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This Harvard Medical School Continuing Education video examines these key questions: When should GLP-1 receptor agonists be used for weight loss and in what dosage? What cautions should physicians be aware of when prescribing GLP-1 RA? Dr. Lee-Shing Chang, MD, an endocrinologist at Brigham and Women’s Hospital in Boston, Massachusetts, reviews the medical indications and side effects of GLP-1 receptor agonists when used for weight loss. Dosing and administration are discussed and contraindications including pregnancy, retinopathy, and hypoglycemia are highlighted. 00:00 | Introduction 00:38 | Indications and contraindications for liragutide and semaglutide in weight loss 03:56 | Administration and dosing of GLP-1 receptor agonists 06:15 | Gastrointestinal side effects of GLP-1 receptor agonists 07:41 | Future directions for GLP-1 receptor agonists This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. References: Muskiet MHA, Tonneijck L, Smits MM, et al. GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes. Nat Rev Nephrol. 2017;13(10):605-628. doi:10.1038/nrneph.2017.123 Pi-Sunyer X, Astrup A, Fujioka K, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. doi:10.1056/NEJMoa1411892 Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989. doi:10.1056/NEJMoa2032183 Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138-150. Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021;325(14):1414-1425. doi:10.1001/jama.2021.3224 Notice: At this time, the content in this video is not accredited.

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Have you been celebrating quick weight loss on the scale? Maybe you shouldn’t be… Why? Because with these extremes you’re going to so that you can see the pounds fly off quickly But there’s a problem that almost everybody overlooks. You’re not controlling for if you're burning fat and not muscle. You might be losing weight quickly but you could be sabotaging your results. It’s also why you feel like you have to starve yourself to get back down to your goal weight and the process just gets harder and harder. The truth is…your hard work, trying to do more, is actually hindering your progress. And no one wants to work hard not to see the results they deserve! That's why in this video we're going to cover 5 signs you're actually burning fat and not muscle! 00:00 Intro 01:00 Ditch the scale 03:27 Losing inches 04:37 Clothing fits better 05:20 Workout performance 06:40 Progress photos 07:56 Muscle growth Check out the 3 Step Recipe For Burning Fat - https://rsrecipe.com?sl=youtube

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