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Downsized News: Breakthroughs and Industry Shifts in GLP-1 Treatments In this episode of the Downsized News, Laraine and Christopher Durham deliver the latest updates on GLP-1 medications on Monday, June 2nd, 2025. Key topics include significant data releases by Eli Lilly at the upcoming American Diabetes Association's Scientific Sessions concerning Tirzepatide's effects on kidney function and weight loss compared to Semaglutide. The episode also explores new forms of GLP-1 treatments, such as the Orfroglipron pill and the Retatrutide triple-action hormone, as well as an updated weekly insulin option by Lilly. Additionally, a comprehensive breakdown of a study on high-dose Semaglutide treatments for diabetes and obesity discusses the balance between increased weight loss and rising side effects. The discussion shifts to industry challenges, like Hims Inc.'s layoffs due to FDA crackdowns on compounded GLP-1s, and a new ISSA course designed to help athletic trainers support GLP-1 users. Also covered is the intense industry debate over compounded medications, a major court ruling in India impacting Semaglutide sales, and competitive developments in China's obesity treatment market. The episode concludes with highlights of an innovative partnership between Nxtera Pharma and Eli Lilly aiming at new metabolic treatments. The hosts encourage viewers to stay informed and share personal insights on navigating GLP-1 treatments. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:04 Eli Lilly's Latest Data and Innovations 05:21 High Dose Semaglutide Study Insights 10:14 Hims Layoffs and FDA Crackdown 11:51 New Training Course for GLP-1 Trainers 13:58 Compounded Medications Debate 17:08 Legal Battles and Market Dynamics in India 20:16 NextEra Pharma and Eli Lilly Partnership 21:52 Upcoming Competition in China's GLP-1 Market 24:25 Conclusion and Final Thoughts

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1 katori rice, 1 cup saute veggies with paneer & mexican herbs, 1 cup lentils ♦️Around 500 kcal, 20 g protein, 8 g fiber, 55g carbs ♦️ Note: This portion size suits me, my routine and my goals, your portion size can likely differ :) I am a clinical dietitian with more than 7 years of experience & the best way to ensure that you are rightly nourishing your body is - Balanced Eating & yes that is the right way for losing weight too! Also I have developed a love for sauté vegetables with different herbs! This one has mixed herbs, oregano, chilli flakes, black pepper & some garlic powder. I can help you lose weight & improve your health by a sustainable diet plan, Comment NUTRITION know more about it 🫶🏻 Save this & follow for more such balanced meal inspiration ✅ #enrichlifestylewithurvi #clinicaldietitian #balancedeating #lifestylemanagement #onlinedietitian #weightlossdiet #healthyrecipeideas

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The ketogenic diet has gained immense popularity in recent years for its ability to promote weight loss and improve overall health. By restricting carbohydrates and increasing healthy fats, the body enters a state of ketosis, where it burns fat for fuel instead of glucose. While the benefits of the keto diet are well-documented, many people find it challenging to reach and maintain ketosis on their own. This is where Keto BHB comes in, a supplement that claims to help people achieve ketosis more easily and effectively.

What is Keto BHB?

Keto BHB is a supplement that contains exogenous ketones, specifically Beta-Hydroxybutyrate (BHB). Exogenous ketones are ketones that are consumed from an external source, as opposed to being produced naturally by the body. BHB is one of the three ketone bodies that are produced during ketosis, and it is known for its ability to provide the body with a quick and efficient source of energy. By taking Keto BHB, users can boost their blood ketone levels and enter a state of ketosis more quickly.

In addition to BHB, Keto BHB may also contain other ingredients such as electrolytes, MCT oil, and vitamins to support overall health and well-being while following a ketogenic diet. These additional ingredients can help provide energy, improve mental focus, and prevent common side effects of the keto flu, such as fatigue and brain fog.

How Does Keto BHB Work?

When you consume Keto BHB, the BHB ketones are rapidly absorbed into the bloodstream and delivered to the cells for energy production. Once in the cells, BHB is converted into acetyl-CoA, which then enters the citric acid cycle to produce ATP, the body’s primary source of energy. By providing the body with an alternative source of energy, Keto BHB helps shift the metabolism from glucose to fat, promoting fat burning and weight loss.

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Moreover, by increasing blood ketone levels, Keto BHB can help suppress appetite and reduce cravings, making it easier to stick to a ketogenic diet and achieve weight loss goals. This appetite-suppressing effect is particularly beneficial for those who struggle with overeating or emotional eating, as it can help control hunger and promote a feeling of satiety.

Benefits of Keto BHB

One of the main benefits of Keto BHB is its ability to accelerate the process of ketosis and help users reach a state of fat burning more quickly. This can be especially helpful for those who are new to the keto diet and may struggle to deplete their glycogen stores and transition to using fat for fuel. By taking Keto BHB, users can experience the benefits of ketosis, such as increased energy, mental clarity, and weight loss, without having to strictly adhere to a low-carb diet.

Additionally, Keto BHB can help alleviate some of the common side effects of the keto flu, such as fatigue, headaches, and muscle cramps. The electrolytes and other nutrients in Keto BHB can help replenish essential minerals lost during ketosis, ensuring that the body stays properly hydrated and nourished while following a ketogenic diet.

Is Keto BHB Safe?

As with any supplement, it’s essential to consult with a healthcare provider before adding Keto BHB to your daily regimen, especially if you have any underlying medical conditions or are taking medications. While Keto BHB is generally considered safe for most people, some individuals may experience side effects such as digestive issues, headaches, or insomnia. It’s essential to start with a low dose of Keto BHB and gradually increase as needed to minimize any potential adverse effects.

Furthermore, it’s crucial to use Keto BHB in conjunction with a healthy diet and regular exercise routine to maximize its benefits and promote long-term weight loss and overall well-being. While Keto BHB can help kickstart ketosis and accelerate fat burning, it’s not a magic pill for weight loss. Consistency and commitment to a healthy lifestyle are key to seeing lasting results with Keto BHB and the ketogenic diet.

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