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In this episode of the Pharm So Hard Podcast, the hosts discuss GLP-1 receptor agonists, a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. They provide an overview of the history and development of GLP-1 receptor agonists, highlighting their clinical superiority and various benefits. The hosts also explain the role of GLP-1s in the body, including their glucose-dependent insulin secretion and effects on gastric emptying. They discuss the impact of GLP-1s on hunger and mental health, emphasizing the reduction of food noise and improvement in satiety levels. Additionally, they differentiate GLP-1 receptor agonists for diabetes and weight loss and explore their indications and guideline positioning. Takeaways • GLP-1 receptor agonists are a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. • GLP-1 receptor agonists have shown clinical superiority to other anti-hyperglycemic drugs, improving glycemic control, reducing weight loss and blood pressure, and providing cardio-protective benefits. • GLP-1s increase glucose-dependent insulin secretion, block glucagon secretion, and slow gastric emptying, leading to improved blood sugar control and increased satiety. • GLP-1 receptor agonists have a positive impact on mental health, reducing food noise and helping individuals make healthier food choices. • Different GLP-1 receptor agonists have specific indications for diabetes and weight loss, and their use is guided by clinical guidelines. • GLP-1 receptor agonists are FDA-approved for improving glycemic control in patients with type 2 diabetes and for the treatment of obesity. • The choice of GLP-1 receptor agonist depends on factors such as comorbidities, weight loss goals, and patient preferences. • GLP-1 receptor agonists have different dosing regimens, and the specific dose may vary based on the indication and the product. • Common side effects of GLP-1 receptor agonists include nausea, vomiting, and diarrhea, but these side effects often improve with continued use and proper management. GLP-1 agonists can cause loss of appetite as a side effect. • GLP-1s are being used off-label for conditions such as NAFLD and depression. • GLP-1s may have positive effects on bone health and blood pressure. • The high cost of GLP-1s poses challenges for patient access. Chapters 00:00 Introduction to GLP-1 Receptor Agonists 01:12 History and Development of GLP-1 Receptor Agonists 06:14 The Role of GLP-1s in the Body 09:38 Effects of GLP-1s on Hunger and Mental Health 11:17 Differentiation of GLP-1 Receptor Agonists for Diabetes and Weight Loss 11:44 Indications and Guideline Positioning of GLP-1 Receptor Agonists

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#マンジャロ #リベルサス #glp1 今回は薬剤師カルダモンが、現在痩せ薬として注目されている糖尿病治療薬GLP-1(グルカゴン様ペプチド-1)受容体作動薬について解説させていただきます。 そもそも GLP-1は、糖尿病治療において注目されている重要なホルモンです。現在痩せ薬として注目を集めすぎて本当に糖尿病治療に必要な患者さんに薬が行き届いていない現状があります。 この動画を見て正しい知識を身につけ薬が適切に使用されることを願います💊 【カルダモン薬局のコンテンツ👇】 💊公式ホームページ(薬剤師カルダモンの日記) https://healthcare-pharmacy.com/ 💊instagram https://www.instagram.com/spice_pharm... 💊Twitter https://twitter.com/spice_pharmacy 【病院薬剤師カルダモンのプロフィール】 病院薬剤師/緩和ケア/抗がん剤治療/漢方をカジュアルに 健康寿命を伸ばすために今からできることを考えていき、病気になったときに医療従事者とともに体のことを考えられるセルフメディケーション力を身につけていきましょう!

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What is a realistic goal when it comes to weight loss? Did you know that setting realistic goals can help you stay motivated? Join Dr. Edelman and Dr. Pettus as they share their expert insights on their top 10 tips for managing diabetes in 2025. Whether you have Type 1 or Type 2 diabetes, these practical strategies—including realistic goal-setting for weight loss—will help you start the year right and maintain better health throughout 2025. What’s your approach to setting and tracking weight goals? Share in the comments! Watch the full video here: https://bit.ly/4fVM1Fq

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