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A 65-year-old woman with lifelong obesity, diabetes, sleep apnea, recent cancer surgery—and now, elevated LDL and BP. Where do you begin? In this episode of Case by Case, our panel dissects a highly relatable post-op metabolic patient profile and reveals how real-world prescribing decisions evolve when balancing obesity, cardiometabolic risk, and delayed access to bariatric surgery. 💊 When should you switch from dulaglutide to tirzepatide? 🧠 Do you titrate slowly for tolerance—or fast for efficacy? 🔍 And how do you defend SGLT2 inhibitors in patients with complex risk profiles like UTIs or CKD? 📚 Key Takeaways: • GLP-1 potency comparisons: dulaglutide vs. semaglutide vs. tirzepatide • When weight loss ≠ glycemic control—and how to balance both • SGLT2 side effects: myths vs. actual contraindications • Importance of not abandoning powerful therapies too soon • Pre-surgical weight loss strategies while on a waitlist 🎓 Meet the Experts: • Dr. Marie E. McDonnell (Harvard): Expert in diabetes care delivery and obesity management. • Dr. Jan N. Basile (MUSC): Cardio-renal-metabolic educator with a primary care focus. • Dr. Nihar R. Desai (Yale): Outcomes researcher and cardiologist shaping population-level strategy. 💬 “Sometimes, the problem isn’t the patient—it’s the potency of the drug.” 🩺 Register to claim CME for this panel discussion plus more: https://www.cmemeeting.org/online-cme-courses/10th-diabetes-spring-conference 👍 Like, comment, and subscribe for expert breakdowns every episode. ________________________________________

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Obesity is a widespread health issue that affects millions of people worldwide. Many individuals struggle to lose weight through traditional methods such as diet and exercise, leading them to explore alternative treatment options. One such option that has gained popularity in recent years is the use of semaglutide for weight loss in non-diabetics. Semaglutide is a medication originally developed for the treatment of type 2 diabetes but has shown promising results in aiding weight loss in individuals without diabetes.

Semaglutide Mechanism of Action

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These medications work by mimicking the effects of the natural hormone GLP-1, which is responsible for regulating blood sugar levels, appetite, and body weight. By activating GLP-1 receptors in the brain, semaglutide helps to reduce hunger, increase feelings of fullness, and regulate insulin secretion, leading to weight loss.

Additionally, semaglutide slows down the emptying of the stomach, which helps to control appetite and reduce calorie intake. This mechanism of action makes semaglutide an effective treatment for obesity in individuals without diabetes, as it targets multiple factors contributing to weight gain.

Semaglutide Dosage and Administration

The recommended dose of semaglutide for weight loss in non-diabetics is 2.4 mg once weekly, administered via subcutaneous injection. This dosage has been shown to be effective in promoting weight loss and improving metabolic parameters in clinical trials. It is important to follow the prescribed dosing schedule and administration instructions provided by a healthcare provider to ensure the best results.

Healthcare providers may adjust the dosage of semaglutide based on individual response and tolerance to the medication. It is important to communicate any side effects or concerns with a healthcare provider to determine the most appropriate dosage for achieving weight loss goals.

Potential Side Effects of Semaglutide

Like any medication, semaglutide may cause side effects in some individuals. Common side effects of semaglutide include nausea, vomiting, diarrhea, and abdominal discomfort. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication.

In rare cases, semaglutide may cause more serious side effects such as pancreatitis or thyroid tumors. It is important to seek medical attention if experiencing severe or persistent side effects while taking semaglutide for weight loss.

Benefits of Semaglutide for Weight Loss

In addition to aiding weight loss, semaglutide has been shown to offer several health benefits for individuals with obesity. These benefits include improved glycemic control, reduced risk of cardiovascular events, and improved quality of life. Semaglutide can help individuals achieve sustainable weight loss and improve overall health outcomes when used as part of a comprehensive weight management plan.

Overall, semaglutide is a promising treatment option for individuals with obesity who have struggled to lose weight through traditional methods. By targeting multiple factors contributing to weight gain and offering additional health benefits, semaglutide can help individuals achieve their weight loss goals and improve their overall health.

Combination Therapy with Semaglutide

In some cases, healthcare providers may recommend combining semaglutide with other weight loss medications or interventions to enhance the effectiveness of treatment. Combination therapy may include medications that target different mechanisms of action to further promote weight loss and improve metabolic outcomes.

Combining semaglutide with lifestyle modifications such as diet and exercise can also enhance the results of weight loss treatment. Healthcare providers will tailor treatment plans to individual needs and goals, ensuring a comprehensive approach to weight management with the use of semaglutide.