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One thing I forgot to mention in this video is the fact that you can scale up or down depending on your fitness level. Don't take the progressions as a rule; you want to match this towards your fitness level to make sure it's challenging enough for you to get the most out of it. Here's the walking workout mentioned in the video: https://dango.kit.com/workout-to-lose-belly-fat Work with me to get lean and optimize your body: https://www.dango.co/privatecoaching Join 390,000 high performers on my newsletter (free): https://www.dango.co/newsletter2 ––– Free Protocols ––– High Performance Sleep Protocol (free): dango.ck.page/sleepreport Complete Guide to Being Metabolically Healthy: https://dango.kit.com/guide-to-becoming-metabolically-healthy Complete Guide To Eliminating Visceral Fat: https://dango.kit.com/guide-to-losing-visceral-fat Build muscle in 33 minutes: https://dango.kit.com/myoreps ––– Paid Courses & Programs ––– Lean Body 90: https://www.dango.co/lean-body-90 6 Minute Superhuman: https://www.dango.co/6-minute-superhuman ––– More Content ––– ––– Chapters ––– 00:00 Intro 00:46 Endurance Running Sucks 01:57 Walking is a Superpower 03:29 30m Pyramid Workout 06:54 Benefits of Walking

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Semaglutide is a medication that has been making waves in the weight loss industry due to its proven effectiveness in helping individuals shed unwanted pounds. Approved by the FDA for weight management in 2021, semaglutide works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. This hormone is naturally released in response to food intake and helps regulate blood sugar levels, insulin production, and feelings of satiety.

Semaglutide Mechanism of Action Explained

When semaglutide is injected into the body, it binds to GLP-1 receptors on cells in the pancreas, brain, and other organs. This activation of GLP-1 receptors leads to a variety of effects that work together to promote weight loss. One key mechanism of action is the inhibition of gastric emptying, which delays the passage of food from the stomach to the intestines. This delay helps individuals feel fuller for longer periods, reducing overall caloric intake.

Another important effect of semaglutide is its ability to regulate appetite and reduce cravings for high-calorie foods. By acting on the brain’s appetite centers, semaglutide helps individuals make healthier food choices and resist the temptation to overeat. Additionally, semaglutide has been shown to increase feelings of satiety after meals, further supporting weight loss efforts.

GLP-1 Receptor Activation

GLP-1 receptor activation by semaglutide also plays a role in regulating blood sugar levels and insulin sensitivity. By mimicking the effects of GLP-1, semaglutide helps control glucose production in the liver, promote insulin secretion from the pancreas, and improve insulin sensitivity in peripheral tissues. These effects are beneficial for individuals with type 2 diabetes, a condition often associated with obesity.

Furthermore, semaglutide has been shown to have effects on energy expenditure, or the number of calories the body burns at rest. By stimulating the production of brown adipose tissue, a type of fat that burns calories to generate heat, semaglutide helps boost metabolism and promote weight loss. This increase in energy expenditure can further enhance the results of a healthy diet and exercise regimen.

Potential Side Effects and Considerations

While semaglutide has shown significant promise as a weight loss medication, it is not without potential side effects and considerations. Common side effects of semaglutide may include nausea, vomiting, diarrhea, and constipation. These gastrointestinal symptoms typically improve over time as the body adjusts to the medication. Additionally, semaglutide may interact with other medications or have contraindications for individuals with certain medical conditions.

It is important for individuals considering semaglutide for weight loss to discuss the potential risks and benefits with their healthcare provider. Regular monitoring and follow-up appointments may be necessary to ensure the safe and effective use of semaglutide. Overall, semaglutide offers a promising option for individuals struggling to lose weight and improve their overall health.

Conclusion

In conclusion, semaglutide works by mimicking the effects of GLP-1 in the body, leading to benefits such as reduced appetite, delayed gastric emptying, improved insulin sensitivity, and increased energy expenditure. These mechanisms of action support weight loss efforts and make semaglutide a valuable tool for individuals looking to achieve their weight loss goals. While potential side effects and considerations exist, the overall benefits of semaglutide for weight management are substantial.

