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http://www.DoctorsToTrust.com @doctorstotrust presents episode 2413 | DR BEN BIKMAN w/ Digital Social Hour: Sean Kelly GLP-1 receptor agonists… -GLP-1 hormone we all make from small intestine -stimulated by certain carbs, proteins, fats -also stimulated by yerba mate tea & allulose When high, GLP-1 inhibits glucagon [tries to push glucose up] -helps blood sugar come under control -induces a sense of satiety by really slowing down the intestines GLP-1 receptor agonists… When first used, it was at a low dose -primary effect at that time was to inhibit glucogan -so, used as anti-diabetic med to control blood sugar -noticed that those on drug for diabetes tended to eat less New GLP-1 drugs are simply higher doses -effect: 1. lowers blood sugar 2. really, really slows down intestines Example: eat lunch, food stays in stomach 4 to 5 hours, into and through intestines -with drug: food sits in stomach up to 24 hours -it putrieies in stomach; may freeze intestines Paper in NEJM: for every 10 pounds weight loss on these drugs: -6 pounds is fat loss, but: 4 pounds is lean mass LOST 40% of loss is from muscle & bone! Example: middle age woman, trouble making muscle & bone… overweight, to takes drug for 24 months… then drops off the drug Because Tired of Feeling Sick -result: all weight comes back immediately -returns to original weight In older adults: drug helps you lose 40% muscle mass & bone… -get off drug: fat mass returns Easily, but Not Muscle nor Bone |||||||||||||||||||||||||||||||| doctorstotrust.com benbikman.com insuliniq.com hlthcode.com digitalsocialhour podcast original video: https://youtu.be/5HSgBkCMlXo?si=8RRT9CfeCDajC0HM We so not use corruptible, epidemiological survey research as causal science. For each short/sharable video, the original Youtube links are provided above. None of this content is intended to be individual, personalized medical advice. We hope you find value for yourself in these videos & find them easy to share with loved ones! DISCLAIMER The DoctorsToTrust videos are for general informational purposes only and do not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

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