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Obesity specialist Dr Holly Lofton reveals how she chooses the right GLP-1 for each patient, and the importance of staying on label. https://www.medscape.com/viewarticle/1000524?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. With all the excitement about GLP-1 agonists, I get many questions from providers about which antiobesity drug they should prescribe. I'll tell you the methods that I use to determine which drug is best for which patient. Of course, we want to make sure that we're treating the right condition. If the patient has type 2 diabetes, we tend to give them medication that is indicated for type 2 diabetes. Many GLP-1 agonists are available in a diabetes version and a chronic weight management or obesity version. If a patient has diabetes and obesity, they can receive either one. If a patient has only diabetes but not obesity, they should be prescribed the diabetes version. For obesity without diabetes, we tend to stick with the drugs that are indicated for chronic weight management. Let's go through them. Exenatide. In chronological order of approval, the first GLP-1 drug that was used for diabetes dates back to exenatide (Bydureon). Bydureon had a partner called Byetta (also exenatide), both of which are still on the market but infrequently used. Some patients reported that these medications were inconvenient because they required twice-daily injections and caused painful injection-site nodules. Diabetes drugs in more common use include liraglutide (Victoza) for type 2 diabetes. It is a daily injection and has various doses. We always start low and increase with tolerance and desired effect for A1c. Liraglutide. Victoza has an antiobesity counterpart called Saxenda. The Saxenda pen looks very similar to the Victoza pen. It is a daily GLP-1 agonist for chronic weight management. The SCALE trial demonstrated 8%-12% weight loss with Saxenda. Those are the daily injections: Victoza for diabetes and Saxenda for weight loss. Our patients are very excited about the advent of weekly injections for diabetes and weight management. Ozempic is very popular. It is a weekly GLP-1 agonist for type 2 diabetes. Many patients come in asking for Ozempic, and we must make sure that we're moving them in the right direction depending on their condition. Semaglutide. Ozempic has a few different doses. It is a weekly injection and has been found to be quite efficacious for treating diabetes. The drug's weight loss counterpart is called Wegovy, which comes in a different pen. Both forms contain the compound semaglutide. While all of these GLP-1 agonists are indicated to treat type 2 diabetes or for weight management, Wegovy has a special indication that none of the others have. In March 2024, Wegovy acquired an indication to decrease cardiac risk in those with a BMI ≥ 27 and a previous cardiac history. This will really change the accessibility of this medication because patients with heart conditions who are on Medicare are expected to have access to Wegovy. Tirzepatide. Another weekly injection for treatment of type 2 diabetes is called Mounjaro. Its counterpart for weight management is called Zepbound, which was found to have about 20.9% weight loss over 72 weeks. These medications have similar side effects in differing degrees, but the most-often reported are nausea, stool changes, abdominal pain, and reflux. There are some other potential side effects; I recommend that you read the individual prescribing information available for each drug to have more clarity about that. It is important that we stay on label for using the GLP-1 receptor agonists, for many reasons. One, it increases our patients' accessibility to the right medication for them, and we can also make sure that we're treating the patient with the right drug according to the clinical trials. When the clinical trials are done, the study populations demonstrate safety and efficacy for that population. But if we're prescribing a GLP-1 for a different population, it is considered off-label use. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000524?src=soc_yt
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ACV Keto Gummies are a convenient and delicious way to incorporate apple cider vinegar and the ketogenic diet into your daily routine. These gummies are typically made with a blend of ingredients that support ketosis, such as exogenous ketones and MCT oil, along with the added benefits of apple cider vinegar. By combining these ingredients, ACV Keto Gummies can help boost your metabolism, increase energy levels, and support weight loss efforts.
One of the main benefits of ACV Keto Gummies is their convenience. Instead of having to mix up a drink or swallow pills, you can simply pop a few gummies in your mouth and be on your way. This makes them a great option for busy individuals who want to prioritize their health without adding extra steps to their daily routine.
Additionally, ACV Keto Gummies are a tasty alternative to traditional apple cider vinegar supplements, which can have a strong and unpleasant taste. The gummies are typically flavored with natural ingredients like berries or citrus fruits, making them more palatable and enjoyable to consume.
