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Low testosterone in men, also known as low T, can lead to a variety of physical and emotional symptoms. In this video, we break down the most common signs of low testosterone in men—such as chronic fatigue, reduced sex drive, mood changes, muscle loss, and increased body fat. Understanding these symptoms can help you take action early. If you’ve been feeling off, it might be more than just stress or aging. Learn how low testosterone impacts men’s health and what you can do about it. A simple blood test can provide answers. Always consult a healthcare provider before beginning any treatment. Don’t ignore the signs—your health matters. low testosterone, low T symptoms, signs of low testosterone, men’s health, hormone imbalance in men, fatigue in men, decreased sex drive, muscle loss, testosterone levels, mood swings, men over 40, testosterone therapy, hormonal health, low T treatment, low testosterone causes, low libido, aging men health, testosterone deficiency, depression in men, health tips for men, male hormones
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Around 16% of Indian population suffer from different forms of sexual dysfunction with people suffering from this vascular dysfunction resorting to Phosphodiesterase type 5 (PDE5) inhibitors such as Viagra.
In fact, it has been found that the sales of this drugs has increased many fold.
But is this really a disease?
Sexual Dysfunction both in men & women is a vascular dysfunction, it is endothelial dysfunction.
In fact, it is an early sign of cardiovascular disease.
Sexual dysfunction is a problem of lack of blood flow. For erectile, our sexual organs needs increase in blood flow.
When there is stimulation of sexual activity, there is a signalling cascade that tells there is need for increase in blood flow for engorgement that allows for erection & penetration.
It is no brainer that our body, endothelial cells need to produce nitric oxide that stimulates blood flow.
Endothelial cells lines our blood vessels & when coupled with endothelial nitric oxide synthase converts semi essential amino acid- L-Argnine into nitric oxide. Our oral microbiome synthesise nitrate into nitrite which mixes with stomach acid to produce nitric oxide.
Nitric oxide binds to a receptor on enzyme called guanylyl cyclase This activates a message called cyclic GMP which dialates the blood vessels of sex organs & allows for increase of blood flow of sex organs, leading to erection.
However, if you are experiencing inflammation or oxidative stress, it could lead to endothelial dysfunction, disrupt the blood flow, causing sexual dysfunction. Even if your oral microbiome is imbalanced or you are consuming foods high in glyphosates, it could disrupt nitric oxide. Endothelial dysfunction in the vascular bed of sex organs is the same as Endothelial dysfunction in cerebral arteries in brain, Endothelial dysfunction in coronary arteries & more.
The effectiveness of PDE-5 inhibitors & other supplements for sexual dysfunction depends upon Nitric oxide. Nitric Oxide activates Cyclic GMP while PDE-5 inhibitors prevents the breakdown of Cycle GMP. If you are experiencing functional loss of nitric oxide production, there is no activation of cycle GMP & these drugs are not equipped to do their job.
Citations
https://pmc.ncbi.nlm.nih.gov/articles/PMC8109295/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4806684/
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