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Josh Gad's SHOCKING Weight-Loss Drug Experience! (Side Effects Forced Him To STOP!) Hey everyone, and welcome back to the channel! Today, we're diving into a topic that's been making headlines: Josh Gad's recent revelation about his experience with weight-loss drugs. The beloved actor, known for his roles in Frozen and Beauty and the Beast, recently shared his story about having to stop taking a weight-loss medication due to some unpleasant and concerning side effects. He expressed his disappointment, saying he was "really bummed out" by the experience. This story has sparked a huge conversation online about the pressures of weight loss, the potential dangers of these drugs, and the importance of prioritizing health over quick fixes. In this video, we'll unpack Josh Gad's story, explore the potential side effects of weight-loss medications, discuss the broader context of weight loss in Hollywood, and offer some healthier, more sustainable approaches to achieving your health goals. Weight-loss medications, while sometimes effective in the short term, can come with a range of potential side effects. These side effects vary depending on the specific drug and the individual's health condition. Some common side effects include nausea, vomiting, diarrhea, constipation, headaches, dizziness, insomnia, and anxiety. In more serious cases, some medications have been linked to increased heart rate, high blood pressure, liver damage, kidney problems, and even psychological issues. It's important to emphasize that this is not an exhaustive list, and it is crucial to do your own research and consult with a qualified healthcare professional to understand the specific risks associated with any weight-loss medication you are considering. It is also vital to remember that the long-term effects of many weight-loss drugs are still not fully understood. Hollywood is notorious for its unrealistic beauty standards and the immense pressure on actors and actresses to maintain a certain physique. This pressure can lead individuals to try extreme measures, including fad diets, rigorous exercise regimes, and, as in Josh Gad's case, weight-loss medications. The pressure is often amplified by social media, where celebrities are constantly scrutinized and judged based on their appearance. This culture of body shaming and unrealistic expectations can have a devastating impact on mental and physical health. It's crucial to promote body positivity and acceptance in the entertainment industry and beyond. We need to celebrate diversity in body types and challenge the notion that there is only one ideal of beauty. Josh Gad's experience with weight-loss drugs serves as a valuable reminder that there are no easy solutions to weight management. It's crucial to approach weight loss with a balanced perspective, prioritize health over appearance, and consult with medical professionals before trying any new treatment, especially medication. Remember, sustainable weight loss is a journey, not a race. Focus on making healthy lifestyle changes that you can maintain in the long term. Let's shift the conversation away from quick fixes and towards a more holistic and compassionate approach to health and well-being. What are your thoughts on this? Share your experiences and insights in the comments below. Don't forget to like this video and subscribe to the channel for more content like this. Thanks for watching! Josh Gad, weight loss, weight loss drugs, weight loss medication, side effects, health, celebrity weight loss, Hollywood weight loss, diet, exercise, fitness, nutrition, healthy living, body image, body positivity, weight loss journey, Josh Gad weight loss, weight loss story, celebrity health, weight loss tips #JoshGad #WeightLoss #WeightLossDrugs #WeightLossMedication #SideEffects #Health #CelebrityWeightLoss #HollywoodWeightLoss #Diet #Exercise #Fitness #Nutrition #HealthyLiving #BodyImage #BodyPositivity #WeightLossJourney #JoshGadWeightLoss #WeightLossStory #CelebrityHealth #WeightLossTips Stay Tune With The Star Gossip. Thank You For Your Support Good bye
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Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity NEJM : DOI: 10.1056/NEJMoa2302392 Orforglipron es un agonista oral no peptídico del receptor GLP-1 que se está desarrollando para el control del peso y el tratamiento de la diabetes tipo 2. Orforglipron actúa como un potente agonista parcial del receptor GLP-1. GLP-1 (Péptido similar al glucagón-1) es una hormona que juega un papel en la regulación de la glucosa y el control del apetito. Orforglipron tiene un mecanismo único de activación del receptor GLP-1. Produce señalización cAMP similar a la producida por el GLP-1 nativo. Sin embargo, conduce a una baja activación de la vía β-arrestina, que regula la internalización del receptor. Este efecto de señalización sesgada puede contribuir a su eficacia. 272 participantes fueron asignados aleatoriamente para recibir diferentes dosis de orforglipron: 12 mg, 24 mg, 36 mg, etc. Participantes del Estudio: El estudio se centró en participantes que tenían obesidad (índice de masa corporal IMC 30) o estaban con sobrepeso (IMC entre 27 a 30) con al menos una condición relacionada con el peso, como hipertensión, dislipidemia, enfermedad cardiovascular o apnea obstructiva del sueño. Se requería que los participantes tuvieran un peso corporal estable (5% de ganancia o pérdida) durante los 3 meses anteriores a la aleatorización. Semana 26: Orforglipron 12 mg: -9.0 kg Orforglipron 24 mg: -12.3 kg Orforglipron 36 mg: -12.9 kg Orforglipron 45 mg: -13.3 kg Placebo: -2.1 kg Semana 36: Orforglipron 12 mg: -9.8 kg Orforglipron 24 mg: -13.6 kg Orforglipron 36 mg: -14.2 kg Orforglipron 45 mg: -15.4 kg Placebo: -2.4 kg Estos valores representan el cambio medio estimado en el peso corporal desde el inicio para cada grupo. Se observó que la reducción de peso dependía de la dosis, con dosis más altas de Orforglipron resultando en una mayor pérdida de peso en comparación con el grupo placebo.
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