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When shopping for ACV Keto Gummies, it’s important to do your research and choose a high-quality product that will give you the best results. Here are a few key factors to consider when selecting ACV Keto Gummies:
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Oprah Winfrey is undoubtedly one of the most influential figures in the entertainment industry. Over the years, she has captured the hearts of millions around the world with her iconic talk show, philanthropic efforts, and overall inspiring journey to success. However, like many of us, Oprah has also struggled with her weight and body image. In recent years, she has been open about her struggles with emotional eating and yo-yo dieting, leading to fluctuations in her weight. Despite these challenges, Oprah has managed to achieve significant weight loss and overall better health through the ketogenic diet, popularly known as the Keto diet.
Oprah Winfrey’s Journey to Keto
Oprah Winfrey’s weight loss journey has been well-documented over the years. She has openly shared her struggles with weight and body image, often attributing her issues to emotional eating and a lack of self-control. In 2016, Oprah invested in Weight Watchers, a popular weight loss program, and became a spokesperson for the brand. While she initially saw success with the program, she struggled to maintain her weight loss and found herself yo-yo dieting.
It wasn’t until Oprah discovered the ketogenic diet that she finally found a sustainable solution to her weight loss struggles. The Keto diet is a high-fat, low-carbohydrate eating plan that forces the body into a state of ketosis, where it burns fat for fuel instead of carbohydrates. By following the Keto diet, Oprah was able to regulate her blood sugar levels, reduce cravings, and ultimately achieve significant weight loss.
Under the guidance of her personal trainer, Bob Greene, and nutritionist, Dr. Oz, Oprah embarked on her Keto journey with determination and discipline. She embraced whole, nutrient-dense foods like avocados, nuts, seeds, and leafy greens while eliminating processed foods, sugars, and grains from her diet. Additionally, Oprah practiced intermittent fasting, further enhancing the benefits of the Keto diet and accelerating her weight loss results.
The Benefits of the Keto Diet for Oprah Winfrey
Through her commitment to the Keto diet, Oprah Winfrey has experienced a wide range of benefits beyond just weight loss. One of the most significant advantages of the Keto diet for Oprah has been improved mental clarity and focus. By fueling her body with healthy fats and reducing her intake of carbohydrates, Oprah has reported feeling more alert, energized, and productive throughout the day.
Furthermore, the Keto diet has helped Oprah regulate her hunger hormones, leading to reduced cravings and a more stable appetite. This has allowed her to make better food choices and maintain portion control, ultimately supporting her weight loss goals. Additionally, by following a high-fat, low-carb diet, Oprah has experienced improved cholesterol levels, reduced inflammation, and better overall heart health.
One of the most remarkable transformations that Oprah has undergone through the Keto diet is an increase in her self-confidence and body positivity. By taking control of her eating habits and prioritizing her health and well-being, Oprah has not only achieved significant weight loss but has also gained a newfound sense of empowerment and self-love.
Frequently Asked Questions about Oprah’s Keto Weight Loss
Q: How much weight has Oprah Winfrey lost on the Keto diet?
A: While Oprah Winfrey has not publicly disclosed the exact amount of weight she has lost on the Keto diet, she has visibly slimmed down and appears healthier and more vibrant than ever.
Q: Is the Keto diet safe for everyone to try?
A: Before starting any new diet or lifestyle change, it is essential to consult with a healthcare professional or nutritionist to ensure that the Keto diet is suitable for your individual needs and goals.
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Q: What are some tips for success on the Keto diet?
A: To maximize your results on the Keto diet, focus on consuming whole, nutrient-dense foods, staying hydrated, getting regular exercise, and listening to your body’s hunger and satiety cues. Additionally, be patient with yourself and stay consistent with your efforts to see lasting results.
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As famosas canetas emagrecedoras atuam no corpo de forma semelhante ao GLP-1, o hormônio da saciedade. Mas qual dessas opções é melhor para quem está buscando perder peso? Te conto no vídeo de hoje!
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