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Metformin: Mechanism of action Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class. Still now it’s difficult to find a full explanation of the mechanism of action of metformin. However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK. Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production. Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent. There are other mechanisms also, like: It increases the insulin sensitivity Increases the fatty acid oxidation Decreases the intestinal glucose absorption Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.

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There are 3 main macronutrients ⬇️ Carbohydrates, proteins and fats. Cabs are the body’s primary source of energy. they are broken down into glucose aka “blood sugar” for fuel. Protein is primarily used for building and repairing tissues, although protein can also be an energy source if cab intake is low. Fats are highly concentrated sources of energy that provide more calories gram for gram than cabs or proteins. I suppose what is in question here is not whether you burn fat in the absence of carbs (because this is obvious) but: Does a ketogenic diet wherein you take more fat and less carbohydrate actually help your body get better at metabolizing (“burning”) fat? The answer remains a tautological yes. Necessarily. A diet wherein you take fat and cut out carbs will help the body become more efficient at metabolizing fat because it forces the body to rely on fat as its primary fuel source instead of carbohydrates. Furthermore: - Some studies suggest certain healthy fats, like those found in olive oil, fish and nuts can help increase metabolic rate and burn more calories. It’s also worth remembering if weightloss is the goal, healthy fat can help you feel more full and satiated so you don’t overeat in the same way you might when it comes to carbs. *All fitness programs & recipes available for 50% off: The Sober Fitness Bundle 📚 #soberfitness #sober #fitness #recovery #health #diet #wellness #mentalhealth #happy #fitnessdailies #dailies #Workout #12step #onedayatatime #gingertea #mealprep #detox #prayer #meditation #motivation

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