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🎙️EP282|善纖達,猛健樂,所有GLP-1受體促效劑:減重、控糖、護心腎?從藥物比較到臨床應用全解析 — 📌主題亮點: • GLP-1受體促效劑的作用機轉是什麼?為何能兼顧控糖與體重管理? • Tirzepatide、Semaglutide、Liraglutide 怎麼選?療效與副作用比較一次看懂 • 台灣健保給付限制、仿單外使用、心腎保護證據,全方位解析臨床現況 — 🔍內容解析: 本集重點: GLP-1受體促效劑(Glucagon-like peptide-1 receptor agonists, GLP-1 RAs)是目前糖尿病與肥胖症領域中最受矚目的藥物類別之一。這類藥物最初設計目的是控制第二型糖尿病血糖,但其延緩胃排空與降低食慾的機制,逐漸展現出優異的體重控制效果,成為減重治療的重要選項。 本集將全面比較目前臨床上常見的 GLP-1 RAs,包括 Semaglutide、Liraglutide、Dulaglutide、Exenatide、Tirzepatide 等,從作用機制、臨床療效、安全性,到心腎保護與健保給付現況,帶你掌握這波醫藥創新的核心。 — 🧩主題分段解析: — 🧬 GLP-1作用機轉:多重代謝效應的關鍵介質 GLP-1 是人體腸道於進食後釋放的一種腸泌素,具有多重生理功能: • 刺激胰島素分泌(在高血糖狀態下) • 抑制昇糖素分泌 • 延緩胃排空,增加飽足感 • 對中樞神經產生抑制食慾作用 GLP-1受體促效劑則是模擬這一生理訊號的藥物。由於天然 GLP-1 在體內迅速被 DPP-4 分解,因此這類藥物皆經修飾以延長半衰期,使其可每日或每週注射。 ⸻ 🩺 臨床療效比較:控糖與體重減輕雙重奏 根據大型隨機試驗與統合分析,GLP-1 RAs 在控制血糖(HbA1c)與體重管理上皆展現出顯著成效。 📌 各藥物臨床成效對比: 藥物名稱 HbA1c 降幅 體重減輕效果 使用頻率 核准適應症 Semaglutide -1.4 ~ -1.9% -6~15% 每週1次 第2型糖尿病、肥胖(國際核准) Tirzepatide -2.0 ~ -2.4% -10~20% 每週1次 第2型糖尿病(減重待核准) Liraglutide -1.0 ~ -1.5% -5~8% 每日1次 糖尿病、肥胖(Saxenda商品名) Dulaglutide -0.7 ~ -1.5% -2~5% 每週1次 糖尿病 Exenatide -0.8 ~ -1.0% -2~3% 每週或每日 糖尿病 其中 Tirzepatide 屬於 GIP/GLP-1 雙重受體促效劑,在 SURMOUNT 與 SURPASS 試驗中展現出前所未有的血糖控制與減重表現,有望改寫治療標準。 — 💖 心血管與腎臟保護:超越控糖的新方向 越來越多研究指出,GLP-1 RAs 除了降血糖與減重,也具有心腎保護效果,這點在糖尿病病人族群中特別重要。 📌 心血管研究亮點: • LEADER試驗(Liraglutide): 減少 MACE(重大心血管事件)13% • SUSTAIN-6(Semaglutide): 顯著降低心血管事件與腎功能惡化風險 • REWIND(Dulaglutide): 在高風險群中降低中風與心臟衰竭住院率 腎臟方面,GLP-1 RAs 可延緩 eGFR 下降速度、降低蛋白尿發生,與 SGLT2i 一同被納入 CKD 病患用藥建議中(KDIGO 2022)。 — ⚠️ 常見副作用與風險考量 GLP-1 類藥物最常見的不良反應是胃腸道不適: • 噁心、嘔吐、腹瀉(劑量上升時尤明顯) • 厭食、味覺改變 此外,也需注意以下安全議題: 1. 胰臟炎風險: 少見但需警惕,特別是胰臟病史者 2. 甲狀腺 C 細胞腫瘤: 動物實驗有顯示,故有甲狀腺腫瘤病史者應避免使用 3. 低血糖風險: 單用風險低,但與 SU 類或胰島素併用時需留意 4. 腎功能不全: 輕中度 CKD 可使用,但末期腎病需個別評估 目前各大指引皆建議以「緩慢劑量上升」的方式起始治療,以改善耐受性。 — 📋 台灣市場與健保現況:法規限制與臨床建議 雖然 GLP-1 RAs 在國際間已被廣泛應用於肥胖與代謝症候群治療,但在台灣市場仍受到幾項限制: 1. 健保給付範圍有限: 僅核准用於第二型糖尿病患者,且常須 HbA1c > 7.5% 且合併肥胖者 2. 體重管理為仿單外使用: 減重用途目前無正式健保核准 3. 高藥價問題: 自費族群常成經濟負擔障礙 4. 專科醫師使用限制: 多數藥品須由內分泌科或新陳代謝科開立 根據 NHIA 公告,目前 Semaglutide(Ozempic)與 Liraglutide(Victoza)皆列為給付藥品,但需符合嚴格條件。 — 🚶♀️ 臨床應用建議:如何選擇最適合的 GLP-1 受體促效劑? 臨床選擇應考慮以下因素: • 目標: 控糖為主或減重為主? • 用藥頻率接受度: 每日注射 vs 每週注射 • 腎功能狀況 • 副作用耐受性 • 病患偏好與經濟狀況 📌舉例: • 對減重有高度期待者:Tirzepatide > Semaglutide > Liraglutide • CKD早期患者:Semaglutide、Dulaglutide皆可考慮 • 容易噁心者:可考慮低劑量起始且選擇耐受性較佳者如 Dulaglutide • 自費負擔有限者:評估 Liraglutide 台灣仿單內使用是否適用 — 📣負責任的行動: GLP-1 受體促效劑不只是「減重神藥」,而是結合代謝改善、心腎保護與控糖成效的複合型療法。醫師在使用前應評估患者整體代謝風險、心血管病史與用藥習慣,避免將此藥物視為「萬靈丹」。 病患亦應接受完整衛教,了解可能副作用與正確使用方法,避免自行停藥或過度依賴。 — 📚熱門關鍵字: #GLP1受體促效劑 #Semaglutide #Ozempic #Tirzepatide #Mounjaro #Liraglutide #Saxenda #減重藥物 #糖尿病治療 #心血管保護 #腎臟保護 #胰島素促進劑 #胃排空延緩 #體重管理 #胃腸道副作用 #甲狀腺C細胞腫瘤 #台灣健保給付 #仿單外使用 #慢性腎病新療法 #糖尿病臨床指引 — 🎤主講人資訊: Dr.Happy Human Plumber|心血管知識推廣者 擅長將複雜代謝藥物與心腎內科整合知識,轉化為清晰易懂的內容,關注台灣臨床處方趨勢與全球新藥發展,致力於提升醫病雙方的治療選擇品質。 Powered by Firstory Hosting (https://firstory.me/zh)
