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Semaglutide, a medication often used for the treatment of type 2 diabetes, has recently gained attention for its potential as a weight loss aid. Health authorities around the world have been evaluating the efficacy and safety of semaglutide for weight loss, with some granting official approval for this new indication. This development has sparked excitement among healthcare providers and patients alike, as obesity continues to be a significant health concern globally.

Regulatory Approval in the United States

In June 2021, the U.S. Food and Drug Administration (FDA) approved semaglutide for chronic weight management in adults with a body mass index (BMI) of 30 kg/m² or greater, or with a BMI of 27 kg/m² or greater in the presence of at least one weight-related comorbidity, such as hypertension or type 2 diabetes. This marked a significant milestone in the treatment of obesity, as there are limited pharmacological options available for long-term weight management.

The FDA’s approval was based on the results of several clinical trials, including the STEP program, which demonstrated the efficacy of semaglutide in promoting weight loss when used in conjunction with diet and exercise. Common side effects of semaglutide include nausea, diarrhea, and constipation, but overall, the medication was well-tolerated in clinical trials.

Healthcare providers in the United States now have an additional tool in their arsenal for managing obesity, a condition that affects millions of Americans and is associated with numerous health risks. Semaglutide offers a novel approach to weight loss by targeting the body’s appetite control system, leading to reduced food intake and ultimately, weight reduction.

European Medicines Agency Evaluation

The European Medicines Agency (EMA) has also been evaluating semaglutide for weight management, although as of [insert date], the medication has not yet received official approval for this indication in the European Union. However, the EMA’s Committee for Medicinal Products for Human Use (CHMP) has recommended granting marketing authorization for semaglutide for weight loss.

The CHMP’s recommendation was based on the positive results of clinical trials, which showed that semaglutide was more effective than placebo in achieving weight loss and improving metabolic parameters. The most common side effects reported with semaglutide were gastrointestinal in nature, similar to the findings in the FDA-approved trials.

If approved by the European Commission, semaglutide could become a valuable treatment option for individuals struggling with obesity in the EU. The availability of semaglutide for weight management would address an unmet need in the region and provide healthcare providers with a new tool for helping patients achieve their weight loss goals.

Global Impact and Future Outlook

Outside of the US and EU, other health authorities are also evaluating semaglutide for weight loss, with the potential for additional approvals in the near future. The global obesity epidemic has prompted a renewed focus on finding effective treatments for weight management, making semaglutide a promising candidate for addressing this public health issue.

As more health authorities approve semaglutide for weight loss, the medication is poised to have a significant impact on the field of obesity medicine. Healthcare providers will have access to a new class of medications that target appetite regulation and weight control, offering patients a much-needed solution for managing their weight and improving their overall health.

In the coming years, ongoing research and real-world evidence will further elucidate the long-term benefits and safety profile of semaglutide for weight management. With continued advancements in obesity treatment, patients can look forward to more effective and personalized approaches to achieving sustainable weight loss and improving their quality of life.

Summary:

In summary, the official approval status of semaglutide for weight loss by health authorities is a significant development in the field of obesity medicine. The FDA’s approval in the United States and the CHMP’s positive recommendation in the EU represent important milestones in the recognition of semaglutide as an effective treatment for weight management. As more health authorities around the world evaluate semaglutide for weight loss, healthcare providers and patients can expect to have access to a new class of medications that offer innovative solutions for addressing the global obesity epidemic.

With ongoing research and real-world evidence, semaglutide is poised to play a key role in helping individuals achieve sustainable weight loss and improve their overall health. As the field of obesity medicine continues to evolve, semaglutide stands out as a promising option for addressing the complex challenges of obesity and providing patients with effective strategies for long-term weight management.

Ultimately, the official approval of semaglutide for weight loss by health authorities opens up new possibilities for healthcare providers to better support patients in their weight loss journey and pave the way for a healthier future for individuals struggling with obesity.

Lu Lu’s hesitation instantly cheered up Yun Yang.

Lu Lu’s hesitation meant that this method actually existed, but it would be very costly to use.

“I don’t ask for much, as long as I can make a certain breakthrough on the existing basis. I believe you can also sense that there is a breath of water flowing in the underground river about 300 feet below. As long as I can dive down, I can escape from this and get out of this disaster. Otherwise, everything will be over and I will die.”

Yun Yang already knew that the current situation was the only place where there was hope for survival.

But knowing where there was hope was one thing, but it was also an unavoidable reality that he could not reach the destination at all because of his current cultivation.

