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Watch The Full Episode Here: https://youtu.be/br4TSVzCv50 Listen To The Full Episode On Spotify: https://open.spotify.com/episode/7tk43nVbEIEEprzXNL2S5t?si=7c3f30862d5b4135 🎧 Listen To #TheRanveerShow On Spotify: https://open.spotify.com/show/6ZcvVBPQ2ToLXEWVbaw59P ✅ Subscribe To Our Other YouTube Channels:- BeerBiceps (English Channel): https://www.youtube.com/c/BeerBicepsOfficial Ranveer Allahbadia (Hindi Channel): https://www.youtube.com/c/RanveerAllahbadia TRS Clips हिंदी (Hindi Podcast Highlights): https://www.youtube.com/channel/UCzdMY6Qsv9CrsNCPgtZlrIw BeerBiceps Shorts (English Shorts): https://www.youtube.com/channel/UCzBvAIHPZ_Y7chhoN5ebv_A Ranveer Allahbadia Shorts (Hindi Shorts): https://www.youtube.com/channel/UCnYiTCfI0KIKRv6nxj99Ehg BigBrainco. : https://www.youtube.com/channel/UCDHQsUdSQE3p4i5vCXB7uFA BigBrainco. Shorts : https://www.youtube.com/channel/UC61gI6x3l4FZK9PQS_6G9nQ This man needs no introduction. One of the top health and fitness coaches in India who has also mentored some of the top celebrities in Bollywood is Luke Coutinho. Luke has been on the show previously, some of our most loved episodes. We previously spoke about fitness & food habits, drugs & psychedelics, and warrior mentality. Luke talks about the real difference between being fat and bloated, and how to get rid of bloating - causes and solutions. #bloating #1462 INSTAGRAM : @beerbiceps https://www.instagram.com/beerbiceps/ FACEBOOK : @beerbiceps https://www.facebook.com/beerbiceps/ TWITTER : @beerbicepsguy https://twitter.com/BeerBicepsGuy LINKEDIN : @beerbiceps https://www.linkedin.com/in/BeerBiceps TELEGRAM: @beerbicepsguy https://t.me/beerbicepsguy SNAPCHAT: @beerbicepsguy ---------------------------------------------- About : TRS Clips is a collection of SHORT CLIPS from The Ranveer Show podcast. The Ranveer Show by Ranveer Allahbadia has grown to become India's biggest and smartest English Podcast on audio platforms. Hope you enjoy our latest knowledge-fueled videos from the BeerBiceps team.