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weight loss exercises at home#yoga #ytshorts #weightloss #athome #exercise #yoga #routines #diet #goals #daily #shorts #youtubeshorts Please Follow Me Desclaimer:- video is for educational purpose only. Copyright Disclaimer: - Under section 107 of the copyright Act 1976, allowance is mad for FAIR USE for purpose such a as criticism, comment, news reporting, teaching, scholarship and research. Fair use is a use permitted by copyright statues that might otherwise be infringing. Non- Profit, educational or personal use tips the balance in favor of FAIR US
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Statin Medication Side Effects | Side Effects of Atorvastatin, Rosuvastatin, Simvastatin Statins are medications used to reduce or lower cholesterol and work by inhibiting synthesis of cholesterol. Their use, however, has been demonstrated to cause some significant and serious side effects. In this lesson, we discuss the side effects of statins, including how they happen and why they happen. ------------------------------------------------------------------------------------------------------------ **MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for EDUCATIONAL PURPOSES ONLY, and information presented here is NOT TO BE USED as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition. EXCLAIMER: The content used in this lesson is used in accordance with Fair Use laws and is intended for educational purposes only. ------------------------------------------------------------------------------------------------------------ I hope you find this lesson helpful. If you do, please consider liking, subscribing and clicking the notification bell to help support the channel and stay up-to-date on future lessons. JJ *Subscribe for more free medical lessons* https://www.youtube.com/channel/UCFPvnkCZbHfBvV8ApBBE0vA?sub_confirmation=1 ------------------------------------------------------------------------------------------------------------ *Check Out Some of My Other Lessons* Medical Terminology - The Basics - Lesson 1: https://www.youtube.com/watch?v=04Wh2E9oNug Infectious Disease Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b Dermatology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwW3dgORRNmk_MZvnWpZx_lW Pharmacology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwWPWcV9lZTh-Qxv0gYakQXR Hematology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwW8Ajo1dmxdj4EYEKcbtGju Rheumatology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwWDvuhasXsuTFXJp05wwUle Endocrinology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwUuRSzhploohnaWVvbVZ7ZP Nephrology Playlist https://www.youtube.com/playlist?list=PLRjNoiRtdFwXRSwrFQK5WwWZLk1Las8v8 Fatty Acid Synthesis Pathway: https://www.youtube.com/watch?v=WuQS_LpNMzo Wnt/B Catenin Signaling Pathway: https://www.youtube.com/watch?v=NGVP4J9jpgs