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Burn Fat Faster | How to Enter 'Fat-Burning Mode' Quicker (Pre-Fasting Strategy)
Study - American Journal of Physiology:
Assessed the impact of the macronutrient content of a meal on the postprandial leptin response. 22 young healthy subjects (11 men and 11 women) were given, in a randomized order, an isoenergetic meal [carbohydrate (81%) or fat (79%)] or remained fasting. In both genders, leptin response was higher after the carbohydrate meal than after the fat meal and while fasting. In conclusion, a carbohydrate meal induces higher postprandial leptin levels than an isoenergetic fat meal.
https://www.ncbi.nlm.nih.gov/pubmed/10567012
So we know that carbs will increase levels of leptin. However, the following study found that leptin levels need to be low in order for fat burning to take place. So trying to spike your leptin right before a fast could be counterproductive.
Leptin & Fat Burning:
To keep the human brain supplied with energy when food was scarce, mammals evolved the ability to switch from burning carbohydrates to burning fat in order to preserve skeletal muscle that would otherwise be metabolized and converted to glucose. Scientists long believed that the transition to fat metabolism was instigated solely by a drop in insulin. But a new study identified leptin as a key mediator - during starvation, plasma leptin levels fall, activating a pathway that promotes the breakdown of fat and mediates this critical shift from glucose to fat metabolism. While a drop in insulin also occurs, a decrease in leptin is also necessary for this process to happen.
Study Summation:
Researchers investigated the rate of carbohydrate and fat metabolism as rats went from a fed to a fasted state. The researchers observed that as the rats fasted, leptin levels decreased and activated a pathway that led to fat burning rather than carb burning. During fasting, the rats' use of stored glucose went down and sugar levels decreased as a result. In turn, levels of insulin and leptin decreased - the rats' bodies then broke down body fat to be turned into ketones for energy.
Study – Cell:
Researchers had rats fast for 48 hours - plasma non-esterified fatty acid (NEFA), glycerol, and bHB (β-OHB) concentrations increased progressively throughout the fast. Unsurprisingly, the reduction in plasma glucose concentrations that occurs as a fast progresses was accompanied by reductions in plasma insulin concentrations and increases in plasma glucagon concentrations. However, they also found that plasma leptin concentrations decreased by 80% between fed and 48-hr fasted rats. Next researchers specifically investigated the impact of reductions in net hepatic glycogenolysis on rates of endogenous glucose production, plasma leptin concentrations, and activation of the HPA axis. They treated post-absorptive rats fasted for 8, 16, and 48 hour with a small molecule inhibitor of glycogen phosphorylase, which resulted in reductions in plasma glucose and insulin concentrations. This was done as it’s consistent with the negligible contributions that hepatic glycogenolysis would be expected to have on plasma glucose concentrations in the glycogen-depleted state (during prolonged fasting.) Interestingly, the reductions in plasma glucose and insulin concentrations in fasted rats treated with the glycogen phosphorylase inhibitor were associated with reductions in plasma leptin concentrations and increases in HPA axis activity, as reflected by increases in plasma corticosterone and ACTH concentrations in these groups.
The researchers next infused rats fasted for 48 hours with leptin and found:
Increased leptin levels resulted in the suppression of plasma NEFA, glycerol, β-OHB, and lactate concentrations - suppressed HPA axis activity and plasma corticosterone levels as well.
Leptin & Fat Burning:
Leptin - corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (cortisol in humans) concentrations. Corticotrophin-releasing hormone is secreted by the paraventricular nucleus of the hypothalamus - Corticotrophin-releasing hormone is given this name because it causes release of adrenocorticotropic hormone from the pituitary gland. Adrenocorticotropic hormone, in turn, travels in the bloodstream to the adrenal glands, where it causes the secretion of the stress hormones.
Resources:
1) https://www.diabetes.co.uk/news/2018/jan/drop-in-both-insulin-and-leptin-needed-for-fat-burning-to-occur-90969878.html
2) https://www.cell.com/cell/fulltext/S0092-8674(17)31443-5
3) https://www.ncbi.nlm.nih.gov/pubmed/29307489
4) https://www.ncbi.nlm.nih.gov/pubmed/8717038/
5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430504/
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The Future of Oral GLP-1 Medications: A Game Changer in Obesity Treatment? In this episode, Christopher Durham discusses the emerging landscape of oral GLP-1 medications, featuring developments from leading pharmaceutical companies like Eli Lilly, Novo Nordisk, and Pfizer. He shares a personal journey of significant weight loss alongside his wife Laraine, thanks to GLP-1 medications. The episode dives into the potential of oral GLP-1s to revolutionize obesity treatment by offering needle-free, cost-effective options. Christopher highlights the current frontrunners in development and the broader implications for global obesity care, while also cautioning about the risks of unregulated compounded pills. DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction to Oral GLP-1 Medications 00:40 Meet the Downsized: Our Weight Loss Journey 03:21 Understanding Obesity: A Global Epidemic 04:11 The Financial and Policy Landscape of Obesity Treatment 05:28 The Promise of Oral GLP-1 Medications 06:16 Top Contenders in the Oral GLP-1 Race 11:43 Potential and Challenges of Oral GLP-1s 16:22 Conclusion and Future Outlook
Look Back And Be Proud Of Yourself Weightloss Transformation
Are you on a keto diet but miss indulging in delicious gummy candies? Look no further because we have the perfect solution for you – delicious keto gummies! These gummies are not only low in carbs and sugar but also taste amazing, so you can satisfy your sweet tooth while staying in ketosis. Say goodbye to feeling deprived of your favorite treats and hello to a tasty and guilt-free snack option that fits perfectly into your ketogenic lifestyle.