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🎙️EP282｜善纖達，猛健樂，所有GLP-1受體促效劑：減重、控糖、護心腎？從藥物比較到臨床應用全解析 — 📌主題亮點： • ​ GLP-1受體促效劑的作用機轉是什麼？為何能兼顧控糖與體重管理？ • ​ Tirzepatide、Semaglutide、Liraglutide 怎麼選？療效與副作用比較一次看懂 • ​ 台灣健保給付限制、仿單外使用、心腎保護證據，全方位解析臨床現況 — 🔍內容解析： 本集重點： GLP-1受體促效劑（Glucagon-like peptide-1 receptor agonists, GLP-1 RAs）是目前糖尿病與肥胖症領域中最受矚目的藥物類別之一。這類藥物最初設計目的是控制第二型糖尿病血糖，但其延緩胃排空與降低食慾的機制，逐漸展現出優異的體重控制效果，成為減重治療的重要選項。 本集將全面比較目前臨床上常見的 GLP-1 RAs，包括 Semaglutide、Liraglutide、Dulaglutide、Exenatide、Tirzepatide 等，從作用機制、臨床療效、安全性，到心腎保護與健保給付現況，帶你掌握這波醫藥創新的核心。 — 🧩主題分段解析： — 🧬 GLP-1作用機轉：多重代謝效應的關鍵介質 GLP-1 是人體腸道於進食後釋放的一種腸泌素，具有多重生理功能： • ​ 刺激胰島素分泌（在高血糖狀態下） • ​ 抑制昇糖素分泌 • ​ 延緩胃排空，增加飽足感 • ​ 對中樞神經產生抑制食慾作用 GLP-1受體促效劑則是模擬這一生理訊號的藥物。由於天然 GLP-1 在體內迅速被 DPP-4 分解，因此這類藥物皆經修飾以延長半衰期，使其可每日或每週注射。 ⸻ 🩺 臨床療效比較：控糖與體重減輕雙重奏 根據大型隨機試驗與統合分析，GLP-1 RAs 在控制血糖（HbA1c）與體重管理上皆展現出顯著成效。 📌 各藥物臨床成效對比： 藥物名稱 HbA1c 降幅 體重減輕效果 使用頻率 核准適應症 Semaglutide -1.4 ~ -1.9% -6~15% 每週1次 第2型糖尿病、肥胖（國際核准） Tirzepatide -2.0 ~ -2.4% -10~20% 每週1次 第2型糖尿病（減重待核准） Liraglutide -1.0 ~ -1.5% -5~8% 每日1次 糖尿病、肥胖（Saxenda商品名） Dulaglutide -0.7 ~ -1.5% -2~5% 每週1次 糖尿病 Exenatide -0.8 ~ -1.0% -2~3% 每週或每日 糖尿病 其中 Tirzepatide 屬於 GIP/GLP-1 雙重受體促效劑，在 SURMOUNT 與 SURPASS 試驗中展現出前所未有的血糖控制與減重表現，有望改寫治療標準。 — 💖 心血管與腎臟保護：超越控糖的新方向 越來越多研究指出，GLP-1 RAs 除了降血糖與減重，也具有心腎保護效果，這點在糖尿病病人族群中特別重要。 📌 心血管研究亮點： • ​ LEADER試驗（Liraglutide）： 減少 MACE（重大心血管事件）13% • ​ SUSTAIN-6（Semaglutide）： 顯著降低心血管事件與腎功能惡化風險 • ​ REWIND（Dulaglutide）： 在高風險群中降低中風與心臟衰竭住院率 腎臟方面，GLP-1 RAs 可延緩 eGFR 下降速度、降低蛋白尿發生，與 SGLT2i 一同被納入 CKD 病患用藥建議中（KDIGO 2022）。 — ⚠️ 常見副作用與風險考量 GLP-1 類藥物最常見的不良反應是胃腸道不適： • ​ 噁心、嘔吐、腹瀉（劑量上升時尤明顯） • ​ 厭食、味覺改變 此外，也需注意以下安全議題： 1. ​ 胰臟炎風險： 少見但需警惕，特別是胰臟病史者 2. ​ 甲狀腺 C 細胞腫瘤： 動物實驗有顯示，故有甲狀腺腫瘤病史者應避免使用 3. ​ 低血糖風險： 單用風險低，但與 SU 類或胰島素併用時需留意 4. ​ 腎功能不全： 輕中度 CKD 可使用，但末期腎病需個別評估 目前各大指引皆建議以「緩慢劑量上升」的方式起始治療，以改善耐受性。 — 📋 台灣市場與健保現況：法規限制與臨床建議 雖然 GLP-1 RAs 在國際間已被廣泛應用於肥胖與代謝症候群治療，但在台灣市場仍受到幾項限制： 1. ​ 健保給付範圍有限： 僅核准用於第二型糖尿病患者，且常須 HbA1c ＞ 7.5% 且合併肥胖者 2. ​ 體重管理為仿單外使用： 減重用途目前無正式健保核准 3. ​ 高藥價問題： 自費族群常成經濟負擔障礙 4. ​ 專科醫師使用限制： 多數藥品須由內分泌科或新陳代謝科開立 根據 NHIA 公告，目前 Semaglutide（Ozempic）與 Liraglutide（Victoza）皆列為給付藥品，但需符合嚴格條件。 — 🚶‍♀️ 臨床應用建議：如何選擇最適合的 GLP-1 受體促效劑？ 臨床選擇應考慮以下因素： • ​ 目標： 控糖為主或減重為主？ • ​ 用藥頻率接受度： 每日注射 vs 每週注射 • ​ 腎功能狀況 • ​ 副作用耐受性 • ​ 病患偏好與經濟狀況 📌舉例： • ​ 對減重有高度期待者：Tirzepatide ＞ Semaglutide ＞ Liraglutide • ​ CKD早期患者：Semaglutide、Dulaglutide皆可考慮 • ​ 容易噁心者：可考慮低劑量起始且選擇耐受性較佳者如 Dulaglutide • ​ 自費負擔有限者：評估 Liraglutide 台灣仿單內使用是否適用 — 📣負責任的行動： GLP-1 受體促效劑不只是「減重神藥」，而是結合代謝改善、心腎保護與控糖成效的複合型療法。醫師在使用前應評估患者整體代謝風險、心血管病史與用藥習慣，避免將此藥物視為「萬靈丹」。 病患亦應接受完整衛教，了解可能副作用與正確使用方法，避免自行停藥或過度依賴。 — 📚熱門關鍵字： #GLP1受體促效劑 #Semaglutide #Ozempic #Tirzepatide #Mounjaro #Liraglutide #Saxenda #減重藥物 #糖尿病治療 #心血管保護 #腎臟保護 #胰島素促進劑 #胃排空延緩 #體重管理 #胃腸道副作用 #甲狀腺C細胞腫瘤 #台灣健保給付 #仿單外使用 #慢性腎病新療法 #糖尿病臨床指引 — 🎤主講人資訊： Dr.Happy Human Plumber｜心血管知識推廣者 擅長將複雜代謝藥物與心腎內科整合知識，轉化為清晰易懂的內容，關注台灣臨床處方趨勢與全球新藥發展，致力於提升醫病雙方的治療選擇品質。 Powered by Firstory Hosting (https://firstory.me/zh)

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One of the most intriguing pitches on the Shark Tank episode was a line of keto meal delivery kits that promised to make sticking to the diet easier and more convenient for busy individuals. The entrepreneur behind the product shared compelling testimonials from customers who had successfully lost weight and improved their health by following the keto diet with the help of these meals. The sharks were impressed by the potential market for such a product and engaged in a heated debate over the merits of the keto diet.