Upper vs. Lower Motor Neuron Lesions: https://www.youtube.com/watch?v=itNd74V53ng Lesson on the Purine Synthesis and Salvage Pathway: https://www.youtube.com/watch?v=e2KFVvI8Akk Gastrulation | Formation of Germ Layers: https://www.youtube.com/watch?v=d6Kkn0SECJ4 Introductory lesson on Autophagy (Macroautophagy): https://www.youtube.com/watch?v=UmSVKzHc5yA ------------------------------------------------------------------------------------------------------------- For books and more information on these topics https://www.amazon.com/shop/jjmedicine Support future lessons and lectures ➜ https://www.patreon.com/jjmedicine Start your own website with BlueHost ➜ https://www.bluehost.com/track/jjmedicine/ Check out the best tool to help grow your YouTube channel (it’s helped me!) https://www.tubebuddy.com/jjmedicine Follow me on Twitter! ➜ https://twitter.com/JJ_Medicine Come join me on Facebook! ➜ https://www.facebook.com/JJ-Medicine-100642648161192/ ---------------------------------------------------------------------------------------------------- I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :) Thanks for watching! If you found this video helpful, please like and subscribe! JJ ---------------------------------------------------------------------------------------------------- DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
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Haferflocken sind eine beliebte Wahl, wenn es darum geht, Gewicht zu verlieren. Sie sind reich an Ballaststoffen, Proteinen und Vitaminen, die alle dazu beitragen können, das Sättigungsgefühl zu erhöhen und den Stoffwechsel anzukurbeln. Viele Menschen schwören auf Haferflocken als Teil ihrer Diät, um Pfunde zu verlieren und gesünder zu leben. Aber sind Haferflocken wirklich gut zum Abnehmen? In diesem Artikel werfen wir einen Blick auf die Ernährungsfakten von Haferflocken und teilen einige leckere Rezepte, die Ihnen helfen können, Ihre Abnehmziele zu erreichen.
Ernährungsfakten von Haferflocken
Haferflocken sind eine hervorragende Quelle für Ballaststoffe, insbesondere lösliche Ballaststoffe, die dazu beitragen können, das Sättigungsgefühl zu erhöhen und den Blutzuckerspiegel stabil zu halten. Sie enthalten auch eine gute Menge an Proteinen, die beim Aufbau und Erhalt von Muskelmasse helfen können. Darüber hinaus sind Haferflocken reich an wichtigen Vitaminen und Mineralstoffen wie Eisen, Magnesium und B-Vitaminen.
Ein weiterer Vorteil von Haferflocken ist ihr niedriger glykämischer Index, der bedeutet, dass sie den Blutzuckerspiegel nicht so stark ansteigen lassen wie andere kohlenhydratreiche Lebensmittel. Dies kann dazu beitragen, Heißhungerattacken zu vermeiden und den Gewichtsverlust zu unterstützen. Außerdem enthalten Haferflocken Beta-Glucane, die die Darmgesundheit fördern und das Immunsystem stärken können.
