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(https://isappscience.org/wp-content/uploads/2025/07/Greiner-cover.png) This episode features Dr. Thomas Greiner PhD from the University of Gothenburg (Sweden), speaking about the various functions of GLP-1 in the gut, and the role of gut microbes in GLP-1 production, with ultimate effects on host health. He noted that GLP-1 is produced by enteroendocrine cells called L-cells, both in the small intestine and the colon. These cells respond to nutrients and microbially-produced short-chain fatty acids, but responses differ between the small intestine and colon, leading Dr. Greiner to investigate the different functions of GLP-1 at these two sites. Using germ-free mice and other models, Dr. Greiner has developed a hypothesis that the function of GLP-1 in the small intestine is to improve insulin secretion postprandially, whereas the functions of GLP-1 in the colon are to allow for increased energy intake (in a situation of energy deficiency), dampen inflammation, and protect local tissues. He and his colleagues are taking two different approaches in aiming to improve metabolic health in humans: finding inhibitors of bacterial enzymes to decrease production of a harmful molecule produced by bacteria; and a probiotic approach of administering butyrate-producing bacteria. With the latter approach, the sensitivity of the bacteria to oxygen is a problem to overcome, but their group has evolved a bacterial strain to tolerate some oxygen, with the idea of testing it as a probiotic. Episode abbreviations and links: • Paper exploring the role of the gut microbiota in GLP-1 signaling: GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota (https://www.sciencedirect.com/science/article/pii/S2212877824000553?via%3Dihub) • Study on the functions of GLP-1 in the colon: Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(13)00365-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS193131281300365X%3Fshowall%3Dtrue) • Bäckhed Lab Instagram account: @backhed_lab (https://www.instagram.com/backhed_lab?igsh=MWdpdmlndDAxOWFjag==) About Dr. Thomas Greiner PhD: Thomas Greiner is a medical scientist at the Wallenberg Laboratory, University of Gothenburg, with over 15 years of experience in functional genetics and metabolic research. His work focuses on the intricate interplay between gut microbiota, intestinal hormones such as GLP-1, and host metabolism. He has explored how microbial and hormonal signals influence energy balance, intestinal function, and the development of metabolic diseases. His research primarily uses molecular approaches in mouse models to investigate the role of microbial signals in metabolic disease and to uncover new functions of gut hormones in regulating intestinal physiology. Sign up (https://isappscience.org/for-scientists/news/isapp-newsletters/) for our monthly newsletter Follow us (https://isappscience.org/contact/) on LinkedIn, Bluesky, X, Facebook, Instagram, Threads The post Unraveling the functions of GLP-1 in the gut, with Dr. Thomas Greiner PhD (https://isappscience.org/episode-65-unraveling-the-functions-of-glp-1-in-the-gut/) appeared first on International Scientific Association for Probiotics and Prebiotics (ISAPP) (https://isappscience.org) .
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Jelly Roll shows off his 110lb weight loss as he poses with his wife Bunnie XO at the 2024 CMA Awards Jelly Roll showed off his 110lb weight loss as he posed with his wife Bunnie XO at the Country Music Association Awards this Wednesday. The 39-year-old recently detailed how he went from a tour culture of 'alcohol and drugs' to embracing physical fitness and healthier foods in an interview with People. Now, after overhauling his lifestyle and surpassing his goal of dropping 100lbs, the singer proudly displayed his new figure at this week's awards show. He and his wife were among the cavalcade of country music luminaries who flooded into Nashville's Bridgestone Arena for the event. Glowing with happiness, Jelly wore a simple short-sleeved top over a black t-shirt as he stood for a snap with Bunnie XO and songstress Megan Moroney. Jelly emphasized his trimmed-down figure in black when he hit the stage that evening to deliver a rendition of Believe, his song with Brooks + Dunn. He layered a black jacket over a matching top and trousers for the performance, as well as a cross in keeping with the song's religious theme. The Nashville native also took the stage that night alongside Keith Urban, with whom he performed the song Liar from Jelly's new album Beautifully Broken. In a stirring special effect, flames burst up behind the two men as they sang, throwing Jelly's figure into sharper relief. Jelly recently covered People and shared with the magazine that he believes he's dropped 60-70 pounds alone since beginning his Beautifully Broken tour in August. He's now opened up about how he stays fit on the road - a departure from the partying lifestyle he was once engrained in. The musician has reassessed his relationship with food - and is now reaping the benefits. 'The battle was with the food addiction, changing the way I’ve looked at food for the last 39 years,' he told the magazine. 'I’ve never had a healthy relationship with food, so that was the hard part. But once you get into that discipline and commitment, it’s like an avalanche. Once that little snowball started rolling, it was on its way.' Jelly said he plays basketball with his crew everyday on tour and he's made healthy eating and exercise a top priority during his tour. 'It’s cool because there was once a time in life that the culture I built on tour was the opposite. It revolved around alcohol and drugs,' he said. 'And now our tour culture is around good eating and around exercising and doing emotional check-ins with our crew every day.' #jellyroll #weightloss
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Dr. Friedman provides an important update on compounded GLP-1 medications, including tirzepatide and semaglutide. He discusses their uses, effectiveness, safety concerns, and what patients need to know about compounded versions. Learn how these medications work for weight loss and blood sugar control, potential risks, and differences from FDA-approved versions. Stay informed on the latest guidelines and best practices for using GLP-1 receptor agonists. Whether you're a patient or healthcare provider, this update will help you navigate compounded tirzepatide and semaglutide safely and effectively. Watch now to get Dr. Friedman’s expert insights on these popular medications.
