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It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: Eli Lilly will start a lcinical trial for tirzepatide for people with type 1 diabetes, more details on Dexcom's 15 day G7 sensor, Ozepmic pill form tested, type 5 diabetes identified and more! Find out more about Moms' Night Out Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com Reach out with questions or comments: [email protected] Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX Our top story this week.. Eli Lilly takes the first steps toward getting tirzepatide approved for people with type 1 diabetes. Tirzepatide is sold under the brand names Mounjaro for type 2 and Zepbound for obesity. The main purpose of this study is to find out how well and how safely tirzepatide works in adults who have type 1 diabetes and obesity or are overweight. Participation in the study will last about 49 weeks. Official Title A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Efficacy and Safety of Tirzepatide Once Weekly Compared to Placebo in Adult Participants With Type 1 Diabetes and Obesity or Overweight This is a big deal because, even though many people with type 1 are able to get a prescription for tirzepatide, it’s not approved for T1D and so insurers won’t usually cover it. https://clinicaltrials.gov/study/NCT06914895 XX The use of drugs like Ozempic, Wegovy and Zepbound in people with type 1 diabetes has risen sharply over the past decade, a new study finds, even though there’s little information on the drugs’ safety and effectiveness for the condition. The family of medications called GLP-1 receptor agonists includes drugs like Wegovy, Zepbound, Ozempic, Mounjaro and Victoza. But the clinical trials of these medications specifically excluded people with type 1 diabetes, who are dependent on the hormone insulin to survive because they can’t make enough of their own. Drugmakers feared that using the GLP-1 medications with insulin might raise the chance of dangerously low blood sugar events, or hypoglycemia, and were unwilling to take the risk of studying them in people with type 1. For the study, which was published last month in the journal Diabetes, Obesity, and Metabolism, researchers at Johns Hopkins University reviewed the medical records of more than 200,000 people with type 1 diabetes from 2008 to 2023. They grouped the data in three-year periods, starting with October 2008 to September 2011 and ending with October 2020 to September 2023. GLP-1 medication use spiked, as well. Among adults with the highest category of obesity, about 4% used GLP-1 medications in 2008, and 33% did by 2023 – an 800% increase. But these are anecdotal reports and may not reflect instances in which people have side effects or complications like low blood sugar, which can be life-threatening. But Shin says what’s really needed is information from randomized, double-blinded studies, in which participants are followed forward in time and given either a drug or a placebo. https://www.cnn.com/2025/04/09/health/glp-1-type-1-diabetes-study/index.html XX Later this month the FDA will conduct a final meeting regarding a new, investigational compound (sotagliflozin) soda-GLIFF-a-zin that has been shown to Improve QoL and Reduce Long-term Complications for people with type 1 diabetes (T1D). The patient advocacy group Taking Control of Your Diabetes (TCOYD.org) is working to inform the T1D community about sotagliflozin - and to encourage people to sign a Change.org petition directed towards FDA. Last fall, the FDA declined to approve sotagliflozin due to concerns about a potential increased risk of diabetic ketoacidosis (DKA), despite this being a condition that people with T1D on insulin face and manage daily. While TCOYD respects FDA’s caution, the group stands by T1D patients and their physicians who, as a team, balance risks and benefits every day. https://tcoyd.org/petition/ XX Dexcom receives...

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Alternatives to GLP-1 Drugs for Employers. GLP-1 Drugs like Ozempic, Wegovy, Mounjaro and Zepbound cost employer $9,000-$10,000 per person per year... a cost that is financially unsustainable for many employer health plans. In considering alternatives to GLP-1 drugs, it is important to understand that they are only effective in conjunction with eating less... including eating less sugar. As Dr. Robert Lustig has pointed out, eating less refined sugar and high fructose corn syrup is the key to improving diabetes, metabolic syndrome and cardiovascular disease. Unfortunately, 90% of Family Practice primary care physicians believe that counseling patients on decreasing sugar consumption is ineffective. Fruit is a healthy alternative to eating sugar. Increase fruit consumption is associated with a 6% decrease in diabetes. However, only 12% of US adults eat the daily recommended allowance of fruit. There is a model of primary care that IS effective in improving nutrition, promoting weight loss and preventing/treating diabetes and that is Onsite, Near Site and Direct Primary Care. The company Serigraph used an onsite clinic, data measurement and incentive programs to keep their healthcare cost flat for 9 years while improving employee health an nutrition. Sources: "The Company that Solved Healthcare" by John Torinus AHealthcareZ video on Sugar and Dr. Robert Lustig: https://youtu.be/K8rdfeaM5uQ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884895/#:~:text=The%20study%20by%20Li%20et,be%20approximately%20200%20g/d. https://www.webmd.com/diet/ss/slideshow-stop-cravings https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399879/#:~:text=Several%20studies%20show%20differences%20between,to%20weight%20loss%20in%20women. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146324/ https://www.colorado.edu/asmagazine-archive/node/2047 AHealthcareZ is 400+ Healthcare Finance Educational Videos. 💥 BOOK: Check out Dr. Bricker’s Book 16 Lessons in the Business of Healing here: https://www.ahealthcarez.com/healthcare-money-campfire-stories-book AHealthcareZ Viewers Include: Employee Benefits Professionals, HR, CFOs, Insurance Brokers, Benefits Consultants, Doctors and Nurses in Leadership Roles, Hospital and Health System Administrators, Health Insurance Carrier and PBM Professionals, Pharma and Med Device Professionals, Academic Professors and Students in Healthcare Administration and Public Health. 90,000+ Views Per Month Across All Platforms. Visit AHealthcareZ.com to Subscribe to the Healthcare Finance Video Newsletter.

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In this episode of Medical Ethics, Steve Levine, Dom Sisti, and guest Johan Dellgren explore the challenges surrounding the equitable allocation of GLP-1 receptor agonists (GLP-1 RAs). As these medications gain recognition for their effectiveness in treating obesity and type 2 diabetes, the discussion explores the systemic barriers preventing equal access, including high costs, insurance coverage limitations, and broader health disparities. The panel emphasizes the importance of prioritizing those at highest medical risk while also addressing the root causes of healthcare inequities. Watch to learn more about the ethical considerations and potential solutions in ensuring these medications reach those who need them most. Time Stamps: 00:00 Introduction to GLP-1 Agonists and Ethical Considerations 03:38 Current Landscape and Insurance Coverage 06:04 Fair Priority Model and Ethical Principles 13:37 Application of Principles and Tiered Allocation 34:30 Challenges and Objections to the Framework 38:41 Future Considerations and Broader Applications #glp1 #MedicalEthics