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We all know what hunger feels like, but what happens to our bodies if we stop eating? What exactly is the science behind starvation? Is The North Korean Government To Blame For Starving Citizens? ►►►►http://bit.ly/1S0wnJt Sign Up For The TestTube Newsletter Here ►►►► http://bit.ly/1myXbFG Read More: How Long Can a Person Survive Without Food? http://www.scientificamerican.com/article/how-long-can-a-person-sur/ “The duration of survival without food is greatly influenced by factors such as body weight, genetic variation, other health considerations and, most importantly, the presence or absence of dehydration. For total starvation in healthy individuals receiving adequate hydration, reliable data on survival are hard to obtain.” The Psychology of Hunger http://www.apa.org/monitor/2013/10/hunger.aspx “In November 1944, 36 young men took up residence in the corridors and rooms of the University of Minnesota football stadium. They were not members of the football team. Rather, they were volunteers preparing for a nearly yearlong experiment on the psychological and physiological effects of starvation. Known as the Minnesota Starvation Experiment, the study was a project of the newly established Laboratory of Physiological Hygiene at the University of Minnesota, an interdisciplinary research institution with an emphasis on nutrition and human biology.” Brain Foods: The Effects of Nutrients on Brain Function http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805706/ “It has long been suspected that the relative abundance of specific nutrients can affect cognitive processes and emotions. Newly described influences of dietary factors on neuronal function and synaptic plasticity have revealed some of the vital mechanisms that are responsible for the action of diet on brain health and mental function. Several gut hormones that can enter the brain, or that are produced in the brain itself, influence cognitive ability.” ____________________ DNews is dedicated to satisfying your curiosity and to bringing you mind-bending stories & perspectives you won't find anywhere else! New videos twice daily. Watch More DNews on TestTube http://testtube.com/dnews Subscribe now! http://www.youtube.com/subscription_center?add_user=dnewschannel DNews on Twitter http://twitter.com/dnews Trace Dominguez on Twitter https://twitter.com/tracedominguez Lissette Padilla on Twitter https://twitter.com/lizzette DNews on Facebook https://facebook.com/DiscoveryNews DNews on Google+ http://gplus.to/dnews Discovery News http://discoverynews.com Download the TestTube App: http://testu.be/1ndmmMq Sign Up For The TestTube Mailing List: http://dne.ws/1McUJdm

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While looking over the research on the effect of GLP-1 receptor agonists on alcohol consumption, I stumbled across a recent and _really_ interesting paper on how that class of drugs affects sensation. It's "Glp-1 Receptor Agonists Significantly Impair Taste Function" by Rafa Khan and Richard L. Doty in _Physiology & Behavior_ Vol. 291 (published version at https://www.sciencedirect.com/science/article/abs/pii/S003193842400341X and white paper version at https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4953499 ). Don't necessarily take that title on its face, as the details are super important and incredibly interesting and maybe not as dire as you'd think. And, well, I felt like it would be a good use of my platform to discuss all of this. So that's what we're doing today, talking about this hugely consequential new class of drugs - Wegovy/Ozempic (semaglutide), Mounjaro (tirzepatide, although that's also a GIP), and whatever else is going to be out there - with an eye towards spirits nerdery. First I broadly discuss the history and basic mechanisms of these drugs, with a brief detour into side effects and what I would consider to be "best practices" in using them for weight loss purposes. (N.b., I don't get into treatment for type 2 diabetes and that's another set of concerns, also I am not a doctor and please consult a medical professional for all this etc..) And then I discuss the paper above. And... well, it's complicated. Based on their results I think the main takeaway is that while GLP-1 agonists seem to have very good odds of degrading your sense of taste, there's also pretty good odds that you won't actually notice. 🤷 Extra special thanks to my Different Spirits on Patreon (https://www.patreon.com/differentspirits), who got this video first - Eric Amig Anthony Darcy Bean Jamie Brown Kingsbury bushcraft William Christopher Clematis Rob D Liam Davitt Joe Devine Samuel Dose Stephen Eckert eon Ingmar nine Steve Frazee Ian Gendler Solomon Grundy John Halliday Alex Hurd Trevor Jarrait Jonathan Lestingi Kyaru Ariel Mserious Craig Nielsen Jason Newquist No Thanks Chris Rhodes Randy Rice RumSquirrel Gordon W Zach W

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