The space closed by Mr. Nian was not only the sky and the ground, but also a considerable range under the ground, as deep as a hundred feet below the bottom, all within the scope of the life restricted area set by Mr. Nian.

However, further down was an area that Mr. Nian could not control, and it was also a new and unfamiliar area that his sword energy had never penetrated!

Yun Yang could sense the underground river three hundred feet below with the water source sensing of the Holy Water Art, but the pressure under the bottom layer was getting worse and worse. The more feet below, the more pressure increased. Yun Yang’s current position was already the limit of his own body, and he could no longer dive down. He knew where the chance of survival was, but he could only sigh at the river.

In fact, the underground river on the other side existed under all regions of the entire continent, the only difference was the depth.

And the underground river that Yun Yang sensed was particularly deep, as deep as three hundred feet!

Yun Yang felt that this was the most unlucky place for him. Where in the entire continent would the underground river be so deep? Three hundred feet below the ground?

But he happened to encounter it.

Yun Yang had some strange conjectures about this: there was no water source within three hundred feet below the ground here, which was really an extraordinary wonder! Leading to the current dilemma. Yun Yang had been drooling at the underground river for twenty days! But there was no way to think of it.

Of course, it was also because this underground river was deep enough, beyond the scope of Mr. Nian’s spiritual sense, otherwise, there would be no chance of survival!

This was the only chance of survival, but Yun Yang’s own strength was not enough, and it was difficult to reach it, which became an impossible strategy. At this time, there was another enemy, which gave Yun Yang a little more breathing room and time to recover, but at the same time brought bad news about the control of the spirit formation. If he didn’t respond, he would really have no way out!

Now, seeing Lu Lu’s hesitation, Yun Yang saw a glimmer of hope to escape, and couldn’t help urging her. There was no hesitation at this moment. It was serious to do it quickly. If he hesitated like this, it would be too late again!

Yun Yang clearly sensed that the spiritual energy of the surrounding heaven and earth was being squeezed out in a slow, but extremely real way, as if being squeezed by someone.

This was obviously the control of the spirit formation slowly taking shape.

This place is about to become a soulless place where all magical powers are ineffective, just like Zilong City. Time is really running out for me.

After all, once the soul-controlling formation is fully operational, my physical body will be annihilated by the earth immediately because of the malfunction of all magical powers!

“Ah, ah…”

Lu Lu’s voice was very sad at this moment.

There is indeed a way…

But the cost is high, so expensive that I don’t know whether to implement it. Once implemented, the consequences are unimaginable-

In fact, in Lu Lu’s opinion, it is better to die like this.

Because, even if the physical body is extracted and killed by the soul-controlling formation, the soul still exists, and can be reborn and transformed into a human.

At that time, there is still a little vitality.

And I will go with Yun Yang, and there will be no loss.

But if I take this method, it is equivalent to suicide!

Suicide with the soul and soul destroyed!

Then there will really be no afterlife… Completely turned into nothingness!

Lulu can indeed force all the current energy into Yun Yang’s meridians in a very short time, and let all the life force and the cause and effect of good and evil fill it rapidly.

Then, one of Yun Yang’s abilities is directly raised to a whole new level.

This ability is called Hongmeng Borrowing Method! Another well-known name is called Star Borrowing Power! It is to extract the power of the stars in the sky and inject it into the body in an instant!

But… Lulu doesn’t want to do this at all.

Otherwise, Yun Yang would have been in danger or even dying before, and Lulu didn’t mention it after many inquiries.

Lulu has three concerns. The first is that this battle came unexpectedly. From the beginning, Yun Yang fell into an absolute disadvantage. His body, mind and soul were constantly hurt. What’s more, if there is a little gap, even if this method needs a certain buffer space to be implemented, there was no room for implementation before.

The second is that Yun Yang’s cultivation is still too low now. Once he does this, more than 99% of the possibility is not that some ability is improved… but that his body explodes on the spot! The soul is destroyed!

The power of the stars in the sky, even if each star only gives a ray of starlight power, gathered in Yun Yang’s body, how can he bear it?

Just a flesh and blood body, but has to bear such a huge force…

This result is more serious than Yun Yang’s direct death, because there are several different ways of death, such as Yun Yang’s exhaustion of blood and energy, and his body is completely damaged. In this way, his soul is still there. As long as Mr. Nian is gone within a certain time limit, with Lu Lu’s current deep understanding of the soul, there is a considerable chance that Yun Yang’s soul can be reunited and resurrected!

Or reincarnation.

But if Hongmeng fails to borrow the law, Yun Yang will really perish immediately, and it will be a disaster, and he can’t die again!

