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Partial or biased agonism to improve GLP-1 receptor agonist properties by Ben Jones, Clinical Senior Lecturer Imperial College London I will discuss our work aiming to understand whether the therapeutic properties and side effect profile of GLP-1R agonism can be improved by refining intracellular signalling properties. Ben Jones is a Clinical Senior Lecturer within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focused on the translational pharmacology of G protein coupled receptors in metabolic disease. He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor. After completing clinical training in 2020 he has was awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF), and subsequently an MRC Clinician Scientist Fellowship. Current work aims to establish the mechanism of action of β€œbiased” incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity. https://thelongevityforum.com

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Welcome to Keto Diet 101: Demystifying the Ketogenic Diet for Beginners and Its Weight Loss Benefits. This video breaks down what the keto diet really is, how it helps your body burn fat efficiently, and why so many people are turning to it for sustainable weight loss and better health. If you're just starting out or curious about whether keto is right for you, this guide offers the clarity and motivation you need. #ketodiet #ketoweightloss #keto101 See also: https://youtu.be/rk1ecgC02aw

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