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The ketogenic diet has been a popular choice for the last several years for people wanting to shed body fat and get in shape. Keto Body Tone is a supplement that supposedly helps to support the body to get into ketosis (fat for fuel instead of carbs). The product was featured on the television show Shark Tank, which prompted a renewed interest in the product’s benefits and effectiveness.
What is Keto Body Tone?
Available as diet pills, Keto Body Tone is a natural dietary supplement containing ingredients reportedly helping the body achieve the state of the ketosis. As reported on current medical research, ketosis is a metabolic state. It happens when the body burns fat instead of carbohydrates. This makes the diet a natural way to lose weight, while getting more energy and improving one’s mental clarity, according to Keto Body Tone official website. The supplement is alleged to help the body stay healthy during the transition to keto and make it easier for you to reach your weight loss goals.
The main ingredients (listed below) include BHB or Beta Hydroxybutyrate – an exogenous ketone that’s used by the body to create energy from fat. Keto Body Tone advises users to ‘increase their levels’, thus speeding up the movement towards ketosis. MCT oil produces ketones and Beta-hydroxybutyrate, which will reportedly provide your body with all the energy it needs to burn off extra fat. Exogenous ketones are the final ingredient. As the name suggests, these ketones are exogenously created; therefore ketosis can be achieved by just consuming these ingredients.
How does Keto Body Tone work?
In the body, ketosis, the state where fat is burned instead of carbohydrates for fuel, can facilitate quick weight loss and sustained energy levels. Due to its focus on healthy nutrition, Keto Body Tone actually supports the body’s own ability to come into ketosis. Without breaking down the substances responsible for energy production and fat metabolism, taking Keto Body Tone can put your body firmly on the right track to the ketogenic diet by providing it with the nutrients it needs most.
Keto Body Tone relies on BHB for the production of energy out of fat and is found to be the most significant ingredient in the Keto Body Tone formula. If you have ever attempted to reach ketosis with your body only, you know that it is very difficult to create enough ketones to initiate this process. This is where a supplement like Keto Body Tone steps in by boosting your body’s BHB levels. BHB is the magic ingredient that allows the body to produce fat into energy. By supplementing your body, you enhance its ability to metabolise fat and burn it for energy. If you want to experience an effective transition into ketosis, Keto Body Tone can help your body burn fat, get into ketosis and lose weight. Thanks to the additional ingredients that Keto Body Tone add to the mix, your energy level can remain consistent and constant throughout the day.
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Similarly, tender never has been sweeter: ‘Wow – what can I say . . . 28 pounds lighter!! Label me totally amazed, happy and satisfied!!!’ ‘Helped me get into keto faster. In 10 days I lost 11 lbs!!! I am so happy to have discovered this product. I had a long road ahead and this formula made it to where I could get into ketosis and make this diet work for me.’ ‘Amazing!! I just have to say that so far, I am loving the results! I have lost an amazing amount of weight, plus I have more energy.’
“For years I was never able to lose weight. Now, with Keto Body Tone, I not only have lost 15 pounds in only a few weeks, but also I feel the most energetic ever! I am extremely happy with it! Great product!” As there are only a few authenticated accounts to be found, it’s hard to be certain how many individuals benefitted from taking Keto Body Tone, but the general consensus seems to be very positive.
Should You Try Keto Body Tone?
