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In this episode of the Talking Studies Series, I cover a fairly hot topic: GLP-1 receptor agonists (GLP-1RAs), the popular weight-loss drugs. Specifically, I cover a study that tested exercise, liraglutide (a GLP-RA), and liraglutide plus exercise as interventions for maintaining weight-loss. And, I zero in on how both the original liraglutide-free weight-loss period and the different interventions during the maintenance phase impacted lean mass—a proxy for muscle mass. --------------------------------------------------------------------------------------------------------------------------- Links from the video: Main study discussed: https://www.nejm.org/doi/10.1056/NEJMoa2028198 “Preserving Healthy Muscle during Weight Loss”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421125/ “A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity”: https://academic.oup.com/nutritionreviews/article/68/7/375/1821484?login=false “Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946208/ “GLP-1 receptor agonists: an updated review of head-to-head studies”: https://journals.sagepub.com/doi/10.1177/2042018821997320?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed --------------------------------------------------------------------------------------------------------------------------- More From Shortcut U: - Blog: https://shortcutu.substack.com/ - Free Beginner Lifting Program: https://open.substack.com/pub/shortcutu/p/the-beginners-build-program?r=qcnj7&utm_campaign=post&utm_medium=web - Free Spring Break Program: https://springbreakbuild.com/

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Welcome back to our channel where we provide you with the latest information on Diabetes management. Today we'll be diving deep into GLP-1, an essential hormone in the regulation of blood sugar levels. GLP-1, or glucagon-like peptide 1, is a hormone secreted by the intestines in response to food intake, playing a crucial role in maintaining blood sugar control and overall metabolic health. GLP-1 has multiple functions that benefit individuals with diabetes. Firstly, it enhances insulin secretion from the pancreas, allowing glucose to enter our cells and reduce blood sugar levels. Secondly, GLP-1 inhibits the release of glucagon, a hormone responsible for increasing blood sugar levels. By suppressing glucagon, GLP-1 helps control hyperglycemia and maintains balanced blood sugar levels. Wondering why additional interventions are needed if we already have GLP-1 naturally in our bodies? The natural GLP-1 is rapidly broken down by an enzyme called DPP4, limiting its effectiveness. GLP-1 receptor agonists and DPP4 Inhibitors come into play here. GLP-1 receptor agonists mimic the effects of GLP-1 with a longer half-life, enhancing insulin secretion and suppressing glucagon. DPP4 Inhibitors work by blocking the enzyme that breaks down GLP-1, allowing its beneficial effects on blood sugar control to persist. GLP-1, diabetes management, blood sugar control, insulin secretion, glucagon, DPP4 Inhibitors, GLP-1 receptor agonists, metabolic health, hyperglycemia, weight management #GLP1 #DiabetesManagement #BloodSugarControl Manage your blood sugar effectively and live a happier, healthier life. https://blogdiabetes.com/blood-sugar Key Moments: 01:07 glp-1 enhances insulin secretion 01:31 glp-1 inhibits the release of glucagon 00:02:01 GLP-1 influences appetite. 00:03:41 GLP-1 receptor agonists benefits. 04:01 glp-1 or glucagon like peptide 1 is a vital hormone in diabetes management 05:12 always consult your Healthcare professional to determine the best treatment approach for your specific needs 00:05:26 subscribe to our channel for more 00:05:33 foreign

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Not sure if your insurance covers a GLP-1 medication? 🤔 Here are the key questions you should ask to find out! Knowing the right questions can save you time, money, and hassle. Watch the video for all the details and share your experiences with insurance coverage below! 👇 #short