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The new class of GLP-1 weight loss drugs have been blockbusters since they arrived on the market a few years ago. These medications have made tens of billions of dollars for drugmakers and have made their way into the public consciousness in a remarkable way. Almost three-quarters of adults in the U.S. are overweight or obese, and obesity can lead to a litany of health complications, including heart disease, joint pain, and cancer. So there’s an enormous demand for highly effective weight loss drugs like Wegovy and Zepbound. Meeting that huge demand has been challenging. The name-brand medications are very expensive and not always covered by insurance. Even with coverage, consistent shortages of these drugs have plagued the market. But there is a loophole filling this market gap. When name-brand drugs are in shortage, the FDA temporarily allows compounding pharmacies to make generic versions of these medicines. These specialized pharmacies, which typically make customized drugs for individual patient needs, have become a popular alternative for patients seeking GLP-1 prescriptions. This has led to an explosion of telehealth companies offering compounded versions of GLP-1s like Ozempic at a much lower price than the brand-name products. This has meant big business for both telehealth companies and compounding pharmacies. But the future of this cottage industry, and the patients that have come to rely on the drugs they sell, is very much uncertain. In this deep-dive explainer video, STAT takes you through how exactly this alternative market for GLP-1s works. 00:00 Intro 00:55 Why is there so much demand for GLP-1s? 01:56 What is a compounding pharmacy? 02:34 Why compounding pharmacies can make "copies" of brand-name GLP1s 04:15 How telehealth companies prescribe GLP-1s 05:43 Things to keep in mind for people considering compounded GLP-1s 07:40 What does the future hold for patients taking compounded GLP-1s? More from STAT: Become a subscriber: https://www.statnews.com/stat-plus/ Watch Full Episodes: https://www.youtube.com/@Statnews Newsletters: https://www.statnews.com/signup/ STAT events: https://www.statnews.com/stat-events/ Facebook: https://www.facebook.com/statnews Twitter: https://twitter.com/statnews Instagram: https://www.instagram.com/statnews/ Flipboard: rb.gy/3xnsxr STAT Reports: https://rb.gy/rexfwj STAT eBooks: https://rb.gy/eme3h5 ABOUT STAT: Founded in 2015, STAT is a global digital media brand that focuses on delivering fast, deep, and tough-minded journalism about the life sciences industries to over six million monthly site visitors and an additional 20 million readers on the Apple News app. STAT takes you inside academic labs, biotech boardrooms, and political backrooms, casting a critical eye on scientific discoveries, scrutinizing corporate strategies, and chronicling the roiling battles for talent, money, and market share. With an award-winning newsroom, STAT provides indispensable insights and exclusive stories on the technologies, personalities, power brokers, and political forces driving massive changes in the life sciences industry — and a revolution in human health.

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Obesity has become a major health concern worldwide, with millions of people struggling to lose weight and improve their overall well-being. Many individuals have turned to medications like semaglutide to aid in their weight loss journey. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has shown promising results in helping individuals shed excess pounds. In this article, we will explore the effects of semaglutide before and after weight loss, diving into how this medication works, its potential benefits, and what individuals can expect when using it.

How Semaglutide Works

Semaglutide works by mimicking the effects of a hormone called GLP-1 that is naturally produced by the body. GLP-1 helps regulate blood sugar levels, increase feelings of fullness, and slow down digestion. By activating GLP-1 receptors in the body, semaglutide can help individuals eat less, feel satisfied with smaller portions, and ultimately lose weight. It also helps the pancreas release insulin in response to meals, which can improve blood sugar control in individuals with diabetes.

When taken as an injection once a week, semaglutide can help individuals achieve significant weight loss over time. Studies have shown that patients who took semaglutide lost more weight compared to those taking a placebo. Additionally, semaglutide has been shown to reduce the risk of developing obesity-related conditions such as type 2 diabetes and high blood pressure.

One of the reasons semaglutide is effective for weight loss is its impact on appetite regulation. By increasing feelings of fullness and reducing cravings, individuals may find it easier to adhere to a healthier diet and make better food choices. Semaglutide can also help improve metabolic health by reducing fat accumulation in the liver and promoting the use of stored fat for energy.

Potential Benefits of Semaglutide

In addition to weight loss, semaglutide has been associated with other health benefits that can improve overall well-being. For individuals with type 2 diabetes, semaglutide can help lower blood sugar levels and reduce the need for other medications to manage the condition. This can lead to better glycemic control and a decreased risk of diabetes-related complications.

Furthermore, semaglutide has been shown to improve cardiovascular health by reducing the risk of heart attacks, strokes, and other cardiovascular events. This is especially important for individuals with obesity, who are at a higher risk of developing heart disease and other cardiovascular conditions. By promoting weight loss and improving metabolic health, semaglutide can help individuals reduce their cardiovascular risk factors and live healthier lives.

Another potential benefit of semaglutide is its impact on overall quality of life. Losing weight and improving metabolic health can boost self-confidence, energy levels, and mood. Individuals may find that they have more motivation to engage in physical activity, socialize with others, and pursue their goals when they feel better physically and emotionally.

What to Expect When Using Semaglutide

Before starting semaglutide, individuals should consult with their healthcare provider to determine if this medication is suitable for them. It is important to discuss any underlying medical conditions, current medications, and weight loss goals to ensure that semaglutide is safe and effective. Healthcare providers can also provide guidance on how to inject semaglutide properly and monitor for any potential side effects.

When using semaglutide, individuals can expect to see gradual weight loss over time, with most studies showing significant results within a few months of starting treatment. It is important to follow a healthy diet, engage in regular physical activity, and make lifestyle changes to maximize the benefits of semaglutide. Some individuals may experience side effects such as nausea, vomiting, or diarrhea, but these symptoms typically improve over time as the body adjusts to the medication.

Overall, semaglutide can be a valuable tool for individuals looking to lose weight and improve their health. By working with healthcare providers, making lifestyle changes, and staying consistent with treatment, individuals can achieve meaningful results with semaglutide and enjoy a healthier, happier life.

Semaglutide may be a new player in the weight loss game, but its effectiveness has already been making waves. If you’ve been considering semaglutide as a solution for your weight loss goals, read on to find out more about how this medication can help you achieve the results you desire.

Below are some common questions and answers about semaglutide before and after weight loss:

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