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#diabetes #weightloss #antihungermedicine Weight loss by diabetes drug linked to "anti-hunger" molecule, finds study Researchers from Stanford Medicine and Harvard Medical School have discovered an โ€œanti-hungerโ€ molecule that is produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The finding published in the journal Nature Metabolism revealed the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite which may help to discover a new class of weight loss drugs. Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug. Although this amount of weight loss is modest when compared with the 15% or more often seen by people taking semaglutide drugs, the discoveries that led to those drugs also grew from observations of relatively minor, but reproducible, weight loss in people taking first-generation versions of the medications. โ€œUntil now, the way metformin, which is prescribed to control blood sugar levels, also brings about weight loss has been unclear,โ€ said Jonathan Long, PhD, an assistant professor of pathology. โ€œNow we know that it is acting through the same pathway as vigorous exercise to reduce hunger. Understanding how these pathways are controlled may lead to viable strategies to lower body mass and improve health in millions of people.โ€ The researchers observed obese laboratory mice who were given metformin and found increased levels of lac-phe in their blood. They ate less than their peers and lost about 2 grams of body weight during the nine-day experiment. In the study, Long and colleagues analyzed blood plasma samples from people with Type 2 diabetes before and 12 weeks after starting metformin treatment. They found significant increases in lac-phe levels post-metformin. Additionally, among 79 participants in a multi-ethnic atherosclerosis study taking metformin, those on the drug had higher circulating lac-phe levels compared to non-users. Moreover, a statistical analysis of individuals in the atherosclerosis study who experienced weight loss over the study and follow-up period revealed a significant connection between metformin usage, lac-phe production, and weight reduction. โ€œIt was nice to confirm our hunch experimentally. The magnitude of effect of metformin on lac-phe production in mice was as great as or greater than what we previously observed with exercise. If you give a mouse metformin at levels comparable to what we prescribe for humans, their lac-phe levels go through the roof and stay high for many hours.โ€ said Long. โ€œThese findings suggest there may be a way to optimize oral medications to affect these hunger and energy balance pathways to control body weight, cholesterol and blood pressure. I think what weโ€™re seeing now is just the beginning of new types of weight loss drugs.โ€ Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. ๐Ÿ”— Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ ๐Ÿ“š Explore More With Us: ๐Ÿ“Œ Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ ๐Ÿ“Œ Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Hate Cardio? Still burn fat this way #fatloss #fatlosstips #weightlosstips #metabolism You hate cardio? You're not alone. Running miles, dripping sweat, staring at a treadmill โ€” it's not for everyone. But hereโ€™s the truth: ๐Ÿ‘‰ You donโ€™t need to suffer through cardio to burn fat. ๐Ÿง  Instead, use this 3-part, science-backed strategy: โœ… 1. Lift Weights (Build Muscle โ†’ Raise Metabolism) ๐Ÿ’ก Why it works: Muscle is metabolically active. The more you have, the more fat your body burns โ€” even while resting. Plus, resistance training activates EPOC (Excess Post-Exercise Oxygen Consumption), which keeps your body burning calories for hours after the workout. ๐Ÿ“š Paoli et al. (2012) โ€“ Journal of Translational Medicine โ†’ โ€œResistance exercise, especially with short rest intervals, significantly increases post-exercise oxygen consumption and fat oxidation.โ€ โ†’ RT creates a longer fat-burning window than cardio. [Link to study] โœ… 2. Walk More (NEAT = Non-Exercise Activity Thermogenesis) ๐Ÿ’ก Why it works: Even without hitting the gym, your daily movements โ€” like walking, standing, fidgeting โ€” can burn hundreds of calories per day. This is called NEAT, and it can account for up to 15โ€“50% of your daily energy use. ๐Ÿ“š Levine JA (2007) โ€“ Mayo Clinic Proceedings โ†’ โ€œNEAT plays a critical role in daily energy expenditure and obesity management.โ€ โ†’ Small movements across the day add up to significant fat burn. [Link to study] โœ… 3. Eat Protein (GLP-1 Activation + Muscle Preservation) ๐Ÿ’ก Why it works: Protein does more than support muscle โ€” it increases GLP-1, a gut hormone that controls hunger and insulin response. Protein also preserves lean mass during fat loss, helping you maintain metabolic rate. ๐Ÿ“š Westerterp-Plantenga et al. (2009) โ€“ American Journal of Clinical Nutrition โ†’ โ€œHigher protein intake during weight loss improves satiety, increases thermogenesis, and helps preserve fat-free mass.โ€ [Link to study] ๐Ÿ” Final Takeaway โŒ You donโ€™t need to run. โŒ You donโ€™t need to suffer. โœ… You need a better strategy. Lift. Walk. Eat protein. Thatโ€™s how you burn fat fast โ€” and sustainably. ๐Ÿท Hashtags #BurnFatFast #FatLossTips #NoCardioNeeded #WeightLossScience #SmartFatBurning #NEAT #GLP1 #EPOC #FitnessForBusyPeople #ScienceBackedFatLoss Burn Fat Fast #1: Slept 4, 5, or 6 Hour ? #fatloss #weightlosstips #fatlosstips #glp1 #sleep https://youtube.com/shorts/wQsQPiwuO-s Burn Fat Fast #2: Hate Cardio? Still Burn Fat. #fatloss #fatlosstips #weightlosstips #glp1 https://youtube.com/shorts/iOVx1CmbUpg Burn Fat Fast #3: Still Eating Rice and Bread? Do This. #glp1 #fatloss #weightlosstips #fatlosstips https://youtube.com/shorts/2RcBmhRVsY8

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