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Holly Lofton, MD, an obesity expert at NYU Langone Health, discusses the differences between GLP-1 agonists for weight loss and glycemic control. https://www.medscape.com/viewarticle/995911?src=soc_yt -TRANSCRIPT- I'm Dr Holly Lofton, clinical associate professor of surgery and medicine at NYU Langone Health, and I direct the medical weight management program. My practice is solely based on chronic weight management for adults. Today I'll talk about the various doses of GLP-1 agonists that you may prescribe to your patients. Being that this is based around weight management, I'll start with the weight management medications, the first of which is Saxenda. This is liraglutide 3 mg for chronic weight management. The studies that were done with this medication were intended to get the patient to the 3-mg dosing, which is what's prescribed for weight management, and not the 1.8-mg dosing which is prescribed for type 2 diabetes. However, you may deliver different doses to your patients depending on your goal. You see that this makes a lot of clicking noise. When the patient starts Saxenda and has their pen, there will be this clear fluid. It's important to remind them that this is a multiuse pen and that they should use it over and over again until it's empty. This medication has various doses in the same pen. You want to increase weekly as long as the patient is tolerating it. And by that, I mean not having significant side effects such as nausea, constipation, or other stool changes. When a patient receives the pen, it will start with 0. In the first week, we do 0.6 mg daily. The next week we do 1.2 mg daily. The third week we do 1.8 mg daily. The next week we do 2.4 mg daily, and then the goal is to get the patient to 3 mg, which is the maintenance dose. Ideally, the patient would stay there for their chronic weight management. However, if a patient can't tolerate the dose, you can also have them go to a lower dose for 7 more days and try again. Wegovy, which is semaglutide 2.4 mg, is also prescribed for chronic weight management. This is a single-use cartridge, so the pen will deliver only the dose that you prescribe to the patient. This as well is intended to increase monthly as long as the patient is tolerating it and not having too many significant GI side effects such as nausea, constipation, or loose stool. With this pen, the doses are 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg. You increase it monthly or every 4 weeks, depending on the patient tolerance. However, if a patient is not able to tolerate the highest dose, you can prescribe the maximally tolerated dose for that patient. The next new GLP-1 I'll talk about is Ozempic [semaglutide] prescribed for type 2 diabetes. The goals of titrating this medication really depend more on your patient's glycemic control, as this is used for glycemic management. Here we have the red labels and big pen, and this delivers either 0.25 mg or 0.5 mg. The recommendation for this medication is to use 0.25 mg for 4 weeks. Assess the patient's glycemic control, and if needed, increase to 0.5 mg after 4 weeks. Again, this pen delivers either 0.25 mg or 0.5 mg only. This blue-green–label Ozempic [semaglutide] delivers 1-mg dosing, so when your patient turns this one all the way to the end, the only number they will see will be 1. If your patient does not have optimal glycemic control with the lower doses, a 1-mg pen can be prescribed and the patient can continue on that, optimizing their glucose, or you can increase to a 2-mg pen [yellow label], which delivers only 2 mg. This is a single-use cartridge for Trulicity [dulaglutide]. The various doses of Trulicity are 0.75 mg, 1.5 mg, 3 mg, and 4.5 mg. This pen will deliver only the dose that's prescribed, and you can titrate up to optimize glycemic control for your patient. The higher the dose, the better the improvement in glucose and hemoglobin A1c. This is the pen for Mounjaro, which is tirzepatide. At the time of this recording, this medication is intended for type 2 diabetes management. It's a single-use cartridge, and the different doses vary from 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, to the highest dose, 15 mg. Again, this should be titrated to optimize glycemic control for your patient, and you can increase or decrease the dose based on the patient's tolerance. https://www.medscape.com/viewarticle/995911?src=soc_yt

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Welcome to our comprehensive analysis and user feedback review of Platinum Label Keto ACV Gummies. In recent years, the popularity of apple cider vinegar (ACV) gummies has soared due to their potential health benefits, including weight loss support, improved digestion, and better blood sugar regulation. Platinum Label Keto ACV Gummies are a premium blend of ACV and other natural ingredients designed to provide these benefits in a convenient and delicious form.

Ingredients and Formulation:

Platinum Label Keto ACV Gummies contain a potent blend of apple cider vinegar, vitamin B6, vitamin B12, and folic acid. These ingredients work together to support weight management, boost energy levels, and improve overall health. The gummies are also free from artificial colors, flavors, and preservatives, making them a safe and effective supplement for daily use.

The apple cider vinegar used in Platinum Label Keto ACV Gummies is sourced from organic, non-GMO apples and contains the “mother,” which is a naturally occurring probiotic that enhances the benefits of ACV. This ensures that you are getting the full nutritional value of apple cider vinegar in each tasty gummy.

Each serving of Platinum Label Keto ACV Gummies provides 500mg of apple cider vinegar, which is equivalent to one liquid teaspoon. This dosage is ideal for reaping the benefits of ACV without the overpowering taste and smell that often accompany liquid vinegar. The gummies are also flavored with natural fruit juices to enhance their taste and make them enjoyable to consume.

Benefits and Efficacy:

Users of Platinum Label Keto ACV Gummies have reported a variety of benefits, including improved digestion, increased energy levels, and better weight management. The gummies are also said to help curb cravings and support healthy blood sugar levels, making them a valuable tool for those looking to improve their overall health and well-being.

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Many users have also praised the convenience of Platinum Label Keto ACV Gummies, noting that they are easy to incorporate into their daily routine and are more palatable than traditional apple cider vinegar. Some users have even reported that the gummies have helped them achieve their weight loss goals and improve their overall quality of life.

Platinum Label Keto ACV Gummies are manufactured in a GMP-certified facility in the USA to ensure quality and potency. The gummies are also third-party tested for purity and safety, giving users peace of mind that they are consuming a premium product that meets the highest standards of quality and efficacy.

User Feedback and Reviews:

Feedback from users of Platinum Label Keto ACV Gummies has been overwhelmingly positive, with many customers praising the gummies for their effectiveness and great taste. Users have reported noticeable improvements in their digestion, energy levels, and weight management after incorporating the gummies into their daily routine.

Some users have also shared their success stories with Platinum Label Keto ACV Gummies, noting that they have experienced significant weight loss and improved overall health since starting to take the gummies. Many users appreciate the convenience of the gummies and the fact that they can enjoy the benefits of apple cider vinegar without the unpleasant taste.

Overall, Platinum Label Keto ACV Gummies have received high marks from users for their quality, efficacy, and taste. Many customers have said that they will continue to use the gummies as part of their daily health regimen and recommend them to others looking to improve their health and well-being.

Conclusion:

In conclusion, Platinum Label Keto ACV Gummies offer a convenient and delicious way to reap the benefits of apple cider vinegar. With their potent blend of natural ingredients and positive user feedback, these gummies are a valuable supplement for anyone looking to improve their digestion, energy levels, and weight management. Give Platinum Label Keto ACV Gummies a try today and experience the many benefits for yourself!

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