104-112 beats per minute. How do I achieve this type of heart rate? What cardio exercises would work best? Brisk Walking! Brisk walking is definitely my GO TO cardio exercise when I'm preparing for a bodybuilding show, like I'm currently doing. It burns fat, and maintains my muscle. Give this calculation a try on some of your upcoming cardio training. Let me know your thoughts. Leave me a comment in the comment section down below. I'd love to hear from you! Take control of your own health! Stay Young, Train Hard! Subscribe to our channel: https://bit.ly/2Qn6vMr Visit Our Website: ocramedhealth.com Join The Bring On 60 Facebook Group: https://www.facebook.com/groups/969357934844019 Order Our Resistance Bands Set https://ocramedhealth.com/products/resistance-bands-set Order The Arm Blaster For Bicep Growth https://ocramedhealth.com/products/arm-blaster Order Our Resistance Training Kit For Gymnasts https://ocramedhealth.com/products/resistance-training-kit Order Our Ab Roller https://ocramedhealth.com/products/ab-roller Order The Accommodation Avoidance System Home Workout Guide https://ocramedhealth.com/products/the-accommodation-avoidance-system Order your copy of Dr. Joe's Christmas book, A FITNESS CAROL https://ocramedhealth.com/products/a-fitness-carol-book DISCLAIMER: This content (the video, description, links, and comments) is not medical advice or a treatment plan and is intended for general education and demonstration purposes only. This content should not be used to self-diagnose or self-treat any health, medical, or physical condition. Don't use this content to avoid going to your own healthcare professional or to replace the advice they give you. Consult with your healthcare professional before doing anything contained in this content. You agree to indemnify and hold harmless OcraMed Health, Dr. Joe DeMarco, its officers, employees, and contractors for any and all losses, injuries, or damages resulting from any and all claims that arise from your use or misuse of this content. OcraMed Health/Dr. Joe DeMarco makes no representations about the accuracy or suitability of this content. Use of this content is at your sole risk. #cardio #fatburn #ocramedhealth #fitover50 #drjoedemarco

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Still stuck at the same weight despite all the effort? These 10 reasons might be secretly sabotaging your fat loss progress. Fix them and finally see results! Subscribe to SweatUp for more fitness and fat-loss tips. #FatLossTips #BurnFatFast #FitnessMistakes #WeightLossJourney #SweatUpShorts #CalorieDeficit #NoMoreExcuses #BodyTransformation #HealthyLiving #TrackYourMeals #FatLossMyths #StopFadDiets #FitnessTruth #HydrationMatters #SleepAndLoseWeight #WeekendCheatDay #NutritionAwareness #FitnessStruggles #SmartEating #MindfulFitness

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Why should you have a Liver shrinking diet before weightloss surgery, more so if this is to be performed laproscopically? What happens to the liver after this diet? Watch this animation. For more information on pre-op diets before weightloss surgery please visit http://www.simplyweight.co.uk

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This video features a patient testimonial who used a #wegovy alternative, semaglutide to assist with weight loss losing over 70 pounds in less than 1 year. The patient happens to be the practice manager at Elevated Concierge Hydration and Wellness and husband to Dr. Salimah Jones, DNP, FNP-C who runs the medical #weightloss program. If you are struggling to lose weight this video offers inspiration and practical advice on how to get help. Get in touch with Elevated Concierge Hydration and Wellness echydrationandwellness.com instagram.com/echydrationandwellness Facebook.com/echydrationandwellness @echydrationandweightloss

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Good morning Final day about this Keto diet SWOC Analysiss. And in future I will change this talks about studies. Instead of 6 videos it will be done in one. Have a great day folks