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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Sign up for updates about each new episode: https://info.insidetracker.com/longevitybydesign View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1 Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity.   The Impact of GLP-1 on Fertility Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences. “If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.” We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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Many wondered what had brought about this result for the pop sensation and television host. The 38-year-old American singer and television personality Kelly Clarkson has recently sparked curiosity among fans, as the ex-winner of American Idol (2002) reported an impressive weight loss since joining The Voice as a coach in 2018. Swarming social media, fans were intrigued by the singer’s dramatic look, hungry to know the secret behind the change. In interviews given since she became a mother in 2014, Clarkson admitted that she has struggled with her weight all her life, often feeling uncomfortable about her appearance. These recent changes and the differences in her look have come as a great inspiration to fans, who want to know what led to such a drastic change.

The Decision to Prioritize Health

The most important reason for Kelly Clarkson’s weight loss is her commitment to her health. She’s made that clear in interviews, often saying that she wants to feel better for herself physically and mentally, or even saying that she wants to feel better for her kids.

How has Kelly, a working mom who juggles multiple obligations and has had a tough start to her adult life, able to make it work? How did she force herself into developing healthy eating habits and adhering to an exercise regime? Using some boundaries and better-planning, Kelly has not only been able overcome unhealthy habits, but she has also lost all the weight.

But besides setting a healthy example for her own kids and a very loyal – passionate – following of fans, through her examples and her semi-private displays of vulnerability, she’s helped many women see that they are more powerful than they currently believe. LA’s hardcore beach-body culture is nothing to sneeze at. Kelly made herself publicly vulnerable throughout her journey, sharing how hard she found it to work out bloody new knees, and how frustrated and angry she felt. Similar to scoliosis and gastroparesis survivor Alice’s story, Kelly’s work for ThinSolutions has become exceedingly more graduate school: she’s redefined herself so radically in the face of a debilitating disease that she’s found her own power. But these changes have also created some kind of self-other binary.

Embracing a Balanced Approach

Another thing that has been central to her weight-loss journey is an approach of balance. For Kelly, this has meant that she has invested in her mental and physical health – and in making changes that feel maintainable on a daily basis, not just in the short term or in extreme ways. Kelly wrote in one email: ‘I didn’t want to make extreme changes or deprive myself, but I knew that, if Tara didn’t place an emphasis on both the mental and physical side of losing weight, I would fail.’

Another part of Kelly’s balanced approach has been about working with experts – nurses, doctors and dieticians – to create a nutrition and workout plan that’s conducive to her individualistic needs and goals. As she learned new things about healthy eating, nutrition and fitness during her journey, Kelly entered the mind frame of someone who is actually educated about the techniques she’s using, rather than someone who just accepts a diet ‘because it works’. Kelly had the experts on her side to lean on and turn to when things got tough, giving her the resources she needed to succeed. We all can fall into a trap of depriving ourselves and over-effecting behaviors with visions of grapefruit-only futures, but in the long run, the support of a doctor or nutritionist can keep you on track and help you meet your goals.

Along with a strong emphasis on healthy but realistic food choices and regular exercise, Kelly has also focused on the importance of mental and emotional well-being when it comes to her weight loss. By being mindful, taking care of herself and practising stress management techniques, she has been able to break maladaptive habits of emotional overeating and negative body image. In this way, she has initiated the change from inside out, which gives her sustainable outcomes in her healthy intervention.

Staying Motivated and Consistent

Any weight loss journey inevitably involves some ebbs and flows and, for Kelly Clarkson, that’s meant that at times she’s struggled to stay inspired, accountable and motivated. An exercise she does, for instance, involves creating a gallery wall in her home filled with pictures of inspirational women who have motivated her during her weight loss. Her most recent post this summer shows an additional note to the gallery wall: ‘It’s not a journey that you go on and then come back from. It’s a life choice.’ For those of us who haven’t experienced stardom, or the pressure of having paparazzi follow us from the gym to our home, it’s much easier to stay dedicated to physical activity, finding support and, when needed, a dose of rejection, to push us to do more. This is one of the biggest challenges of weight management – maintaining the motivation and determination that gets you off your couch or out of bed and makes you move, week after week, month after month.

To keep going, Kelly has had to celebrate ‘micro-wins’ (or small, achievable goals that allow for occasional indulgences or treats) and maintain her long-term vision for ‘healthy vitality’. Rather than feeling overwhelmed by the vastness of her journey, she breaks things up into a series of milestones, checking off one metric at a time and enjoying the satisfaction of seeing her improvements add up. This helps prevent her getting bogged down in the present, keeping her future-oriented and incentivised to keep improving.