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Another entrepreneur on the episode presented a line of keto supplements designed to enhance the effects of the diet and help individuals reach ketosis faster. These supplements claimed to provide essential nutrients and promote fat burning, but the sharks questioned the necessity of such products when following a well-rounded keto diet. The entrepreneur cited studies and research supporting the benefits of their supplements, but faced skepticism from the sharks who were wary of the supplement industry.

During the episode, the sharks expressed concern about the potential side effects of the keto diet, including nutrient deficiencies and increased cholesterol levels. They questioned the long-term sustainability of the diet and whether it was truly the most effective way to achieve weight loss and improve health. The entrepreneurs defended the keto diet, citing its ability to regulate blood sugar levels, reduce inflammation, and increase energy levels. The debate highlighted the ongoing controversy surrounding the keto diet and the need for more research and understanding of its effects on the body.

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Overall, the Shark Tank episode on the keto diet shed light on the growing popularity and controversy surrounding this eating plan. While some viewers were inspired to try the keto diet and explore keto-friendly products, others were left with lingering questions about its safety and efficacy. The episode served as a reminder of the importance of informed decision-making when it comes to diet and nutrition, and the need for more research and education on the impact of the keto diet on overall health.

In conclusion, the Shark Tank episode featuring products and services related to the keto diet offered a fascinating look into the world of ketogenic eating and sparked important discussions about its benefits and drawbacks. Whether you’re a staunch supporter of the keto diet or a skeptic, the episode provided valuable insight into the current state of the diet industry and the ongoing quest for optimal health and wellness.

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🔥 Are you actually losing fat on GLP-1, or is it just water weight? 🔥 You step on the scale, and the numbers are dropping—but wait! Is this real fat loss, or just temporary water weight? Many people on GLP-1 medications like Ozempic, Wegovy, and Mounjaro see quick results, but not all weight loss is the same. If you’re wondering whether your progress is sustainable fat loss or just water fluctuations, this video breaks it all down for you! Hey everyone, welcome back to NNENNA ON GLP-1! If you’re new here, I’m Nnenna, and I share real experiences, science-backed strategies, and no-nonsense advice to help you navigate your GLP-1 journey. If that sounds like something you need, hit that subscribe button and let’s dive into today’s topic! 🔬 Fat Loss vs. Water Weight: What’s the Difference? Water weight is fluid retention in your body, which can change daily based on hydration, sodium intake, hormones, and stress. It’s why you can gain or lose 2-5 pounds overnight without changing your diet. Fat loss, on the other hand, happens when your body burns stored fat for energy, which is a slower, more permanent process. This is where real body transformation happens! A lot of people lose weight quickly when starting GLP-1, and while that’s exciting, much of that initial drop is water weight, not fat. Here’s why: ✅ GLP-1 reduces appetite, leading to lower sodium intake and less water retention ✅ Carbs hold water (1 gram of glycogen = 3 grams of water) ✅ Eating fewer processed foods means less bloating and sodium-related water retention ✅ Hydration levels change, causing temporary weight fluctuations 💡 Signs You’re Losing Fat (Not Just Water Weight!) 🔹 Slow & Steady Scale Drops – Fat loss happens at 1-2 lbs per week, while water weight fluctuates daily. 🔹 Clothes Fit Differently – Even if the scale doesn’t move, body composition changes mean looser clothes. 🔹 More Energy, Less Bloating – Fat loss improves metabolism, while water loss can make you feel drained. 🔹 Lower Body Fat Percentage – Use scans or calipers to track true fat loss. 🔥 How to Ensure Real Fat Loss on GLP-1 💪 Prioritize Protein: Aim for 80-100g daily to maintain muscle while losing fat. 🏋️‍♀️ Strength Train: Cardio is great, but lifting weights preserves muscle and keeps your metabolism high. 💦 Drink More Water: Hydration reduces bloating and helps your body shed excess fluids naturally. 🥗 Eat Whole Foods: Cut down on processed foods & sodium to minimize water retention. 📏 Focus on Measurements & Progress Photos: The scale isn’t the only indicator of success!

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