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Key Points Question Are glucagon-like peptide-1 receptor agonists semaglutide and liraglutide, which were originally introduced for the treatment of type 2 diabetes and are frequently prescribed due to their weight loss properties, associated with disproportionately increased reporting of suicidality? Findings This disproportionality analysis through the case-control design based on the World Health Organization global database collecting suspected adverse drug reactions, identified a disproportionality signal of suicidal ideation with semaglutide, which remained significant when comparing semaglutide with dapagliflozin and metformin and in the subgroup of patients with coreported use of antidepressants and benzodiazepines. Meaning A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification. Abstract Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained use primarily due to their weight-reduction effects, although a regulatory review was undertaken for potential suicidality concern. Objectives To evaluate potential signals for suicidal and self-injurious adverse drug reactions (ADRs) associated with the GLP-1 RAs semaglutide and liraglutide. Design, Setting, and Participants Disproportionality analysis through the case-control design using the World Health Organization (WHO) global database of suspected ADRs. Participants were clinical patients worldwide experiencing an ADR suspectedly attributable to semaglutide or liraglutide in the database from inception to August 30, 2023. Data were analyzed from September to December 2023. Exposure Treatment with semaglutide or liraglutide regardless of indication or treatment duration. Main Outcomes and Measures Reporting odds ratio (ROR) and the bayesian information component (IC) with 95% CIs were calculated as measures of disproportionate reporting of suicidal and self-injurious ADRs associated with semaglutide and liraglutide compared with all other medications. Sensitivity analyses were conducted including patients with coreported use of antidepressants and benzodiazepines and using dapagliflozin, metformin, and orlistat as comparators. A disproportionality signal was considered when the lower limits of the ROR and IC were above 1 and 0, respectively. Results A total of 107 (median [IQR] age 48 [40-56] years; 59 female patients [55%]) and 162 (median [IQR] age 47 [38-60] years; 100 female patients [61%]) cases of suicidal and/or self-injurious ADRs were reported between November 2000 and August 2023 with semaglutide and liraglutide, respectively. Significant disproportionality was detected only for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78), which remained significant in patients with coreported use of antidepressants (ROR, 4.45; 95% CI, 2.52-7.86; IC, 1.96; 95% CI, 0.98-2.63) and benzodiazepines (ROR, 4.07; 95% CI, 1.69-9.82; IC, 1.67; 95% CI, 0.11-2.65), when compared with dapagliflozin (ROR, 5.56; 95% CI, 3.23-9.60; IC, 0.70; 95% CI, 0.36-0.95), metformin (ROR, 3.86; 95% CI, 2.91-5.12; IC, 1.20; 95% CI, 0.94-1.53) and orlistat (ROR, 4.24; 95% CI, 2.69-6.69; IC, 0.70; 95% CI, 0.36-0.95). Conclusions and Relevance This study using the WHO database found a signal of semaglutide-associated suicidal ideation, which warrants urgent clarification.

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The Rewards of Extreme Weight Loss Pills

Despite the risks associated with extreme weight loss pills, there are some potential rewards for individuals who use them responsibly and under the guidance of a healthcare provider. One of the most significant benefits of these pills is the rapid results they can provide. For individuals who have struggled to lose weight through traditional methods, extreme weight loss pills can offer a quick and effective solution to jumpstart their weight loss journey.

Additionally, extreme weight loss pills can provide motivation and momentum for individuals to make healthier choices in other areas of their lives. Seeing rapid results from these pills can inspire individuals to continue making positive changes, such as adopting a healthier diet and incorporating regular exercise into their routine. This can lead to long-term weight loss success and improved overall health.

Lastly, extreme weight loss pills can be a valuable tool for individuals who have a significant amount of weight to lose and are at risk of complications from obesity. In these cases, the benefits of rapid weight loss may outweigh the risks associated with these pills, as losing weight quickly can improve overall health and reduce the risk of obesity-related diseases.

Conclusion

Before considering extreme weight loss pills as a solution to weight loss, it is essential to weigh the risks and rewards carefully. While these pills can offer rapid results and provide motivation for individuals to make positive lifestyle changes, they also come with significant risks that should not be taken lightly. It is crucial to consult with a healthcare provider before starting any regimen of extreme weight loss pills to ensure that they are safe and appropriate for your individual needs and health goals.

In conclusion, extreme weight loss pills can be a powerful tool for individuals looking to shed excess pounds quickly, but they should be used cautiously and under the guidance of a healthcare professional to minimize the potential risks and maximize the rewards of aggressive diets.

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Chris met up with Dr. Ken Berry at Low Carb Denver not long ago. They talked all things Daily Minerals. What are they? Why are they? Who are they for? Keto Chow Daily Minerals: https://tinyurl.com/bkfzdhx3 Watch the full Q&A session here: https://youtu.be/rF5sFkHaEY4?feature=shared

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Join us for the FIRST ever episode of our weekly webinar series, hosted by our expert Registered Dietitian (Laura Goldman)! In this interactive session, we dive into the essential role of protein when using GLP-1 medications like Ozempic and Zepbound for weight loss. Learn practical nutrition hacks, discover the best protein sources to support your journey! This is just the beginning of our exciting weekly series designed exclusively for our Premier Weight Loss members. Each week, we’ll tackle new topics and provide actionable insights to help you achieve your weight loss goals. Don’t miss out on this dynamic and engaging experience!

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Send us a message with this link, we would love to hear from you. Standard message rates may apply. (https://www.buzzsprout.com/twilio/text_messages/2346940/open_sms) This episode of Your Checkup examines a recent study investigating the effects of semaglutide, a medication used for weight loss, on individuals with both obesity and knee osteoarthritis. We will delve into how this trial was conducted, the key findings related to weight reduction and pain relief, and what these results might mean for patients experiencing these conditions. The study showed that semaglutide led to significant weight loss and pain reduction in participants. Join us as we explore the potential benefits and considerations of this new treatment approach Support the show (https://buymeacoffee.com/yourcheckup) Production and Content: Edward Delesky, MD & Nicole Aruffo, RN Artwork: Olivia PawlowskiLizzo New Weight Loss Journey Shorts