The ability to set a goal, stay on task and motivated, and develop consistency and healthy habits are all requirements to continued success. Kelly works on every one of these elements of permanent weight loss.

Conclusion

To summarise, Kelly Clarkson’s weight loss journey can be regarded as a testimony to how she, despite intense criticism and conspiratorial theories, has taken thoughtful control of her health and wellbeing and chose to do so with balance and without demonising certain types of food. Her journey has also shown how her pain could be understood and addressed at the emotional level. Her success may ultimately be a testament to how her intentional lifestyle choices, support from those around her and hard work, both physically and mentally, have led to a sustainable transformation that goes beyond body image. As she continues to empower herself through self-care, mindfulness and being her authentic self, it is no surprise that fans around the world cheer her on and celebrate every milestone of her ongoing fitness and wellbeing journey.

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Embarking on a Transformative Journey

Trisha Yearwood is not just a celebrated country music star; she is also an inspiring figure in the realm of health and wellness. Over the years, she has shared her culinary talents and vibrant personality with fans, but behind the scenes, Trisha has embarked on a profound journey of self-discovery and health that led to her remarkable 55-pound weight loss. This transformation reflects not merely a change in physical appearance, but a holistic shift that encompasses mental resilience, lifestyle alterations, and a deepened sense of self-love.

In the competitive landscape of the music industry, where image often plays a crucial role, Trisha’s journey stands out as a testament to personal determination and the commitment to one’s well-being. As a prominent figure in popular culture, her story resonates with many who are grappling with their own health challenges. Trisha has always been open about her struggles with weight and self-image, articulating her feelings and experiences in a way that many can relate to, thus establishing a connection with her audience.

Trisha has shown that the path to wellness is not a straight line but rather a winding road filled with lessons, setbacks, and triumphs. Her journey is a beacon of hope for those who may feel lost or discouraged in their pursuit of a healthier lifestyle. As she has stepped into the spotlight to discuss her health transformation, she has sparked conversations surrounding body positivity, mental health, and the importance of self-acceptance—key themes that are essential to the broader narrative of health and wellness. This article delves into the components of Trisha Yearwood’s journey, highlighting the pivotal moments and strategies that have driven her success.

Understanding the Motivation Behind Change

The first step in Trisha Yearwood’s transformative journey was identifying the motivation that drove her to pursue a healthier lifestyle. Like many others, she had been wrestling with societal pressures and expectations that influenced her self-image. The entertainment industry often emphasizes the importance of physical appearance, which can lead to negative self-perception and unhealthy habits. Trisha’s awakening came when she realized that the constant focus on weight and appearance was overshadowing her deeper personal goals, including health and emotional well-being.

Trisha’s decision to embark on a journey towards better health was rooted in the desire to live life fully and enjoy her passions, such as cooking and music, without the constraints of physical limitations. She wanted to be an active participant in her life, engaging in activities that brought her joy without feeling hindered by her weight. Her awakening empowered her to take ownership of her health and make intentional choices that would lead her toward a more fulfilling existence.

Moreover, Trisha’s motivation was not driven solely by external pressures but also by a fundamental desire for self-love. Through her journey, she discovered that prioritizing her health was an act of kindness towards herself. Learning to love her body, regardless of its shape or size, became a significant part of her evolution. This newfound perspective set the groundwork for her transformation, allowing her to approach weight loss not as a punishment but as an empowering experience.

Implementing Diet and Exercise Changes

Central to Trisha Yearwood’s weight loss journey was the commitment to making sustainable dietary and exercise changes. Rather than resorting to crash diets or extreme exercise regimens, Trisha focused on creating a balanced lifestyle that incorporated healthier food choices she could enjoy long-term. This strategy allowed her to embrace her love for cooking while also being mindful of her nutritional intake.

Trisha revamped her approach to cooking, emphasizing the importance of wholesome ingredients while still indulging in the comfort foods that she cherished. She shifted towards a diet rich in fruits, vegetables, lean proteins, and whole grains, while also making conscious efforts to reduce sugar and processed foods. This thoughtful reimagining of her culinary practices not only supported her weight loss goals but also fueled her passion for sharing healthful cooking with her audience through her cookbooks and television shows.

Equally important to her dietary changes was the incorporation of regular physical activity. Trisha recognized that exercise was not just a means to an end but a vital component of her overall happiness and mental well-being. She engaged in various forms of exercise that she enjoyed, such as walking, dancing, and strength training. By focusing on enjoying the process rather than viewing it purely as a chore, she found herself more committed to staying active, creating a sustainable routine that enhanced her physical and mental health.

