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Learn more at Penn Medical Group: https://pennmedicalgroup.com/ or call us at (610) 321-7777 for a free consultation. Semaglutide is a medication initially approved for the treatment of type 2 diabetes. However, its weight-loss properties have gained significant attention, and it's now also approved for weight management in certain patients. Let's compare semaglutide to some other weight loss medications: Semaglutide (Wegovy, Ozempic) Mechanism of Action: It is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the function of GLP-1. This leads to reduced appetite and slowed gastric emptying, among other effects. Efficacy: Some studies have shown significant weight loss with semaglutide. One study showed a mean weight loss of around 15% of initial body weight in those taking semaglutide for weight management. Side Effects: Nausea, vomiting, diarrhea, constipation, abdominal pain, and increased risk of diabetic retinopathy. Orlistat (Alli, Xenical) Mechanism of Action: Works in the gut to inhibit the action of lipases, which are enzymes that break down fats. As a result, it reduces the absorption of dietary fats. Efficacy: Moderate weight loss, typically around 5-10% of initial body weight. Side Effects: Gastrointestinal issues like oily stools, flatulence, and frequent bowel movements. It may also reduce the absorption of fat-soluble vitamins. Phentermine-Topiramate (Qsymia) Mechanism of Action: Combines two drugs. Phentermine suppresses appetite and topiramate (originally an antiepileptic drug) appears to work on several pathways related to appetite, satiety, and energy expenditure. Efficacy: Studies have shown average weight loss of about 8-10% of initial body weight. Side Effects: Increased heart rate, birth defects if taken during pregnancy, tingling in the hands and feet, insomnia, and dry mouth. Naltrexone-Bupropion (Contrave) Mechanism of Action: Naltrexone is an opioid antagonist and bupropion is an antidepressant. Together, they work on the central nervous system to reduce appetite and increase energy expenditure. Efficacy: Studies have shown an average weight loss of about 5-9% of initial body weight. Side Effects: Nausea, constipation, headache, vomiting, dizziness, insomnia, and dry mouth. Liraglutide (Saxenda) Mechanism of Action: Another GLP-1 receptor agonist, similar to semaglutide. Efficacy: Studies have shown a weight loss of about 5-9% of initial body weight. Side Effects: Nausea, diarrhea, constipation, abdominal pain, and increased risk of pancreatic disease. Benzphetamine (Didrex), Phendimetrazine, and Diethylpropion: Mechanism of Action: Sympathomimetic appetite suppressants. Efficacy: Modest weight loss. Side Effects: Increased blood pressure, palpitations, dry mouth, and insomnia. When considering any weight loss medication, the benefits should always be weighed against potential risks, and it's essential to discuss with a healthcare provider. Weight loss medications are typically used in combination with diet, exercise, and behavior modification for best results. Also, it's essential to note that not all patients will respond to medications in the same way, and individual results can vary.

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