Benefits of Keto Gummies
One of the main benefits of keto gummies is that they provide a convenient way to snack without derailing your diet. Most traditional gummy candies are loaded with sugar and carbs, which can kick you out of ketosis and disrupt your progress. With keto gummies, you can enjoy a sweet treat without worrying about the negative impact on your body. Plus, these gummies are usually made with high-quality ingredients, such as gelatin, stevia, and natural flavors, so you can feel good about what you’re putting into your body.
Another benefit of keto gummies is their portability. Whether you’re on the go or just need a quick snack at home, keto gummies are easy to grab and enjoy anytime, anywhere. You can stash them in your purse, gym bag, or desk drawer for a convenient and satisfying snack that won’t sabotage your ketogenic goals. No more searching for keto-friendly options when you’re out and about – just pack some gummies and you’re good to go!
Additionally, keto gummies can help curb your cravings for sugary treats without sacrificing your progress. The combination of sweet flavors and chewy texture can satisfy your dessert cravings and keep you on track with your diet. Instead of reaching for high-carb candies or desserts, you can reach for keto gummies and indulge in a guilt-free treat that won’t disrupt your ketosis. It’s the perfect solution for anyone who wants to enjoy a sweet snack without compromising their health goals.
How to Make Keto Gummies
Making your own keto gummies at home is easier than you might think. All you need are a few simple ingredients and a silicone gummy mold to create your own delicious treats. Start by combining gelatin, water, and your choice of sweetener in a saucepan over low heat. Stir the mixture until the gelatin is fully dissolved and the sweetener is well incorporated.
Next, pour the mixture into the gummy mold and place it in the refrigerator to set for a few hours. Once the gummies are firm, pop them out of the mold and enjoy! You can customize your keto gummies with different flavors, colors, and even added nutrients like collagen or vitamin C. The possibilities are endless, so get creative and have fun making your own batch of keto gummies at home.
If you’re short on time or prefer a hassle-free option, you can also purchase pre-made keto gummies online or at your local health food store. These store-bought gummies are often made with high-quality ingredients and come in a variety of flavors to suit your preferences. Just make sure to check the nutrition label to ensure they fit within your keto macros and are free of any unwanted additives or artificial ingredients.
Incorporating Keto Gummies Into Your Diet
Once you have your delicious keto gummies in hand, you may be wondering how best to incorporate them into your ketogenic diet. The key is to enjoy them in moderation and as part of a balanced eating plan. While keto gummies are lower in carbs and sugar than traditional candies, they should still be consumed in moderation to avoid exceeding your daily carb limit.
You can enjoy keto gummies as a sweet treat after a meal, as a midday snack, or even as a pre-workout energy boost. Just be mindful of your portion sizes and track your intake to ensure you’re staying within your macros. Remember, the goal of the keto diet is to keep your body in a state of ketosis, so make sure your gummy consumption aligns with your overall dietary goals.
If you find yourself craving something sweet or reaching for unhealthy snacks, having a stash of keto gummies on hand can be a game-changer. Instead of giving in to temptation and derailing your progress, you can satisfy your cravings with a tasty and guilt-free option that won’t kick you out of ketosis. Plus, the convenience of keto gummies makes it easy to stay on track with your diet while still enjoying a delicious treat.
FAQs About Keto Gummies
Q: Are keto gummies suitable for everyone?
A: While keto gummies are generally safe for most people following a ketogenic diet, it’s always best to check with your healthcare provider before making any significant changes to your diet. If you have any underlying health conditions or specific dietary restrictions, it’s important to get personalized advice from a medical professional.
Q: Are store-bought keto gummies as healthy as homemade ones?
A: It depends on the brand and ingredients used in store-bought keto gummies. Some brands may use artificial sweeteners or additives that you may want to avoid. If you’re concerned about the quality of store-bought gummies, consider making your own at home using high-quality ingredients.
Q: Can I eat keto gummies every day?
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A: While it’s okay to enjoy keto gummies in moderation, it’s essential to balance your overall diet and not rely on gummies as your main source of nutrition. Be mindful of your carb intake and prioritize whole, nutrient-dense foods to support your health and well-being.
Q: How long do homemade keto gummies last?
A: Homemade keto gummies can last for up to two weeks when stored in an airtight container in the refrigerator. Make sure to check for any signs of spoilage before consuming them and discard any gummies that appear moldy or off in taste or texture.
Q: Can I freeze keto gummies for later use?
A: Yes, you can freeze keto gummies for future enjoyment. Simply place them in an airtight container or freezer bag and store them in the freezer for up to three months. When you’re ready to eat them, let the gummies thaw in the refrigerator or at room temperature before enjoying.