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In episode 197 of the Thyroid Answers podcast, I discuss GLP-1 with Jeff Thurston. In this episode, we discuss: - Where GLP-1 is made in the body - What GLP-1 does in the body. - The role of GI bacteria in GLP-1 production. - The role of diet in GLP-1 production. - The role of lifestyle on gut flora balance and GLP-1 production. - The role of probiotics - Strategies for improving gut bacteria and natural GLP-1 production - And more... Jeff is the co-owner of Master Supplements and US Enzymes. He has a degree in biology and chemistry. He began his career as a virologist under a government security clearance, working with extremely virulent pathogens. As he grew to understand the purpose of the work, he left to begin a career in sales and sales management. While working in organic agriculture in the Central Valley of CA, he met Randy Porubcan. Both were speakers at a meeting. Being of similar age, similar backgrounds, college in the upper midwest, they hit it off. That was in 1995. Randy suggested they start a business one day. In 2002, Randy called Jeff and asked if he was ready. He said yes, and they started their business, Master Supplements. In September of 2019, they purchased US Enzymes, adding a product line of highly efficacious enzyme supplements to their line of probiotics. Jeff can be found at: usenzymes.com https://master-supplements.com Previous episode with Jeff Thurston: TAP 84: Introduction to Probiotics

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Semaglutide has gained popularity in recent years as a potential treatment for obesity. This article will explore how semaglutide works for weight loss, breaking down the science behind its mechanism of action. Understanding how this medication works can provide valuable insights into its effectiveness and potential side effects.

The Science Behind Semaglutide

First and foremost, it’s essential to understand what semaglutide is and how it works. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the effects of GLP-1 in the body. GLP-1 is a hormone that is released by the gut in response to food intake. It helps regulate insulin secretion, reduce appetite, and promote weight loss.

When semaglutide is injected, it binds to GLP-1 receptors in the body, activating them and mimicking the effects of natural GLP-1. This leads to increased insulin secretion, decreased glucagon secretion, slowed gastric emptying, and increased satiety. These effects work together to lower blood sugar levels, reduce appetite, and ultimately lead to weight loss.

Semaglutide and Appetite Regulation

One of the key ways that semaglutide works for weight loss is through appetite regulation. By binding to GLP-1 receptors in the brain, semaglutide can reduce feelings of hunger and increase feelings of fullness. This can help individuals consume fewer calories and lose weight over time.

Studies have shown that semaglutide can lead to significant reductions in calorie intake, which contributes to weight loss. By helping individuals feel more satisfied with smaller portions of food, semaglutide can support long-term weight management goals.

Metabolic Effects of Semaglutide

In addition to appetite regulation, semaglutide also has metabolic effects that contribute to weight loss. By increasing insulin secretion and decreasing glucagon secretion, semaglutide helps improve glucose control and reduce blood sugar levels. This can be particularly beneficial for individuals with type 2 diabetes who are struggling to manage their weight.

Furthermore, semaglutide can help improve lipid profiles by reducing levels of triglycerides and LDL cholesterol. These metabolic effects not only promote weight loss but also support overall cardiovascular health.

Potential Side Effects of Semaglutide

While semaglutide can be an effective treatment for weight loss, it is essential to be aware of potential side effects. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These gastrointestinal side effects usually improve over time as the body adjusts to the medication.

In rare cases, semaglutide can also lead to more serious side effects such as pancreatitis or thyroid tumors. It’s essential to discuss the risks and benefits of semaglutide with a healthcare provider before starting treatment, especially for individuals with a history of pancreatitis or thyroid disease.

Conclusion

In conclusion, semaglutide works for weight loss by mimicking the effects of GLP-1 in the body. By regulating appetite, improving glucose control, and promoting metabolic health, semaglutide can support individuals in achieving their weight loss goals. However, it’s crucial to consider potential side effects and discuss the risks and benefits with a healthcare provider before starting treatment with semaglutide.

FAQ:

Q: How long does it take to see results with semaglutide for weight loss?

A: While individual results may vary, many people start to see weight loss within the first few weeks of starting treatment with semaglutide. Significant weight loss can typically be seen within a few months of consistent use.

Q: Is semaglutide FDA-approved for weight loss?

A: Yes, semaglutide has been FDA-approved for chronic weight management in adults with obesity or overweight who have at least one weight-related condition. It is available in a higher dose formulation specifically for weight loss.

Q: Can anyone use semaglutide for weight loss?

A: Semaglutide is generally safe and effective for most individuals, but it may not be suitable for everyone. It’s essential to consult with a healthcare provider to determine if semaglutide is the right treatment option for you.

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