If you’re considering a Keto Body Tone trial, we certainly advise a discussion with your healthcare provider, especially before you start any new supplement regimen. While alot of people who’ve spoken on the product have had positive experiences, it’s important to note that individual results will vary. And most importantly, Keto Body Tone is not a miracle pill, so take it as directed and you’ll need to also increase your physical activity and maintain an overall healthy diet to maximize your efforts.
All in all, Keto Body Tone may be the appropriate solution for people that are trying to get into ketosis and reach their goal of weight loss. The natural ingredients and the help to support the body when switching to a keto based diet is plenty of reasons why this is the right dietary supplement for many people. If you are thinking of trying to use Keto Body Tone, you should always take some time and research on it before deciding to try. Visit your healthcare professional and see if this is the proper solution for you.
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In recent years, the ketogenic diet has gained immense popularity for its potential to help individuals lose weight and improve their overall health. This high-fat, low-carb diet has been shown to be effective in promoting weight loss and increasing energy levels, leading many people to adopt this lifestyle. Along with the rise of the ketogenic diet, there has been a surge in the popularity of Facebook Keto Pills, which claim to help individuals achieve ketosis faster and easier. In this article, we will explore the insights and controversies surrounding the rise of Facebook Keto Pills.
The Science Behind Ketosis
Ketosis is a metabolic state in which the body burns fat for fuel instead of carbohydrates. By drastically reducing carbohydrate intake and increasing fat consumption, the body is forced to enter ketosis, leading to weight loss and other health benefits. This process typically takes a few days to a week to achieve through diet alone, but Facebook Keto Pills claim to expedite this process.
These pills usually contain a blend of exogenous ketones, which are ketones that are produced outside the body and ingested to induce ketosis. The theory is that by taking these pills, the body will enter ketosis more quickly, making it easier for individuals to stick to the ketogenic diet and see results faster. While some studies suggest that exogenous ketones can increase blood ketone levels and decrease appetite, more research is needed to fully understand their effectiveness and potential side effects.
The Rise of Facebook Keto Pills
With the increasing popularity of the ketogenic diet, it comes as no surprise that Facebook Keto Pills have become a hot commodity in the health and wellness industry. These pills are often marketed as a quick and convenient way to achieve ketosis without having to drastically change your diet or lifestyle. Many influencers and celebrities on social media platforms like Facebook have endorsed these pills, touting their benefits and effectiveness in helping them lose weight and improve their health.
However, the rise of Facebook Keto Pills has also sparked controversy and debate within the health community. Critics argue that these pills are not a magic solution for weight loss and may have negative side effects. Some experts warn that taking exogenous ketones in supplement form may not be safe for everyone, especially those with underlying health conditions or who are not following a ketogenic diet. Additionally, the long-term effects of these pills are still unknown, raising concerns about their potential impact on overall health.
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Another issue surrounding Facebook Keto Pills is the lack of regulation and oversight in the health supplement industry. Unlike prescription medications, dietary supplements are not subject to the same stringent testing and approval process by regulatory agencies, such as the Food and Drug Administration (FDA). This means that the safety and effectiveness of these pills are not always guaranteed, putting consumers at risk of potential harm.
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It is essential for individuals considering taking Facebook Keto Pills to do their research and consult with a healthcare professional before incorporating these supplements into their routine. While these pills may offer some benefits for those looking to jumpstart their ketogenic journey, they are not a substitute for a healthy diet and lifestyle. It is crucial to approach these supplements with caution and skepticism, as there is still much to learn about their long-term effects and safety.
The Future of Facebook Keto Pills
As the ketogenic diet continues to gain popularity, the demand for Facebook Keto Pills and similar supplements is likely to increase. While these pills may offer a convenient way to achieve ketosis and potentially see results faster, it is essential for consumers to approach them with caution and skepticism. More research is needed to fully understand the effects of exogenous ketones on the body and their long-term impact on health.
Ultimately, the rise of Facebook Keto Pills highlights the need for greater transparency and regulation in the health supplement industry. Consumers should be empowered to make informed decisions about their health and wellness, taking into account the potential risks and benefits of these products. By staying informed and consulting with healthcare professionals, individuals can navigate the complexities of the ketogenic diet and make choices that align with their health goals.
Overall, the rise of Facebook Keto Pills has both insights and controversies, shaping the way individuals approach the ketogenic diet and weight loss supplements. While these pills may offer some benefits for those looking to achieve ketosis faster, it is crucial to proceed with caution and prioritize safety above all else. By staying informed and making educated choices, individuals can harness the potential of the ketogenic diet and supplements to improve their health and well-being.
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