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“It's simple. It's painless, and it was a miracle. In three weeks I lost 18 pounds, and by three months, I had lost 38 pounds..." For several years Ozempic has been on the market to treat type 2 diabetes. It improves the way the body handles excesses of the hormone insulin. A side effect was that patients lost 15 percent of their body weight. So last year, in June of 2021, it was reformulated and approved for weight loss for patients, who are not diabetics, under the name Wegovy. “This drug is not a stimulant. It simply makes you feel full. We know that it affects your brain. It mimics a hormone that affects the satiety centers in your brain,” explained Bariatric Surgeon Dr. Matthew French. Dr. French of Surgical Specialists of Louisiana, says about 20 of the clinic's patients have used Wegovy. “And they say they just don't get hungry. They don't want the food. They don’t have the craving. And that's a powerful tool for losing weight,” explained Dr. French. “And I wasn't hungry, which was great. The best thing about this drug is it made alcohol taste horrible,” said Hare who noted she packed on part of her weight from the sugary calories in beer and wine. But after six months, Ramsey is no longer on Wegovy. Her cost-saving coupon ran out. Most Louisiana insurance companies don't pay for weight-loss medication like hers. Despite the long-term cost savings when people maintain ideal weight, companies don't include it in their coverage. The other problem is the drug is in high demand and can be difficult to get.

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Burn 500 calories a day, lose a pound a week? Sounds simple, right? Unfortunately, that’s not how human metabolism works. Your body is incredibly adaptive, and over time, it adjusts how many calories you burn. In today’s Perform with Dr. Andy Galpin episode, Dr. Herman Pontzer explains that while you might see an initial drop in weight, your body compensates by slowing down other energy expenditures, so you’re likely burning far fewer extra calories than you think—sometimes just half, sometimes even the same as before. And to be clear, this isn’t about inaccurate calorie burn estimates. We’re talking about real, internal physiological changes your body makes in response to increased energy use. On top of that, not eating the calories you burn is tough. The body naturally drives you to replace that energy, making sustainability the real challenge. So, if you’re not losing weight despite increasing exercise, don’t assume something is ‘broken’—your body is simply adapting, and you may need to adjust your approach. Smart training, sustainable nutrition, and understanding energy balance are key.

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When it comes to weight loss, there are various medications and treatments available in the market. Two popular options for weight loss are Ozempic and Semaglutide. Both medications are injectable glucagon-like peptide-1 receptor agonists that have been approved by the FDA for the treatment of obesity. While they belong to the same class of drugs, there are differences in their effectiveness and usage. In this article, we will compare the effectiveness of Ozempic vs Semaglutide for weight loss.

Ozempic

Ozempic, also known as semaglutide, is a once-weekly injectable medication that is used to improve blood sugar levels in adults with type 2 diabetes. It works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels and reduce appetite. In addition to its benefits for diabetes management, Ozempic has also been found to be effective for weight loss in clinical trials.

One of the key benefits of Ozempic is its ability to suppress appetite and reduce food intake. This can lead to a decrease in calorie consumption, which is essential for weight loss. In clinical studies, Ozempic has been shown to help patients lose significant amounts of weight when used in conjunction with a healthy diet and exercise routine. Some patients may experience mild side effects such as nausea or diarrhea, but these symptoms usually subside over time.

Another advantage of Ozempic is its convenience. Since it is a once-weekly injection, patients do not have to worry about taking multiple doses throughout the day. This can make it easier for individuals to adhere to their weight loss plan and stay on track with their treatment. Additionally, Ozempic has been found to have a positive impact on cardiovascular health, reducing the risk of heart disease and stroke in patients with type 2 diabetes.

Semaglutide

Semaglutide, on the other hand, is a daily injectable medication that is used to treat type 2 diabetes and obesity. It works in a similar way to Ozempic by increasing the levels of GLP-1 in the body, which can help control blood sugar levels and reduce appetite. Semaglutide has been shown to be effective for weight loss in clinical trials and is often prescribed off-label for this purpose.

One of the main advantages of Semaglutide is its potent effect on weight loss. In studies, Semaglutide has been found to help patients lose more weight compared to other weight loss medications. This can be particularly beneficial for individuals who have struggled to lose weight with diet and exercise alone. However, Semaglutide may cause more gastrointestinal side effects compared to Ozempic, such as nausea, vomiting, or constipation.

Another benefit of Semaglutide is its flexibility in dosing. Since it is a daily injection, patients can adjust their dose based on their individual needs and preferences. This can be helpful for individuals who may need more or less medication to achieve their weight loss goals. Additionally, Semaglutide has also been shown to have a positive impact on cardiovascular health, reducing the risk of heart disease and stroke in patients with obesity.

Comparison

When comparing Ozempic vs Semaglutide for weight loss, both medications have been found to be effective in helping patients lose weight when used in conjunction with a healthy diet and exercise routine. However, there are some differences between the two drugs that may influence the choice of treatment for individual patients.

Overall, the choice between Ozempic and Semaglutide will depend on the individual patient’s preferences and medical history. Both medications can be effective for weight loss, but the dosing schedule, side effects, and cost may vary between the two drugs. It is important to consult with a healthcare provider to determine the best treatment option for your specific needs and goals.

In conclusion, both Ozempic and Semaglutide are effective medications for weight loss in adults with type 2 diabetes and obesity. They work by increasing the levels of GLP-1 in the body, which can help control blood sugar levels and reduce appetite. While both medications have been found to be effective for weight loss, there are differences in their dosing schedule, side effects, and cost that may influence the choice of treatment for individual patients. Consult with a healthcare provider to determine the best option for your specific needs and goals.

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