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GLP-1 (Glucagon-Like Peptide-1) is a type of incretin hormone that plays a significant role in glucose metabolism and appetite regulation. GLP-1 compounds, including medications like liraglutide (Saxenda, Victoza) and semaglutide (Ozempic, Wegovy), are used primarily in the treatment of type 2 diabetes and obesity.
Key Functions:
Blood Sugar Control: GLP-1 enhances insulin secretion in response to meals, helping lower blood sugar levels.
Appetite Regulation: These compounds can help reduce appetite and promote weight loss by affecting the brain's appetite centers.
Cardiovascular Benefits: Some GLP-1 agonists have been shown to have positive effects on heart health.
Mechanism of Action:
GLP-1 compounds mimic the action of the natural GLP-1 hormone, leading to increased insulin secretion, decreased glucagon secretion, and slowed gastric emptying.
Uses:
Weight Management: They are effective for individuals with obesity or those seeking weight loss.
Diabetes Management: Prescribed for patients with type 2 diabetes who seek improved glycemic control.
Side Effects:
Common side effects may include nausea, vomiting, diarrhea, and risk of pancreatitis.
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