Es ist jedoch wichtig zu beachten, dass Haferflocken auch Kalorien enthalten, daher ist es wichtig, die Portionsgröße im Auge zu behalten, wenn Sie versuchen, abzunehmen. Eine Portionsgröße von etwa 30 Gramm Haferflocken enthält ungefähr 117 Kalorien, daher ist es ratsam, diese in Ihre tägliche Kalorienzufuhr zu integrieren, anstatt sie in großen Mengen zu konsumieren.
Haferflocken-Rezepte zum Abnehmen
Haferflocken sind äußerst vielseitig und können auf verschiedene Weisen zubereitet werden, um Ihren Gewichtsverlust zu unterstützen. Hier sind einige leckere Rezepte, die Sie ausprobieren können:
1. Haferflocken-Brei mit frischem Obst und Nüssen: Kochen Sie Haferflocken in Wasser oder Milch und servieren Sie sie mit frischen Beeren, Bananen und gehackten Nüssen für eine nahrhafte Mahlzeit.
2. Haferflocken-Pancakes: Mixen Sie Haferflocken, Eier, Bananen und Zimt für einen gesunden Pancake-Teig und braten Sie sie in einer Pfanne für ein leckeres Frühstück oder Snack.
3. Haferflocken-Smoothie: Mixen Sie Haferflocken, Joghurt, frisches Obst und Leinsamen für einen ballaststoffreichen Smoothie, der Sie den ganzen Tag über sättigt. Ideal für unterwegs!
Tipps zur Verwendung von Haferflocken für den Gewichtsverlust
Wenn Sie Haferflocken in Ihre Ernährung aufnehmen möchten, um Gewicht zu verlieren, hier sind einige Tipps, die Ihnen helfen können, Ihre Abnehmziele zu erreichen:
1. Wählen Sie am besten Vollkorn-Haferflocken, da sie mehr Ballaststoffe und Nährstoffe enthalten im Vergleich zu verarbeiteten Haferflocken.
2. Experimentieren Sie mit verschiedenen Rezepten, um Haferflocken in Ihre Mahlzeiten zu integrieren, von Müslis über Smoothies bis zu Backwaren.
3. Achten Sie auf die Portionsgröße und geben Sie nicht zu viel Zucker oder Fett zu Ihren Haferflockenrezepten hinzu, um den Kaloriengehalt niedrig zu halten.
Haferflocken als Teil einer ausgewogenen Ernährung
Haferflocken können sicherlich ein gesunder Bestandteil einer ausgewogenen Ernährung sein, insbesondere wenn Sie versuchen, Gewicht zu verlieren. Sie sind reich an Ballaststoffen, Proteinen und Vitaminen, die alle zur Sättigung beitragen und den Stoffwechsel fördern können. Durch die Verwendung von Haferflocken in verschiedenen Rezepten können Sie auf einfache und schmackhafte Weise Ihre Gesundheitsziele erreichen. Denken Sie daran, dass eine ausgewogene Ernährung und regelmäßige Bewegung ebenfalls wichtige Komponenten eines erfolgreichen Gewichtsverlustprogramms sind.
FAQ zu Haferflocken und Gewichtsverlust
1. Kann man Haferflocken zum Abendessen essen, um Gewicht zu verlieren?
Ja, Haferflocken können eine gute Option für ein leichtes und sättigendes Abendessen sein, insbesondere wenn Sie sie mit proteinreichen Lebensmitteln wie Milch oder Joghurt kombinieren.
2. Wie viele Haferflocken sollte man pro Tag essen, um abzunehmen?
Es wird empfohlen, eine Portion Haferflocken pro Tag zu konsumieren, die etwa 30 Gramm entspricht, um von den gesundheitlichen Vorteilen zu profitieren, ohne zu viele Kalorien zu sich zu nehmen.
3. Sind Haferflocken gut für den Gewichtsverlust, wenn man an einer Glutenunverträglichkeit leidet?
Ja, Haferflocken sind von Natur aus glutenfrei, aber es ist wichtig sicherzustellen, dass sie nicht mit glutenhaltigen Getreidearten verunreinigt sind, wenn Sie an Zöliakie oder einer Glutenunverträglichkeit leiden.
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