This is also the fundamental reason why Yun Yang asked many times before, but Lu Lu refused to tell him directly!

But the situation is different now. Once the soul-controlling formation is formed, Yun Yang’s various magical powers will fail again, and the method that Lu Lu had planned will be completely hopeless because the Holy Water Jue, the Blood Evil Method and other skills can no longer be used. This is why she had to mention the method of Hongmeng Borrowing!

But after Lu Lu’s repeated judgments, with Lu Lu’s ability to use it, plus the toughness of the meridians brought by Yun Yang’s continuous consumption of natural materials and treasures during this period, and the endless potential of medicinal power in his body…

The hope of success in implementing Hongmeng Borrowing is still less than one tenth of one tenth!

After all, even if it is to force the growth of seedlings, it also requires that the seedlings have a considerable foundation and grow to a certain height.

With Yun Yang’s current size, there are only three possible results of rashly using this method.

The first possible result is to explode and die on the spot, and the soul is extinct. This possibility is more than 90%, nearly 100%!

The second possibility is to become an idiot. This is still the case when this method is used properly and succeeds, but the brain will be destroyed by the strong energy impact in the process.

And with such a result, even Lulu can’t recover for him, and can only accompany a dementia for the rest of his life… Thinking about it, Lulu feels chilled.

As for the third possibility, it is the best result. Successfully borrowing the law, even escaping from the dead, but he will still be seriously injured afterwards, and even lose the ability to practice from then on, and become an ordinary person. Even becoming an ordinary person, he must be the kind of ordinary person with long-term physical illness, and the kind that cannot enjoy the life span of ordinary people.

And Lulu will become a lotus seed again, floating between heaven and earth…

And these possibilities all have a premise: the Nine Aspects of the Divine Power and the power of transformation will be lost forever!

Because exercising the Hongmeng borrowing method is equivalent to completely draining all the attributes of Yun Yang’s qualifications!

Five Elements Gathering Power, Heaven and Man Unity, Yin and Yang Compatibility, Hongmeng Borrowing Method!

Of course, there is another possibility: Yun Yang not only did not die, but his cultivation level was greatly improved, and he became invincible in the world!

But this possibility is not very small… Lu Lu said that she did not even think about this possibility, and she really did not dare to think about it.

This possibility… Lu Lu guessed that there was about a one in a hundred billion chance…

But Lu Lu also knew the situation. Yun Yang really had no time now. The spirit control formation had already been set up outside. If he did not take action, he would really have no chance.

Even though Lu Lu did not want Yun Yang to take such a risk, she could only support him at this moment.

Because this method of 100% death and no chance of survival was really the only hope now!

If you don’t do this, you can only wait here to become a corpse, and you will still be annihilated and doomed!

The only thing is…

“It’s just that even if this method is implemented, it still needs a chance… Because at the moment of activation, there will be a breath escaping anyway; after all, there are still two peerless masters setting up above… With their spiritual sense, at that time, they only need to send sword energy to the place where the breath is emitted, and everything will be over, and it will end one step earlier…”

Yun Yang racked his brains to think.

Now we have a coping strategy, but how can we contain the two peerless masters above?

Let them distract their attention for a while, at least for a while!

…

Above, two figures were busy, constantly throwing a jade stone emitting colorful light in various directions. The moment it landed, it deeply entered the soil layer and disappeared.

A small-scale spirit control formation can be set up quickly as long as there are enough materials and Xuanqi cultivation.

For the two of them, it really doesn’t take much effort. At this moment, there is only one corner left to complete the spirit control formation.

As long as the arrangement is completed, no matter whether Yun Zun is now transformed into wind or water, or into any other state, he will remove the ability to transform and return to human form!

Or, it is unknown whether the body is directly crushed by the underlying power!

The two were about to scatter the materials in their hands to complete the last bit of arrangement.

At this moment, a strange wave came from under the ground.

Yun Zun moved?

Seeing the most terrifying spirit-controlling formation coming again, will they make a final desperate struggle? !

Mr. Nian frowned, and couldn’t help but concentrate, the long sword in his hand began to hum.

Another person also floated down from the air, standing beside Mr. Nian, looking at the area where the movement occurred with a serious expression.

However, the next moment, both of them changed their expressions at the same time.

“We’ve been fooled!”

Because, behind the two of them, a strong and direct energy fluctuation suddenly appeared, and a colorful light suddenly shot out of the ground!

Whoosh!

The light instantly reached a height of hundreds of feet above the air!

…………

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