Coping with Setbacks and Celebrating Successes

Trisha Yearwood’s journey was not without its challenges. Like many individuals striving to improve their health, she faced moments of doubt, setbacks, and temptations along the way. These hurdles served as important lessons that contributed to her resilience and determination. By acknowledging these difficulties, Trisha was able to navigate her path with grace rather than allowing temporary failures to discourage her.

During the journey, Trisha learned that nurturing a positive mindset was crucial for sustained progress. She cultivated strategies to cope with emotional eating and external pressures, reminding herself that setbacks were part of the process rather than indicators of failure. By focusing on the long-term benefits of her lifestyle changes rather than immediate results, she maintained a healthy perspective that empowered her to keep moving forward.

As Trisha experienced milestones in her weight loss journey, she made it a point to celebrate her accomplishments, big or small. Whether it was fitting into clothes that she loved or noticing increased stamina, she recognized the importance of acknowledging progress. These celebrations became a source of motivation, reinforcing her commitment to a lifestyle grounded in health and self-improvement.

Embracing the Journey of Self-Love

At the core of Trisha Yearwood’s transformation lies the profound journey of self-love. Though physical changes can be visually striking, Trisha has emphasized that the internal shifts have been equally, if not more, important. Through her weight loss journey, she fostered a greater appreciation for her body, understanding that it was a valuable vessel that deserved kindness and compassion. As she learned to embrace her imperfections, Trisha set an example for many who might be struggling with self-acceptance.

Trisha’s perspective on self-love extended beyond the reflection in the mirror. She acknowledged that loving oneself involves making choices that serve personal health and happiness. This realization was a pivotal factor in her weight loss journey, allowing her to approach dieting and exercise from a place of love rather than self-criticism. By putting her well-being first, she nurtured a positive relationship with her body, creating a powerful foundation for lasting change.

A significant aspect of this journey was also the connection she built with her fans. By sharing her experiences openly, Trisha not only inspired others but also created a supportive community where individuals could discuss their challenges and victories in health. In offering her story, she encouraged others to forgive themselves for past struggles and to prioritize their journeys toward self-love. As a result, Trisha Yearwood’s journey transcended her own transformation; it became a movement for acceptance and empowerment for many.

Defining Moments and Lasting Impact

Trisha Yearwood’s journey of weight loss and self-love has left a profound impact not only on her life but also on those of her fans and followers. One of the defining moments in her journey came when she recognized that her health was a lifelong endeavor, not just a phase. This realization shifted her perspective, allowing her to commit to long-lasting changes rather than short-term fixes. Trisha’s journey has encouraged many to adopt a healthier lifestyle by approaching their goals with patience and consistency.

The importance of sharing one’s journey cannot be overstated. By being transparent about her struggles and successes, Trisha has inspired countless individuals to confront their own health issues with courage. She has effectively cultivated a narrative that emphasizes the value of personal story-telling in the quest for health and well-being. This cultural shift in perception paves the way for greater tolerance and understanding regarding body image and individual struggles.

Moving forward, Trisha Yearwood continues to advocate for health and wellness through her platform, providing individuals with resources to support their journeys. Her cookbooks and television shows showcase a lifestyle that is attainable and enjoyable, proving that health does not have to compromise pleasure. With her unwavering commitment to empowering others, Trisha not only celebrates her personal journey but also uplifts countless individuals seeking to transform their lives.

Frequently Asked Questions

The narrative of Trisha Yearwood’s weight loss is not just one of physical transformation; it encompasses deeper themes of health, self-love, and empowerment. Many fans and individuals exploring their paths to wellness have questions about her approach. One common inquiry is how Trisha maintained her motivation throughout her journey. Trisha emphasizes the importance of setting realistic goals and surrounding oneself with supportive individuals. By creating an environment that fosters encouragement and positivity, she believes that individuals can cultivate greater resilience in their health journeys.

Another frequent question pertains to the specifics of her dietary changes. Trisha often shares that her focus was not on strict diets but rather on making healthier choices when cooking and dining. She places a strong emphasis on enjoying food while being mindful of ingredients. Through her cookbooks, she provides accessible recipes that celebrate flavors and nutrition, encouraging others to find joy in cooking healthful meals.

Lastly, many are curious about the role of mental health in Trisha’s transformation. She believes that mental well-being is intricately linked to physical health. Throughout her journey, she has employed various self-care strategies, including mindfulness, gratitude practices, and allowing herself grace during challenging times. Trisha advocates for a holistic approach to health, where mind, body, and spirit contribute to overall well-being. Through her story, she imparts valuable lessons about the significance of nurturing every facet of oneself in the pursuit of a healthier, happier life.

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